[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100539652":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":40,"responsibleParty":256,"collaborators":24,"id":258,"slug":259,"hasResults":260,"nctId":261,"briefTitle":262,"officialTitle":263,"acronym":264,"eligibilityCriteria":265,"healthyVolunteers":260,"sex":266,"minAge":267,"maxAge":268,"enrollmentInfo":269,"targetDuration":24,"studyType":272,"phases":273,"briefSummary":275,"conditions":276,"keywords":278,"overallStatus":120,"whyStopped":24,"lastUpdateSubmitDate":284,"lastUpdatePostDateStruct":285,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":293},{"fullName":5,"class":6},"Hospices Civils de Lyon","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Remote ischemic conditioning","EXPERIMENTAL","A brachial cuff is positioned around one arm of the patient. Remote ischemic conditioning consists of alternating inflations and deflations of the brachial cuff. Four cycles of ischemic conditioning (5-min brachial cuff inflation at 200 millimetres of mercury (mmHg) followed by 5-min cuff deflation) are started as soon as possible after inclusion. The intervention is repeated 12 and 24 hours after inclusion.",[13],"Device: Remote ischemic conditioning",{"label":15,"type":6,"description":16,"interventionNames":17},"Control group","A brachial cuff is positioned around one arm of the patient. Neither inflation nor deflation is performed.",[18],"Device: No remote ischemic conditioning",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"DEVICE","A brachial cuff is positioned around one arm of the patient. Remote ischemic conditioning consists of four cycles of a 5-min brachial cuff inflation at 200 mmHg followed by a 5-min of cuff deflation, and is started as soon as possible after randomization. The intervention is repeated 12 and 24 hours after inclusion.",[9],null,{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"No remote ischemic conditioning","A brachial cuff is positioned around the arm of the patient and no inflation or deflation is performed.",[15],[30,36],{"name":31,"role":32,"phone":33,"phoneExt":34,"email":35},"Marie-Line Harlay","CONTACT","04 72 11 28 62","+33","marie-line.harlay@chu-lyon.fr",{"name":37,"role":32,"phone":38,"phoneExt":34,"email":39},"Naoual EL JONHY","0472356912","naoual.el-jonhy@chu-lyon.fr",[41,61,76,88,103,118,139,151,166,181,196,211,226,241],{"facility":42,"status":43,"city":44,"state":24,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Hôpital Louis Pradel","NOT_YET_RECRUITING","Bron","69500","France","FR",{"type":49,"coordinates":50},"Point",[51,52],4.91303,45.73865,{"lat":52,"lon":51},[55,59],{"name":56,"role":32,"phone":57,"phoneExt":34,"email":58},"Thomas BOCHATON","04 72 35 75 41","thomas.bochaton@chu-lyon.fr",{"name":56,"role":60,"phone":24,"phoneExt":24,"email":24},"PRINCIPAL_INVESTIGATOR",{"facility":62,"status":43,"city":63,"state":24,"zip":64,"country":46,"countryCode":47,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"Hôpital Gabriel Montpied, CHU de Clermont Ferrand","Clermont-Ferrand","63000",{"type":49,"coordinates":66},[67,68],3.08682,45.77969,{"lat":68,"lon":67},[71,75],{"name":72,"role":32,"phone":73,"phoneExt":34,"email":74},"Maxime DUMESNIL","04 73 75 07 50","mdumesnil@chu-clermontferrand.fr",{"name":72,"role":60,"phone":24,"phoneExt":24,"email":24},{"facility":77,"status":43,"city":63,"state":24,"zip":78,"country":46,"countryCode":47,"cosmosGeoPoint":79,"geoPoint":81,"contacts":82},"Centre Jean Perrin, Clermont-Ferrand","69300",{"type":49,"coordinates":80},[67,68],{"lat":68,"lon":67},[83,87],{"name":84,"role":32,"phone":85,"phoneExt":34,"email":86},"Alexandre LAUTRETTE","04 73 27 80 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79","cschwebel@chu-grenoble.fr",{"name":114,"role":60,"phone":24,"phoneExt":24,"email":24},{"facility":119,"status":120,"city":121,"state":24,"zip":122,"country":46,"countryCode":47,"cosmosGeoPoint":123,"geoPoint":127,"contacts":128},"Hôpital Edouard Herriot","RECRUITING","Lyon","69003",{"type":49,"coordinates":124},[125,126],4.84789,45.74906,{"lat":126,"lon":125},[129,131,134,135,137],{"name":130,"role":32,"phone":33,"phoneExt":34,"email":35},"Marie-Line HARLAY",{"name":132,"role":32,"phone":33,"phoneExt":34,"email":133},"Laurent ARGAUD","laurent.argaud@chu-lyon.fr",{"name":130,"role":60,"phone":24,"phoneExt":24,"email":24},{"name":132,"role":136,"phone":24,"phoneExt":24,"email":24},"SUB_INVESTIGATOR",{"name":138,"role":136,"phone":24,"phoneExt":24,"email":24},"Martin COUR",{"facility":140,"status":120,"city":121,"state":24,"zip":141,"country":46,"countryCode":47,"cosmosGeoPoint":142,"geoPoint":144,"contacts":145},"Hôpital Saint-Joseph Saint-Luc","69007",{"type":49,"coordinates":143},[125,126],{"lat":126,"lon":125},[146,150],{"name":147,"role":32,"phone":148,"phoneExt":34,"email":149},"Emmanuel VIVIER","04 78 61 82 09","evivier@ch-stjosephstluc-lyon.fr",{"name":147,"role":60,"phone":24,"phoneExt":24,"email":24},{"facility":152,"status":120,"city":153,"state":24,"zip":154,"country":46,"countryCode":47,"cosmosGeoPoint":155,"geoPoint":159,"contacts":160},"Hôpital de la Timone, CHU de Marseille","Marseille","13385",{"type":49,"coordinates":156},[157,158],5.38107,43.29695,{"lat":158,"lon":157},[161,165],{"name":162,"role":32,"phone":163,"phoneExt":34,"email":164},"Marc GAINNIER","04 91 38 85 50","marc.gainnier@ap-hm.fr",{"name":162,"role":60,"phone":24,"phoneExt":24,"email":24},{"facility":167,"status":120,"city":168,"state":24,"zip":169,"country":46,"countryCode":47,"cosmosGeoPoint":170,"geoPoint":174,"contacts":175},"Hôpital lapeyronie, CHU de Montpellier","Montpellier","34295",{"type":49,"coordinates":171},[172,173],3.87635,43.61093,{"lat":173,"lon":172},[176,180],{"name":177,"role":32,"phone":178,"phoneExt":34,"email":179},"Kada KLOUCHE","04 67 33 77 36","k-klouche@chu-montpellier.fr",{"name":177,"role":60,"phone":24,"phoneExt":24,"email":24},{"facility":182,"status":43,"city":183,"state":24,"zip":184,"country":46,"countryCode":47,"cosmosGeoPoint":185,"geoPoint":189,"contacts":190},"Hôpital Universitaire Carémeau","Nîmes","30029",{"type":49,"coordinates":186},[187,188],4.35788,43.83665,{"lat":188,"lon":187},[191,195],{"name":192,"role":32,"phone":193,"phoneExt":34,"email":194},"Claire ROGER","04 66 68 33 31","claire.roger@chu-nimes.fr",{"name":192,"role":60,"phone":24,"phoneExt":24,"email":24},{"facility":197,"status":43,"city":198,"state":24,"zip":199,"country":46,"countryCode":47,"cosmosGeoPoint":200,"geoPoint":204,"contacts":205},"Hôpital Lariboisière, APHP, Réanimation Médicale et Toxicologique","Paris","75010",{"type":49,"coordinates":201},[202,203],2.3488,48.85341,{"lat":203,"lon":202},[206,210],{"name":207,"role":32,"phone":208,"phoneExt":34,"email":209},"Sebastian VOICU","01 49 95 84 42","sebastian.voicu@aphp.fr",{"name":207,"role":60,"phone":24,"phoneExt":24,"email":24},{"facility":212,"status":120,"city":213,"state":24,"zip":214,"country":46,"countryCode":47,"cosmosGeoPoint":215,"geoPoint":219,"contacts":220},"Hôpital Lyon-Sud","Pierre-Bénite","69310",{"type":49,"coordinates":216},[217,218],4.82424,45.70359,{"lat":218,"lon":217},[221,225],{"name":222,"role":32,"phone":223,"phoneExt":34,"email":224},"Auguste DARGENT","04 78 86 21 18","auguste.dargent@chu-lyon.fr",{"name":222,"role":60,"phone":24,"phoneExt":24,"email":24},{"facility":227,"status":120,"city":228,"state":24,"zip":229,"country":46,"countryCode":47,"cosmosGeoPoint":230,"geoPoint":234,"contacts":235},"Hôpital Nord, CHU de St Etienne","Saint-Priest-en-Jarez","42270",{"type":49,"coordinates":231},[232,233],4.37678,45.4739,{"lat":233,"lon":232},[236,240],{"name":237,"role":32,"phone":238,"phoneExt":34,"email":239},"Guillaume THIERY","04 77 12 78 62","guillaume.thiery@chu-st-etienne.fr",{"name":237,"role":60,"phone":24,"phoneExt":24,"email":24},{"facility":242,"status":120,"city":243,"state":24,"zip":244,"country":46,"countryCode":47,"cosmosGeoPoint":245,"geoPoint":249,"contacts":250},"Hôpital Nord-Ouest","Villefranche-sur-Saône","69655",{"type":49,"coordinates":246},[247,248],4.71961,45.98967,{"lat":248,"lon":247},[251,255],{"name":252,"role":32,"phone":253,"phoneExt":34,"email":254},"Julien ILLINGER","04 74 09 29 31","jillinger@hno.fr",{"name":252,"role":60,"phone":24,"phoneExt":24,"email":24},{"type":257,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100539652","remote-conditioning-in-out-of-hospital-cardiac-arrest-100539652",false,"NCT06306625","REmote COnditioning in Out-of-Hospital Cardiac Arrest","REmote Ischemic COnditioning in Out-of-Hospital Cardiac Arrest: The RECO-OHCA Study","RECO-OHCA","Inclusion Criteria:\n\n* Age between 18 and 80 years old\n* Out-of-hospital cardiac arrest, whatever the initial cardiac rhythm (shockable or non-shockable) or the duration of no-flow and low-flow,\n* Presence of a witness who may or may not have started cardiopulmonary resuscitation, or patient seen alive in the 30 minutes prior to the cardiac arrest,\n* Hospitalisation in critical care (intensive care unit or cardiac intensive care unit) for less than 3 hours,\n* Informed consent obtained from a close relative (exceptionally from the patient himself if his condition permits) or, failing this, use of the emergency procedure by the investigator.\n\nExclusion Criteria:\n\n* Traumatic cardiac arrest\n* Patient on extracorporeal circulatory assistance\n* Cardiac arrest for which continuation of resuscitation does not appear justified (unavoidable death, terminal stage of an irreversible disease, etc.)\n* Contraindication of the use of brachial cuff on both arms (arteriovenous fistula, lymphoedema or severe peripheral vascular pathology, unstable humeral fracture, continuous infusion into an upper limb vein of an essential drug such as a catecholamine, radial arterial catheter for continuous invasive measurement of blood pressure)\n* Pregnant, parturient, or breast-feeding women\n* Patients deprived of their liberty by a judicial or administrative decision,\n* Patients under legal protection (guardianship, curatorship),\n* Patient not affiliated to a social security scheme or beneficiary of a similar scheme,\n* Previous inclusion in the study,\n* Subject participating in other interventional research that may interfere with the present study according to the investigator's judgement or that includes an exclusion period still in progress at inclusion","ALL","18 Years","80 Years",{"count":270,"type":271},220,"ESTIMATED","INTERVENTIONAL",[274],"NA","Out-of-Hospital Cardiac Arrest remains a major public health problem, resulting in high mortality largely related to multiple organ failure and poor neurological outcomes due to brain anoxia. The pathophysiology of organ dysfunction after resuscitated out-of-hospital cardiac arrest involves ischemia-reperfusion processes. Remote ischemic conditioning is a therapeutic strategy used to protect organs against the detrimental effects of ischemia-reperfusion injury.\n\nThe objective of the present trial is to determine whether remote ischemic conditioning performed early after out-of-hospital cardiac arrest can decrease mortality, or multiple organ failure and\u002For severe neurological failure.",[277],"Out-Of-Hospital Cardiac Arrest",[279,280,281,282,283],"Out-of-hospital cardiac arrest","remote conditioning","ischemic conditioning","ischemia-reperfusion","intensive care unit","2025-02-11",{"date":286,"type":287},"2025-02-12","ACTUAL",{"date":289,"type":287},"2024-06-21",{"date":291,"type":271},"2026-10-05",{"name":5,"class":6},14]