[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606771":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":35,"centralContacts":39,"locations":48,"responsibleParty":68,"collaborators":71,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":30,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":96,"overallStatus":51,"whyStopped":30,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"University of Nottingham","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"High dose RIC","EXPERIMENTAL","Daily sessions of RIC for 6 weeks. Each session will consist of 4 x 5 minute cuff inflation to 20mmHg above systolic blood pressure, interspersed with 5 minute periods of cuff deflation",[13],"Device: Remote Ischaemic Conditioning",{"label":15,"type":10,"description":16,"interventionNames":17},"Low dose RIC","3x weekly sessions of RIC for 6 weeks. Each session will consist of 4 x 5 minute cuff inflation to 20mmHg above systolic blood pressure, interspersed with 5 minute periods of cuff deflation",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Sham RIC","PLACEBO_COMPARATOR","3x weekly sessions of Sham RIC for 6 weeks. Each session will consist of 4 x 5 minute cuff inflation to 20mmHg only, interspersed with 5 minute periods of cuff deflation",[23],"Device: Sham Remote Ischaemic Conditioning",[25,31],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DEVICE","Remote Ischaemic Conditioning","Cuff inflation to 20mmHg abocve systolic blood pressure for cycles of 5 minutes. Each session will consist of 4 cycles of 5 minte inflation followed by 5 minute deflation. Total session time 40 minutes",[9,15],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Sham Remote Ischaemic Conditioning","Cuff inlfation to 20mmHg only for cycles of 5 minutes. Each session will consist of 4 cycles of 5 minute inflation followed by 5 minutes of deflation. Total session time of 40 minutes",[19],[36],{"name":37,"affiliation":5,"role":38},"Tim England, MBChB PhD","PRINCIPAL_INVESTIGATOR",[40,45],{"name":41,"role":42,"phone":43,"phoneExt":30,"email":44},"Harry Keevil, MB BChir","CONTACT","+441332 724676","harry.keevil@nottingham.ac.uk",{"name":37,"role":42,"phone":46,"phoneExt":30,"email":47},"+441332724676","Timothy.England@nottingham.ac.uk",[49],{"facility":50,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"School of Medicine, University of Nottingham, Royal Derby Hospital Centre","RECRUITING","Derby","Derbyshire","DE22 3DT","United Kingdom","UK",{"type":58,"coordinates":59},"Point",[60,61],-1.47663,52.92277,{"lat":61,"lon":60},[64,65],{"name":41,"role":42,"phone":43,"phoneExt":30,"email":44},{"name":66,"role":42,"phone":43,"phoneExt":30,"email":67},"Bethan E Phillips, BSc PhD","beth.phillips@nottingham.ac.uk",{"type":38,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Timothy England","Professor of Stroke Medicine",[72],{"name":73,"class":6},"University of Leicester","100606771","remote-ischaemic-conditioning-in-the-older-person-and-effects-on-dynamic-cerebral-autoregulation-100606771",false,"NCT07179887","Remote Ischaemic Conditioning in the Older Person and Effects on Dynamic Cerebral Autoregulation","RICE-DCA","Inclusion Criteria:\n\n* Participant is willing and able to give informed consent for participation in the study\n* Participant aged 65 - 85\n* Participant is able to perform RIC independently at home\n\nExclusion Criteria:\n\n* Active cardiovascular or cerebrovascular disease (acute event within the last 12 months)\n* Atrial fibrillation or other significant arrhythmias\n* Peripheral Vascular Disease\n* Haemostatic disorders\n* Soft tissue injury or fracture to the upper limb\n* Pregnant or breast feeding\n* History or current psychiatric illness\n* History or current neurological condition (e.g. epilepsy)\n* Inability to identify temporal window for transcranial doppler ultrasound at screening visit\n* Any condition or presentation under current investigation that is deemed by the study clinician to exclude the participant from the study.\n* Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance",true,"ALL","65 Years","85 Years",{"count":86,"type":87},45,"ESTIMATED","INTERVENTIONAL",[90],"NA","Remote Ischaemic Conditioning (RIC) is the process of inducing short periods of ischaemia in a limb with the aim of improving vascular health systemically. Recent findings have demonsatrated efficacy in a variety of clinical settings. However, the ideal protocol of RIC \\[dose\\] is unknown. Dynamic Cerebral Autoregulation (dCA) has been shown to increase in response to RIC.\n\nThe goal of this trial is to study whether an increase in RIC protocol intensity results in a larger effect on biomarkers of vascular health such as dCA.\n\nParticipants shall:\n\nReceive RIC daily, RIC thrice weekly or sham RIC thrice weekly for 6 weeks Visit the School of Medicine at baseline and at 6 weeks for measurement of biomarkers of vascular health including blood pressure, indices od dCA and blood plasma samples",[93,94,95],"Cerebral Autoregulation","Blood Pressure","Dynamic Cerebral Autoregulation",[27,95,97,98],"Vascular Health","Randomised Controlled Trial","2025-09-15",{"date":101,"type":102},"2025-09-18","ACTUAL",{"date":104,"type":102},"2025-08-27",{"date":106,"type":87},"2027-09-30",{"name":5,"class":6},1]