[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100518591":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":42,"locations":48,"responsibleParty":71,"collaborators":26,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":76,"sex":82,"minAge":83,"maxAge":26,"enrollmentInfo":84,"targetDuration":26,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":51,"whyStopped":26,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Aarhus University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Remote Ischemic Conditioning","EXPERIMENTAL","After randomization a large thigh blood pressure cuff will be placed on the lower limb. The cuff will be inflated to a pressure 30 mm Hg greater than the systolic arterial blood pressure measured by the patient's arterial line or upper limb blood pressure cuff. The adequate level of inflation will be confirmed by the absence of pulse in the ipsilateral pedal artery detected by palpation. If the pulse signal is still present, the cuff will be inflated further until it disappears. The cuff will remain inflated for 5 minutes. Then the cuff will be deflated and the limb allowed to re-perfuse for 5 minutes. The procedure will be repeated five times followed by reperfusion. The first session will be performed 24-72 hours after the initial hemorrhage, within the first 24 hours after treatment of aneurysm, and repeated every 24 hours, between 8-10 am, until post hemorrhagic day 14.",[13],"Device: Remote Ischemic Conditioning with Automatic Tourniquet Device",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham-RIC","SHAM_COMPARATOR","After randomization a large leg blood pressure cuff will be placed on the lower limb.\n\nThis cuff will be inflated to 50 mm Hg only. The device will the be operated by trained staff. The cuff will remain inflated for 5 minutes, then the cuff will be deflated for 5 minutes. The procedure will be repeated for five cycles. The first session will be performed 48-72 hours after the initial hemorrhage, at least 24 hours after treatment of aneurysm and repeated every 24 hours, between 8-10 am, until post hemorrhagic day 14.",[19],"Device: Sham Remote Ischemic Conditioning with Automatic Tourniquet Device",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Remote Ischemic Conditioning with Automatic Tourniquet Device","5 Cycles of Remote Ischemic Conditioning performed on the leg. One cycle consists of 5 minutes of arterial occlusion followed by 5 minutes of reperfusion. The above is repeated daily for 14 days or until patient is discharged.\n\nPatients are randomized to either active Remote Ischemic Conditioning or Sham-treatment.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Sham Remote Ischemic Conditioning with Automatic Tourniquet Device","5 Cycles of sham-treatment performed on the leg. One cycle consists of 5 minutes of sham-treatment followed by 5 minutes of pause. The above is repeated daily for 14 days or until patient is discharged.\n\nPatients are randomized to either active Remote Ischemic Conditioning or Sham-treatment.",[15],[32],"Sham",[34,38],{"name":35,"affiliation":36,"role":37},"Grethe Andersen, Prof., MD","Department of Neurology, Aarhus University Hospital","PRINCIPAL_INVESTIGATOR",{"name":39,"affiliation":40,"role":41},"Arzu Bilgin-Freiert, MD, PhD","Department of Neurosurgery","STUDY_DIRECTOR",[43],{"name":44,"role":45,"phone":46,"phoneExt":26,"email":47},"Kim M Ørskov, MD","CONTACT","+4542791933","kimoer@rm.dk",[49],{"facility":50,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Department of Neurosurgery, Aarhus University Hospital","RECRUITING","Aarhus N","Danmark","DK-8200","Denmark","DK",{"type":58,"coordinates":59},"Point",[60,61],10.17317,56.20367,{"lat":61,"lon":60},[64,66,69],{"name":65,"role":45,"phone":26,"phoneExt":26,"email":26},"Jens Christian H Sørensen, Prof., MD",{"name":39,"role":45,"phone":67,"phoneExt":26,"email":68},"+4529474197","arzbil@rm.dk",{"name":44,"role":70,"phone":26,"phoneExt":26,"email":26},"SUB_INVESTIGATOR",{"type":37,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Grethe Andersen","Professor, Consultant Neurologist, MD","100518591","remote-ischemic-conditioning-in-aneurysmal-sah-100518591",false,"NCT06032533","Remote Ischemic Conditioning in Aneurysmal SAH","The Effect of Remote Ischemic Conditioning on Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage: A Prospective, Randomized, Patient-assessor Blinded, Sham-controlled Pilot Study Investigating Effect on Clinical Outcome.","RESCUE-SAH","Inclusion Criteria:\n\n* Aneurysmal subarachnoid hemorrhage confirmed by computed tomography (CT) with aneurysm origin confirmed by computed tomography angiography (CTA) or digital subtraction angiography (DSA)\n* Aneurysmal subarachnoid hemorrhage symptom-onset ≤ 3 days\n* Aneurysm protected by clipping or coiling\n* Independent in daily living before symptom onset (mRS ≤ 2)\n\nExclusion Criteria:\n\n* Subarachnoid hemorrhage caused by a lesion other than cerebral aneurysm\n* Symptomatic vasospasm at the time of enrollment\n* Previous cerebral lesion e.g. symptomatic cerebral infarction (\\>2cm), multiple sclerosis, symptomatic intracerebral hemorrhage, tumour, prior neurosurgery (excluding prior clipping or coiling of cold aneurysms without complications).\n* History of severe peripheral vascular disease or signs of severe peripheral vascular disease on physical examination\n* History of deep vein thrombosis or signs of deep vein thrombosis on physical examination\n* Kidney involvement or prior kidney disease with an estimated glomerular filtration rate (eGFR) below safe levels for contrast infusion in relation to CT-perfusion.\n* Pregnancy (Women of child-bearing age will have serum-Humane Choriogonadotropine taken prior to final inclusion. If pregnancy cannot be ruled out,the patient can't be included. Women with a safe birth control method will be encouraged to use this method during the entire period of active treatment.)\n* Concomitant other acute life-threatening medical or surgical condition","ALL","18 Years",{"count":85,"type":86},100,"ESTIMATED","INTERVENTIONAL",[89],"NA","The goal of this clinical trial is to examine the effect of limb occlusion therapy (remote ischemic conditioning, RIC) in subjects with aneurysmal subarachnoid hemorrhage.\n\nThe main question it aims to answer is whether RIC can improve long-term recovery in participants with aneurysmal subarachnoid hemorrhage.\n\nResearchers will compare levels of functional independence in participants in the RIC-group to participants in the sham-group.",[92,93],"Subarachnoid Hemorrhage, Aneurysmal","Delayed Cerebral Ischemia",[9,95,96,93],"Subarachnoid Hemorrhage","Aneurysm","2025-09-30",{"date":99,"type":100},"2025-10-03","ACTUAL",{"date":102,"type":100},"2023-09-09",{"date":104,"type":86},"2027-11-30",{"name":5,"class":6},1]