[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625247":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":38,"responsibleParty":55,"collaborators":25,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":25,"enrollmentInfo":69,"targetDuration":25,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":25,"overallStatus":41,"whyStopped":25,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"University of Hamburg-Eppendorf","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"RIPC group","EXPERIMENTAL","In patients assigned to the RIPC group, we will perform RIPC on the day before surgery. If surgery is postponed, RIPC will be repeated on the day before the rescheduled surgery. RIPC will be performed with 3 cycles of upper-arm ischemia for 5 minutes followed by reperfusion for 5 minutes, using a blood pressure cuff inflated to 200 mmHg or to 50 mmHg above the systolic arterial pressure, whichever is higher.",[13],"Other: Remote ischemic preconditioning",{"label":15,"type":16,"description":17,"interventionNames":18},"No-RIPC group","ACTIVE_COMPARATOR","Patients assigned to the No-RIPC group will receive routine care and RIPC will not be performed. No sham procedure will be applied, given the objective nature of the primary outcome.",[19],"Other: Routine care",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Remote ischemic preconditioning","In patients assigned to the RIPC group, we will perform RIPC on the day before surgery.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Routine care","Patients assigned to the No-RIPC group will receive routine care and RIPC will not be performed.",[15],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Alina Bergholz","CONTACT","004940 7410 0","a.bergholz@uke.de",{"name":37,"role":33,"phone":25,"phoneExt":25,"email":25},"Bernd Saugel",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"University Medical Center Hamburg-Eppendorf","RECRUITING","Hamburg","Free and Hanseatic City of Hamburg","20246","Germany","DE",{"type":48,"coordinates":49},"Point",[50,51],9.99302,53.55073,{"lat":51,"lon":50},[54],{"name":32,"role":33,"phone":25,"phoneExt":25,"email":35},{"type":56,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Dr. Alina Bergholz","Principal Investigator","100625247","remote-ischemic-preconditioning-and-postoperative-neuronal-injury-100625247",false,"NCT07420153","Remote Ischemic Preconditioning and Postoperative Neuronal Injury","Remote Ischemic Preconditioning and Postoperative Neuronal Injury in Non-Cardiac Surgery Patients: A Randomized Trial","SHIELD","Inclusion criteria:\n\n* patients (≥50 years) scheduled for elective non-cardiac surgery with general anesthesia\n* patients at risk for postoperative delirium, defined as the presence of ≥2 of the following established risk factors: age ≥65 years, American Society of Anesthesiologists physical status classification of ≥III, Charlson Comorbidity, planned surgical duration \\>180 minutes, polypharmacy (regular intake of more than five medications), symptoms of depression (Patient Health Questionnaire-9 ≥10 points)\n\nExclusion criteria:\n\n* patients in whom RIPC cannot be safely applied due to relevant peripheral arterial disease (defined as Fontaine stage ≥II), lymphedema, recent upper-arm surgery, trauma, or skin lesions at the arm\n* patients with acute coronary syndrome (within the past month)\n* patients with surgery in the previous month\n* patients with intracranial surgery\n* patients with pre-existing delirium\n* patients with severe cognitive impairment preventing reliable delirium assessment\n* patients with current treatment with sulfonamides due to potential interference with ischemic preconditioning mechanisms\n* patients with previous participation in the SHIELD trial","ALL","50 Years",{"count":70,"type":71},216,"ESTIMATED","INTERVENTIONAL",[74],"NA","The SHIELD trial is a single-center, randomized, controlled, parallel-group, single-blinded clinical trial investigating whether performing RIPC one day before surgery-compared to not performing RIPC-reduces postoperative neuronal injury, as reflected by the maximum serum NfL concentration within the first 2 postoperative days, in non-cardiac surgery patients at risk for postoperative delirium.",[77],"Postoperative Neuronal Injury","2026-03-02",{"date":80,"type":81},"2026-03-04","ACTUAL",{"date":78,"type":81},{"date":84,"type":71},"2027-09",{"name":5,"class":6},1]