[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622460":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":26,"locations":36,"responsibleParty":80,"collaborators":84,"id":87,"slug":88,"hasResults":89,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":25,"eligibilityCriteria":93,"healthyVolunteers":89,"sex":94,"minAge":95,"maxAge":25,"enrollmentInfo":96,"targetDuration":25,"studyType":99,"phases":100,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":39,"whyStopped":25,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":119},{"fullName":5,"class":6},"Fujian Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"RIPC Intervention Group","EXPERIMENTAL","Participants randomized to this group will receive remote ischemic preconditioning (RIPC). After induction of general anesthesia, RIPC will be applied to the upper arm and thigh on the non-arterial cannulation side. The procedure consists of four alternating ischemia-reperfusion cycles, each cycle comprising 5 minutes of cuff inflation (at 200 mmHg, or systolic blood pressure +15 mmHg if systolic blood pressure exceeds 185 mmHg), followed by 5 minutes of cuff deflation for reperfusion. The inflation process alternates, starting with the upper arm. The thigh cuff inflation will begin only after the first upper arm inflation cycle is completed, and this process will repeat in alternating cycles.",[13],"Procedure: Remote ischemic preconditioning (RIPC)",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","SHAM_COMPARATOR","Participants randomized to this group will receive a sham RIPC procedure. The same cuff placement and timing as the experimental group are used, but the cuff is inflated to only 20 mmHg for 5 minutes followed by 5 minutes of deflation, simulating the RIPC procedure without inducing ischemia.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Remote ischemic preconditioning (RIPC)","This intervention is a non-invasive organ protection procedure. After induction of general anesthesia, 4 cycles of remote ischemic preconditioning (RIPC) are applied to the upper arm and thigh on the non-arterial cannulation side. Each cycle consists of 5 minutes of cuff inflation (at 200 mmHg, or systolic blood pressure +15 mmHg if systolic blood pressure exceeds 185 mmHg) to induce ischemia, followed by 5 minutes of cuff deflation for reperfusion. To ensure safety, the cuff inflation cycles alternate between the upper arm and thigh. The procedure aims to activate endogenous protective mechanisms, enhancing the tolerance of vital organs to subsequent ischemic injury during surgery.",[15,9],null,[27,32],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},"Liang-wan Chen, M.D Ph.D","CONTACT","+8613358255333","chenliangwan@fjmu.edu.cn",{"name":33,"role":29,"phone":34,"phoneExt":25,"email":35},"Xin-fan Lin, M.D","+8617850019550","lxf1885@163.com",[37,54,67],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Fujian Medical University Union Hospital","RECRUITING","Fuzhou","Fujian","350001","China","CN",{"type":46,"coordinates":47},"Point",[48,49],119.30611,26.06139,{"lat":49,"lon":48},[52],{"name":53,"role":29,"phone":30,"phoneExt":25,"email":31},"Liang-wan Chen",{"facility":55,"status":56,"city":57,"state":41,"zip":25,"country":43,"countryCode":44,"cosmosGeoPoint":58,"geoPoint":62,"contacts":63},"Xiamen Cardiovascular Hospital, Xiamen University","NOT_YET_RECRUITING","Xiamen",{"type":46,"coordinates":59},[60,61],118.08187,24.47979,{"lat":61,"lon":60},[64],{"name":65,"role":29,"phone":25,"phoneExt":25,"email":66},"Zhi Lin","proflinz@xmu.edu.cn",{"facility":68,"status":56,"city":69,"state":70,"zip":25,"country":43,"countryCode":44,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"The First Affiliated Hospital of Dalian Medical University","Dalian","Liaoning",{"type":46,"coordinates":72},[73,74],121.60222,38.91222,{"lat":74,"lon":73},[77],{"name":78,"role":29,"phone":25,"phoneExt":25,"email":79},"Xiao-ming Bian","bxiaoming@dmu.edu.cn",{"type":81,"investigatorFullName":82,"investigatorTitle":83,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Liang-Wan Chen MD","Chief",[85,86],{"name":68,"class":6},{"name":55,"class":6},"100622460","remote-ischemic-preconditioning-for-aute-type-a-aortic-dissection-surgery-100622460",false,"NCT07383909","Remote Ischemic Preconditioning for Aute Type A Aortic Dissection Surgery","Evaluation of the Organ-Protective Effects of Remote Ischemic Preconditioning in Patients Undergoing Surgery for Acute Type A Aortic Dissection: A Multicenter, Prospective, Double-Blind, Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age ≥18 years, with no restriction on sex;\n2. Diagnosis of acute Type A aortic dissection requiring emergency surgery (symptom onset \\\u003C14 days);\n3. Ability to understand the study objectives, voluntary provision of written informed consent by the patient or a legally authorized representative, and willingness to comply with follow-up.\n\nExclusion Criteria:\n\n1. Traumatic or iatrogenic aortic dissection;\n2. Previous open cardiac or thoracic aortic surgery;\n3. Severe preoperative dysfunction of vital organs, such as persistent deep coma, abdominal compartment syndrome, or circulatory failure;\n4. Severe comorbidities, including myocardial infarction within the past 7 days, stroke within the past 2 months; end-stage renal disease (eGFR \\\u003C30 ml\u002Fmin\u002F1.73 m²); end-stage liver disease (total bilirubin \\>342 μmol\u002FL or INR \\>2.0);\n5. Evidence of ischemia in the limb planned for intervention, such as decreased skin temperature, pain, pallor, with or without sensory disturbance, paralysis, or diminished\u002Fabsent pulses; or severe deformity or prior arteriovenous surgery at the intervention site;\n6. Peripheral arterial disease involving the limbs, Raynaud phenomenon, active phlebitis, or a history of deep vein thrombosis of the lower extremities;\n7. Current use of sulfonylurea oral hypoglycemic agents or nicorandil;\n8. Life expectancy \\\u003C1 year (e.g., advanced malignancy);\n9. Participation in another clinical trial without having reached its primary endpoint;\n10. Pregnancy or lactation; immunodeficiency (e.g., HIV positivity, history of organ transplantation); known bleeding disorders, coagulation abnormalities, or sickle cell anemia; active or uncontrolled infection;\n11. Other severe physical or psychiatric disorders, or laboratory abnormalities, which in the investigator's judgment may increase risk or interfere with study outcomes, rendering the patient unsuitable for enrollment.","ALL","18 Years",{"count":97,"type":98},1296,"ESTIMATED","INTERVENTIONAL",[101],"NA","The goal of this clinical trial is to learn if a technique called remote ischemic preconditioning (RIPC) helps protect organs during emergency surgery for acute type A aortic dissection (ATAAD). The main questions it aims to answer are:\n\nDoes RIPC reduce the risk of major complications after surgery, such as heart, brain, or kidney problems?\n\nIs RIPC safe to use during emergency ATAAD surgery?\n\nResearchers will compare the RIPC group to a control group (who will receive a placebo) to see if RIPC can reduce complications after surgery.\n\nParticipants will:\n\nReceive either RIPC or a sham intervention during their surgery.\n\nBe monitored for up to 30 days after surgery for complications.\n\nHave follow-up visits at 3 months, 1 year, and then yearly for up to 5 years to track their recovery.",[104],"Aortic Dissection Type A",[106,107,108,109],"Remote Ischaemic Conditioning","ischemia reperfusion injury","emergency surgery","major adverse outcomes","2026-01-26",{"date":112,"type":113},"2026-02-03","ACTUAL",{"date":115,"type":113},"2026-01-05",{"date":117,"type":98},"2032-12-31",{"name":5,"class":6},3]