[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100503085":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":41,"responsibleParty":59,"collaborators":26,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":26,"enrollmentInfo":71,"targetDuration":26,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":26,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Universität Münster","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Group","EXPERIMENTAL","Remote ischemic preconditioning (RIPC) Three Cycles of 5-min upper limb ischemia. If there is no response this will be followed by 2 cycles of 10-min upper-limb ischemia.",[13],"Procedure: Remote ischemic preconditioning (RIPC)",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","SHAM_COMPARATOR","Three cycles of 5- min upper limb sham ischemia.",[19],"Procedure: Sham RIPC",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Remote ischemic preconditioning (RIPC)","3 cycles of 5 min inflation of a blood-pressure cuff to 200 millimetres of mercury (mmHG) (or at least to a pressure 50 mmHG higher than the systolic arterial pressure) to one upper arm followed by 5 min reperfusion with the cuff deflated. In Non-Responder two additional cycles of 10 min cuff inflation will be performed.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sham RIPC","3 cycles of 5 min inflation of a blood-pressure cuff to 20 mmHG to one upper arm followed by 5 min reperfusion with the cuff deflated. In Non-Responder two additional cycles of 10 min cuff inflation will be performed",[15],[32],{"name":33,"affiliation":34,"role":35},"Melanie Meersch-Dini, MD","University Hospital Muenster, Dept. of Anesthesiology, Intensive Care Therapy and Pain Medicine","PRINCIPAL_INVESTIGATOR",[37],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","+49-251-8347255","meersch@uni-muenster.de",[42],{"facility":43,"status":44,"city":45,"state":26,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"University Hospital Münster; Department of Anesthesiology, Intensive Care Medicine and Pain Medicine","RECRUITING","Münster","48149","Germany","DE",{"type":50,"coordinates":51},"Point",[52,53],7.62571,51.96236,{"lat":53,"lon":52},[56],{"name":57,"role":38,"phone":26,"phoneExt":26,"email":58},"Meersch, MD","aki@uni-muenster.de",{"type":60,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100503085","remote-ischemic-preconditioning-in-septic-patients-100503085",false,"NCT05830669","Remote Ischemic Preconditioning in Septic Patients","Effect of Remote Ischemic Preconditioning in Septic Patients on Cell Cycle Arrest Biomarkers - the RIPC-ICU Randomized Clinical Trial","RIPC-ICU","Inclusion Criteria:\n\n* Adult patients (age ≥18 years)\n* Critically ill patients with sepsis \\\u003C 12 hours\n* Invasive ventilation for at least 24 hours (propofol-free-sedation) and\u002For vasopressor therapy\n* Unrestricted intensive care for at least 72 hours\n* Written informed consent\n\nExclusion Criteria:\n\n* Pre-existing AKI\n* (Glomerulo-)nephritis, interstitial nephritis, vasculitis\n* Chronic kidney disease with estimated glomerular filtration rate (eGFR) \\\u003C 30 ml\u002Fmin\u002F1.73m²\n* Chronic dialysis dependency\n* Kidney transplant in the last 12 months\n* Oral antidiabetics, sulfonamides or nicorandil\n* Pregnancy or breastfeeding\n* Do-not-reanimate order\n* Participation in another interventional trial involving kidney outcomes within the last 3 months\n* Dependency on the investigator or center","ALL","18 Years",{"count":72,"type":73},64,"ESTIMATED","INTERVENTIONAL",[76],"NA","Acute kidney injury is a well-recognized complication in critically ill patients. Up to date there is no clinically established method to reduce the incidence or the severity of acute kidney injury.\n\nRemote ischemic preconditioning (RIPC) will be induced by three cycles of upper limb ischemia.\n\nThe aim of the study is to reduce the incidence of AKI by implementing remote ischemic preconditioning (identified by the urinary biomarkers tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7(IGFBP7)",[79,80,81],"Critically Ill","Acute Kidney Injury","Sepsis","2024-12-06",{"date":84,"type":85},"2024-12-12","ACTUAL",{"date":87,"type":85},"2023-05-11",{"date":89,"type":73},"2026-01",{"name":5,"class":6},1]