[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618490":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":35,"locations":45,"responsibleParty":65,"collaborators":68,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":74,"sex":79,"minAge":80,"maxAge":34,"enrollmentInfo":81,"targetDuration":34,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":48,"whyStopped":34,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Minneapolis Veterans Affairs Medical Center","FED",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active tDCS with cognitive training","EXPERIMENTAL","Participants will receive 10 sessions of cognitive training concurrent with transcranial direct current stimulation (45 minutes of cognitive training with tDCS applied for first 20 minutes of session; tDCS: 2mA, 30s ramp up\u002Fdown, anode at F3, cathode at F4).",[13],"Combination Product: Active tDCS and Cognitive Training Intervention",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham tDCS with cognitive training","SHAM_COMPARATOR","Participants will receive 10 sessions of cognitive training concurrent with sham transcranial direct current stimulation (45 minutes of cognitive training with sham tDCS: 2mA current will be ramped down immediately after the initial 30s ramp up period and then at 20 minutes ramped up and down as done at the beginning, anode at F3, cathode at F4).",[19],"Combination Product: Sham tDCS and Cognitive Training Intervention",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"COMBINATION_PRODUCT","Active tDCS and Cognitive Training Intervention","Forty-five minutes of cognitive training concurrent with 2 mAmps of anodal stimulation applied to the left frontal cortex for the first 20 minutes of the session.",[9],[27],"tDCS",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Sham tDCS and Cognitive Training Intervention","Forty-five minutes of cognitive training concurrent with sham tDCS (30 secs ramp up\u002Framp down of current at beginning and end of session).",[15],[33],"sham tDCS",null,[36,41],{"name":37,"role":38,"phone":39,"phoneExt":34,"email":40},"Casey S Gilmore, PhD","CONTACT","612-629-7466","casey.gilmore2@va.gov",{"name":42,"role":38,"phone":43,"phoneExt":34,"email":44},"Laura Hemmy, PhD","612-467-2323","laura.hemmy@va.gov",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Minneapolis VA Health Care System","RECRUITING","Minneapolis","Minnesota","55417","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-93.26384,44.97997,{"lat":58,"lon":57},[61,62,63],{"name":37,"role":38,"phone":39,"phoneExt":34,"email":40},{"name":42,"role":38,"phone":43,"phoneExt":34,"email":44},{"name":37,"role":64,"phone":34,"phoneExt":34,"email":34},"PRINCIPAL_INVESTIGATOR",{"type":64,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"Casey Gilmore, PhD","Principal Investigator",[69],{"name":70,"class":71},"Center for Veterans Research and Education","OTHER","100618490","remote-stimulation-and-training-to-advance-recovery-from-tbi-in-seniors-100618490",false,"NCT07332299","Remote Stimulation and Training to Advance Recovery From TBI in Seniors","ReSTART","Inclusion Criteria:\n\n1. Veterans age 65 and older.\n2. History of mild TBI (as defined by the DOD\u002FVA criteria used in conjunction with the OSU TBI-ID) sustained at least 3 months prior to enrollment.\n3. Self-reported or medically documented attention and\u002For concentration difficulties.\n4. Stable dose of all prescription and non-prescription medications that may impact cognition or brain chemistry (except for PRN medication) for at least 3 weeks prior to the baseline session (Visit 1), in the medical opinion of the principal investigator.\n5. Capable and willing to provide voluntary informed consent, in the medical opinion of the principal investigator.\n\nExclusion Criteria:\n\n1. Presence of a medical, psychiatric, physical or non-physical disease, disorder, condition, injury, disability or pre-existent history such that study participation, in the opinion of the principal investigator: (a) may pose a significant risk to the participant, (b) raises the possibility that the participant is unlikely to successfully complete all the requirements of the study according to the study protocol, or (c) might adversely impact the integrity of the data or the validity of the study results. Specific conditions include (but are not limited to) a history of brain tumor near the stimulation site, brain surgery, stroke with current sequalae, epilepsy, multiple sclerosis, Huntington's Disease, ALS, ataxia, aphasia, Alzheimer's Disease, and dementia.\n2. Moderate to severe cognitive impairment with MoCA score (assessed upon enrollment) less than 15.\n3. Prior treatment with ECT or neuromodulation in the last 12 months.\n4. Current severe alcohol or substance use disorder with evidence of withdrawal or tolerance within the past 6 months, based on psychiatric history and\u002For a review of available medical records.\n5. Psychosis or mania within 30 days of enrollment, as determined by the principal investigator, based on psychiatric history and\u002For a review of available medical records.\n6. Contraindications for tDCS (e.g., metallic cranial plates\u002Fscrews or implanted device, eczema or skin lesions on scalp near electrode site, etc.).\n7. No or limited internet connection in their home.","ALL","65 Years",{"count":82,"type":83},40,"ESTIMATED","INTERVENTIONAL",[86],"NA","The goal of this clinical trial is to learn if combining brain stimulation with cognitive training can improve thinking skills in older adults who have had a traumatic brain injury (TBI).\n\nThe main questions are:\n\n* Does transcranial direct current stimulation (tDCS) make cognitive training more effective for improving attention, memory, and decision-making?\n* Is this type of home-based program feasible and acceptable for older adults with TBI?\n\nResearchers will compare two groups: one group will receive active tDCS during cognitive training, and the other group will receive sham (placebo) tDCS during cognitive training.\n\nParticipants will:\n\n* Complete computer-based cognitive training exercises (BrainHQ) to practice attention, memory, and decision-making.\n* Receive either active or sham tDCS during training sessions.\n* Complete assessments before and after the program to measure changes in thinking and daily functioning.",[89,90],"Traumatic Brain Injury","Aging Related Cognitive Decline",[92,93,94,89],"Aging","Cognitive Training","Transcranial Direct Current Stimulation","2026-01-08",{"date":97,"type":98},"2026-01-12","ACTUAL",{"date":100,"type":83},"2026-01-15",{"date":102,"type":83},"2027-09",{"name":5,"class":6},1]