[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100456016":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":106,"collaborators":108,"id":119,"slug":120,"hasResults":121,"nctId":122,"briefTitle":123,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":121,"sex":126,"minAge":127,"maxAge":18,"enrollmentInfo":128,"targetDuration":18,"studyType":131,"phases":132,"briefSummary":134,"conditions":135,"keywords":18,"overallStatus":39,"whyStopped":18,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":150},{"fullName":5,"class":6},"Duke University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"REmotely Monitored, Mobile health supported Multidomain Rehabilitation Program with HIIT","EXPERIMENTAL","Patients will receive our REmotely monitored, Mobile health supported Multidomain Rehabilitation Program with High Intensity Interval Training Program (REMM-HIIT) with iWatch\u002FiPhone.",[13],"Behavioral: REmotely monitored, Mobile health supported Multidomain Rehabilitation Program with High Intensity Interval Training (REMM-HIIT)",{"label":15,"type":16,"description":17,"interventionNames":18},"Exercise education without personalized sessions or feedback","NO_INTERVENTION","Patients will receive an exercise handout and iWatch\u002FiPhone. Patients return home to exercise without personalized instruction and coaching.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","REmotely monitored, Mobile health supported Multidomain Rehabilitation Program with High Intensity Interval Training (REMM-HIIT)","REmotely Monitored, Mobile health-supported, High Intensity Interval Training consists of remotely monitored tailored, structured, progressive multidomain physical rehabilitation \\& personalized instruction \\& coaching.\n\nPatients complete 3 structured exercise sessions\u002Fweek consisting of HIIT, strength, balance, and mobility exercises. Following warmup, patients increase workload at a heart rate corresponding to 95% VO2peak for 1-minute before returning to warm-up speed for 1-minute at a heart rate corresponding to 60% VO2peak.\n\nStrength includes functional strengthening exercises for lower extremities \\& general resistance exercises for major muscle groups.\n\nBalance incorporates static \\& dynamic exercises, including progressively narrowing base of support with eyes open or closed, reaching forward \\& backward starting within base of support \\& progressing to outside base of support.\n\nMobility rehabilitation includes dynamic start\u002Fstop while walking and changing direction while walking.",[9],[26],{"name":27,"affiliation":28,"role":29},"Paul Wischmeyer, MD","Duke Clinical Research Institute","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":18,"email":35},"Marjan Cobbaert, MPH","CONTACT","919-668-9740","marjan.cobbaert@duke.edu",[37,54,67,80,93],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"University of Alabama at Birmingham","RECRUITING","Birmingham","Alabama","35233","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-86.80249,33.52066,{"lat":49,"lon":48},[52],{"name":53,"role":33,"phone":18,"phoneExt":18,"email":18},"Peter Morris, MD",{"facility":55,"status":39,"city":56,"state":57,"zip":58,"country":43,"countryCode":44,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"University of Kentucky","Lexington","Kentucky","40536",{"type":46,"coordinates":60},[61,62],-84.47772,37.98869,{"lat":62,"lon":61},[65],{"name":66,"role":33,"phone":18,"phoneExt":18,"email":18},"Kirby Mayer, PT, DPT, PhD",{"facility":68,"status":39,"city":69,"state":70,"zip":71,"country":43,"countryCode":44,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"Duke University Health System","Durham","North Carolina","27710",{"type":46,"coordinates":73},[74,75],-78.89862,35.99403,{"lat":75,"lon":74},[78],{"name":79,"role":33,"phone":18,"phoneExt":18,"email":18},"Amy Pastva, PT, PhD",{"facility":81,"status":39,"city":82,"state":83,"zip":84,"country":43,"countryCode":44,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"The Ohio State University Wexner Medical Center","Columbus","Ohio","43201",{"type":46,"coordinates":86},[87,88],-82.99879,39.96118,{"lat":88,"lon":87},[91],{"name":92,"role":33,"phone":18,"phoneExt":18,"email":18},"Nathan Brummel, MD",{"facility":94,"status":39,"city":95,"state":96,"zip":97,"country":43,"countryCode":44,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"Vanderbilt University Medical Center","Nashville","Tennessee","37203",{"type":46,"coordinates":99},[100,101],-86.78444,36.16589,{"lat":101,"lon":100},[104],{"name":105,"role":33,"phone":18,"phoneExt":18,"email":18},"E Wesley Ely, MD",{"type":107,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[109,112,113,115,116,117],{"name":110,"class":111},"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","NIH",{"name":94,"class":6},{"name":114,"class":6},"Ohio State University",{"name":55,"class":6},{"name":38,"class":6},{"name":118,"class":6},"Florida Atlantic University","100456016","remotely-monitored-mobile-health-supported-multidomain-rehabilitation-program-with-high-intensity-interval-training-for-covid-19-100456016",false,"NCT05218083","REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19","REMM-HIIT-CoV","Inclusion Criteria:\n\n* Primary diagnosis of COVID-19 requiring hospital admission\n* Discharged or expected to be discharged directly home from the hospital (not to a skilled nursing facility, inpatient rehabilitation center, or long-term acute care hospital)\n* Able to ambulate with or without a gait aid prior to hospital discharge\n* Age ≥ 18 years\n\nExclusion Criteria:\n\n* Hospital discharge \\> 60 days unless readmitted to hospital in first 30 days, then 60 day window restarts and new exclusion is last hospital discharge \\> 60 days\n* Not ambulating independently prior to COVID-19 illness (use of a gait aid permitted)\n* Functional impairment resulting in inability to exercise at baseline\n* Inability or unwillingness to comply with the study requirements or unable or unwilling to follow coaching via mobile-health iPhone interaction\n* Any absolute contraindications to exercise, including but not limited to:\n\n  * Recent (\\\u003C 5 days) acute primary cardiac event\n  * Unstable Angina\n  * Uncontrolled dysrhythmias causing symptoms or hemodynamic compromise\n  * Uncontrolled hypertension over 255 mmHg Systolic or 155 diastolic blood pressure\n  * Symptomatic aortic stenosis\n  * Uncontrolled symptomatic heart failure\n  * Acute myocarditis or pericarditis\n  * Suspected or known dissecting aneurysm\n* Any adverse changes during GXT (i.e., persistent oxygen saturation drop below 88% while on prescribed oxygen therapy or significant hypotension such as mean arterial blood pressure \\\u003C 60 mmHg on 2 consecutive readings within 1 minute)\n* High risk for non-adherence as determined by screening evaluation\n* Any condition, including cognitive impairment, that, in the judgment of the investigator, precludes participation because it could affect subject safety or ability of subject to complete the study\n* Pregnant","ALL","18 Years",{"count":129,"type":130},120,"ESTIMATED","INTERVENTIONAL",[133],"NA","Multicenter, prospective, randomized controlled trial providing mobile health supported physical rehabilitation to 120 patients who have been critically ill with COVID-19 and who complete at least one exercise session.",[136,137,138,139,140],"COVID-19","Critical Illness","ICU Acquired Weakness","PICS","Cardiorespiratory Fitness","2026-05-27",{"date":143,"type":144},"2026-05-28","ACTUAL",{"date":146,"type":144},"2023-02-23",{"date":148,"type":130},"2027-04-01",{"name":5,"class":6},5]