[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612951":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":39,"centralContacts":46,"locations":52,"responsibleParty":87,"collaborators":91,"id":95,"slug":96,"hasResults":97,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":34,"eligibilityCriteria":101,"healthyVolunteers":97,"sex":102,"minAge":103,"maxAge":34,"enrollmentInfo":104,"targetDuration":34,"studyType":107,"phases":108,"briefSummary":110,"conditions":111,"keywords":118,"overallStatus":55,"whyStopped":34,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":140},{"fullName":5,"class":6},"University of Texas at Austin","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Language Therapy with Active Stimulation","EXPERIMENTAL","Participants will receive virtual language therapy in conjunction with active remotely-supervised transcranial direct current stimulation.",[13,14],"Behavioral: Lexical Retrieval Cascade Treatment","Device: Remotely Supervised Transcranial Direct Current Stimulation- Active",{"label":16,"type":17,"description":18,"interventionNames":19},"Language Therapy with Sham Stimulation","SHAM_COMPARATOR","Participants will receive virtual language therapy in conjunction with sham remotely-supervised transcranial direct current stimulation.",[13,20],"Device: Remotely Supervised Transcranial Direct Current Stimulation - Sham",[22,29,35],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"BEHAVIORAL","Lexical Retrieval Cascade Treatment","Participants work on producing spoken and written names of personally-relevant target items. Treatment focuses on the use of strategies that capitalize on spared cognitive-linguistic abilities to support word retrieval. The participant completes two (one hour each) teletherapy sessions per week with a clinician plus 30 minutes of additional independent, computer-based practice exercises 3 times per week.",[9,16],[28],"LRCT",{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"DEVICE","Remotely Supervised Transcranial Direct Current Stimulation- Active","tDCS is a type of non-invasive brain stimulation. 2.0 milliamp (mA) of current will be delivered via electrodes in saline-soaked sponges placed on the left and right sides of the head. The stimulation will last 20 minutes and will occur 5 times weekly, in the participant's home setting, while the participant engages in computer-delivered speech-language training. Sessions are monitored by study personnel.",[9],null,{"type":30,"name":36,"description":37,"armGroupLabels":38,"otherNames":34},"Remotely Supervised Transcranial Direct Current Stimulation - Sham","tDCS is a type of non-invasive brain stimulation. 2.0 milliamp (mA) of current will be delivered via electrodes in saline-soaked sponges placed on the left and right sides of the head. In sham stimulation, current will be delivered for a brief period of time and then turned off. Sham stimulation will last 20 minutes and will occur 5 times weekly, in the participant's home setting, while the participant engages in computer-delivered speech-language training. Sessions are monitored by study personnel.",[16],[40,43],{"name":41,"affiliation":5,"role":42},"Maya L Henry, PhD","PRINCIPAL_INVESTIGATOR",{"name":44,"affiliation":45,"role":42},"Jessica D Richardson, PhD","University of New Mexico",[47],{"name":48,"role":49,"phone":50,"phoneExt":34,"email":51},"Aphasia Lab Research Coordinator","CONTACT","512-471-3420","aphasialab@austin.utexas.edu",[53,73],{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"UCSF Memory and Aging Cener","RECRUITING","San Francisco","California","94158","United States","US",{"type":62,"coordinates":63},"Point",[64,65],-122.41942,37.77493,{"lat":65,"lon":64},[68,71],{"name":69,"role":49,"phone":34,"phoneExt":34,"email":70},"Willa Keegan-Rodewald, M.A.","willa.keeganrodewald@ucsf.edu",{"name":72,"role":42,"phone":34,"phoneExt":34,"email":34},"Maria Luisa Gorno-Tempini, MD, PhD",{"facility":74,"status":55,"city":75,"state":76,"zip":77,"country":59,"countryCode":60,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"University of Texas","Austin","Texas","78712",{"type":62,"coordinates":79},[80,81],-97.74306,30.26715,{"lat":81,"lon":80},[84,86],{"name":85,"role":49,"phone":50,"phoneExt":34,"email":51},"Aphasia Lab Research Coordinator, MS",{"name":41,"role":42,"phone":34,"phoneExt":34,"email":34},{"type":88,"investigatorFullName":89,"investigatorTitle":90,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"SPONSOR_INVESTIGATOR","Maya Henry","Associate Professor, Associate Dean for Research",[92],{"name":93,"class":94},"National Institute on Aging (NIA)","NIH","100612951","remotely-supervised-neuromodulation-in-ppa-100612951",false,"NCT07260253","Remotely-supervised Neuromodulation in PPA","Investigating the Benefits of Remotely-Supervised Neuromodulation In Primary Progressive Aphasia","Inclusion Criteria:\n\n* Meets diagnostic criteria for primary progressive aphasia (PPA)\n* Meets diagnostic criteria for logopenic variant PPA\n* Attains score of 15 or higher on the Mini-Mental State Examination\n* Has adequate hearing and vision (with hearing or vision aids, if needed)\n* Is able to travel to research site and undergo MRI brain scan\n* Has access to high speed internet and basic experience using a computer and the internet\n* Is a fluent speaker of English\n* Has a study partner who can co-enroll in the study, attend pre-treatment training at the research site, and be present for teleconference meetings, as needed\n\nExclusion Criteria:\n\n* Speech and language deficits better accounted for by another neurological disorder\n* Does not meet diagnostic criteria for logopenic variant PPA\n* Scores less than 15 on the Mini-Mental State Examination\n* Does not have a study partner who can co-enroll in the study\n* Has contraindications for tDCS or MRI scan (History of seizures, head injury, craniotomy, skull surgery or fracture; History of severe or frequent migraines; Metallic implant in head or any metal in head; Pacemaker or cardioverter-defibrillator or any other stimulator; Chronic skin problems; Pregnancy)\n* Has a history of stroke, epilepsy, or significant brain injury","ALL","40 Years",{"count":105,"type":106},80,"ESTIMATED","INTERVENTIONAL",[109],"NA","The goal of this clinical trial is to learn whether home-based brain stimulation combined with virtual speech-language therapy can improve communication abilities in adults with logopenic variant primary progressive aphasia (lvPPA), a language disorder most often caused by Alzheimer's disease.\n\nThe main questions the study aims to answer are:\n\n* Is combining remotely supervised transcranial direct current stimulation (tDCS) with virtual speech-language therapy feasible and acceptable for people with lvPPA?\n* Does this combined treatment lead to improvements in communication compared to speech-language therapy with sham (placebo) stimulation?\n* Do individual brain characteristics help predict who benefits most from this treatment?\n\nResearchers will compare participants who receive active tDCS plus virtual speech-language therapy to participants who receive sham (placebo) tDCS plus virtual speech-language therapy to see if active brain stimulation enhances communication outcomes.\n\nParticipants will:\n\n* Complete speech-language therapy sessions delivered by video visit.\n* Receive either active or sham tDCS that is remotely supervised and completed at home.\n* Complete language and cognitive testing before and after treatment.\n* Undergo brain imaging and other assessments to help understand treatment response.",[112,113,114,115,116,117],"Primary Progressive Aphasia(PPA)","Progressive Aphasia","Progressive Aphasia in Alzheimer's Disease","Logopenic Progressive Aphasia (LPA)","Logopenic Variant Primary Progressive Aphasia","Logopenic Variant of Primary Progressive Aphasia (LPA)",[119,120,121,122,123,124,125,126,127,128,129,130],"lvPPA","PPA","logopenic variant PPA","transcranial direct-current stimulation","tDCS","neuromodulation","speech therapy","speech-language pathology","logopenic","teletherapy","remote","virtual","2026-06-24",{"date":133,"type":134},"2026-06-29","ACTUAL",{"date":136,"type":134},"2026-04-15",{"date":138,"type":106},"2029-08",{"name":89,"class":6},2]