[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100464338":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":30,"responsibleParty":71,"collaborators":10,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":10,"eligibilityCriteria":79,"healthyVolunteers":75,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":10,"studyType":86,"phases":10,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":62,"whyStopped":10,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"RenJi Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"renal biopsy",null,"Standard percutaneous biopsy has been performed in all participants. Light microscope, fluorescence microscope and electron microscope were used for assessment of kidney issue",[13],"Behavioral: renal biospy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"BEHAVIORAL","renal biospy","Standard percutaneous biopsy has been performed in all participants. Modification of treatment will be jointly decided by hepatologists and nephrologists based on the pathological results. All participants will be followed up for 96 weeks.",[9],[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Shan Mou, Dr","CONTACT","13918221242","shan_mou@126.com",{"name":27,"role":23,"phone":28,"phoneExt":10,"email":29},"Haijiao Jin, Dr","13917735313","jinhaijiao1108@126.com",[31,61],{"facility":32,"status":33,"city":34,"state":10,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine","NOT_YET_RECRUITING","Shanghai","200127","China","CN",{"type":39,"coordinates":40},"Point",[41,42],121.45806,31.22222,{"lat":42,"lon":41},[45,46,47,49,51,54,56,57,59],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},{"name":27,"role":23,"phone":28,"phoneExt":10,"email":29},{"name":22,"role":48,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"name":50,"role":48,"phone":10,"phoneExt":10,"email":10},"Jianjun Zhang, Dr",{"name":52,"role":53,"phone":10,"phoneExt":10,"email":10},"Qin Wang, Dr","SUB_INVESTIGATOR",{"name":55,"role":53,"phone":10,"phoneExt":10,"email":10},"Yongbing Qian, Dr",{"name":27,"role":53,"phone":10,"phoneExt":10,"email":10},{"name":58,"role":53,"phone":10,"phoneExt":10,"email":10},"Jiang Zhang, Dr",{"name":60,"role":53,"phone":10,"phoneExt":10,"email":10},"Yao Xu, Dr",{"facility":32,"status":62,"city":34,"state":10,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":63,"geoPoint":65,"contacts":66},"RECRUITING",{"type":39,"coordinates":64},[41,42],{"lat":42,"lon":41},[67,69],{"name":27,"role":23,"phone":68,"phoneExt":10,"email":29},"+8613917735313",{"name":70,"role":48,"phone":10,"phoneExt":10,"email":10},"Shan Mou",{"type":48,"investigatorFullName":70,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Professor","100464338","renal-biopsies-in-post-liver-transplantation-patients-with-renal-impairment-100464338",false,"NCT05326399","Renal Biopsies in Post-liver Transplantation Patients With Renal Impairment","Renal Biopsies in Post-liver Transplantation Patients With Renal Impairment: a Single-center, Prospective Cohort Study","Inclusion Criteria:\n\n* age 18-75 years\n* patients received liver transplantation\n* new onset of proteinuria(defined as 24-hour proteinuria\\>1g\u002F24h, or Urinary albumin creatinine ratio(UACR)\\>300mg\u002Fg on at least two occasions), and\u002For renal impairment: eGFR \\\u003C60 mL\u002Fmin\u002F1.73 m² at least two occasions, and\u002For serum creatinine increase ≥50% from baseline\n* have received renal biopsy in the past 3 months\n* Signed informed consent form(ICF)\n\nExclusion Criteria:\n\n* patients received renal transplantation\n* hepatic failure\n* severe bleeding risk or platelet \\\u003C70\\*109\u002FL\n* chronic kidney insufficiency with eGFR\\\u003C30ml\u002Fmin·1.73m2,or kidney atrophy, or solitary kidney, or medullary sponge kidney, or polycystic kidney, or obstructive nephropathy\n* uncontrolled mental disease or unable to cooperate during operation\n* Pregnancy or lactation\n* not suitable for this study judged by investigaters","ALL","18 Years","75 Years",{"count":84,"type":85},369,"ESTIMATED","OBSERVATIONAL","Investigators will conduct this single-center, prospective cohort study to explore the prevalence and risk factors of renal function progression in post-liver transplantation patients with renal impairment after renal biospy and to understand the the pathology of kidney disease in post-liver transplantation patients with renal impairment.",[89,90],"Liver Transplantation","Renal Insufficiency, Chronic",[92,9,93],"Liver transplantation","chronic kidney disease","2025-11-23",{"date":96,"type":97},"2025-11-28","ACTUAL",{"date":99,"type":97},"2022-06-01",{"date":101,"type":85},"2030-12-31",{"name":5,"class":6},2]