[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100594124":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":28,"responsibleParty":43,"collaborators":47,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":10,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":62,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":71,"overallStatus":77,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Ankara City Hospital Bilkent","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"CASE GROUP",null,"During the operation, heart rate (HR) and peripheral oxygen saturation (SpO₂) were continuously monitored. Systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and mean arterial pressure (MAP) were measured and recorded every 2 minutes for the first 15 minutes, then every 5 minutes thereafter. Hypotension was defined as a ≥30% decrease in MAP from baseline or systolic blood pressure \\\u003C100 mmHg. Patients who developed hypotension within the first four measurements were included in the hypotension group. Patients who developed hypotension in later measurements were excluded from the study to avoid confusion with bleeding-related hypotension. A 5 mg bolus of ephedrine was administered to raise the MAP to 80% or more of the baseline level within 60 seconds. Surgical duration, amount of fluids administered, duration and number of hypotensive episodes, total dose of ephedrine, estimated blood loss, use of additional uterotonics or tranexamic acid, neonatal weight, and Apgar.",{"label":13,"type":10,"description":14,"interventionNames":10},"CONTROL GROUP","During the operation, the patient's heart rate (HR) and peripheral oxygen saturation (SpO₂) were continuously monitored. Systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and mean arterial pressure (MAP) were measured and recorded every 2 minutes for the first 15 minutes, and then every 5 minutes thereafter. Patients whose MAP did not decrease by 30% or more from the baseline value were considered the control group",[16],{"name":17,"affiliation":5,"role":18},"Nihan Aydın Güzey","PRINCIPAL_INVESTIGATOR",[20,25],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Cahide Çağlayan, Dr","CONTACT","+905547542106","cahide.gulsen@hotmail.com",{"name":17,"role":22,"phone":26,"phoneExt":10,"email":27},"+905056496231","nihanaydinguzey@gmail.com",[29],{"facility":30,"status":10,"city":31,"state":31,"zip":32,"country":33,"countryCode":10,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Ankara City Hospital","Ankara","06800","Turkey (Türkiye)",{"type":35,"coordinates":36},"Point",[37,38],32.85427,39.91987,{"lat":38,"lon":37},[41],{"name":30,"role":22,"phone":42,"phoneExt":10,"email":24},"+905549542106",{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Nihan Aydin Guzey","Assoc.Prof. MD",[48],{"name":5,"class":6},"100594124","renal-functions-in-preeclamptic-pregnant-women-using-neutrophil-gelatinase-associated-lipocalin-ngal-and-standard-renal-function-tests-100594124",false,"NCT07015359","Renal Functions in Preeclamptic Pregnant Women Using Neutrophil Gelatinase-associated Lipocalin (NGAL) and Standard Renal Function Tests","Evaluation of the Effect of Spinal Anesthesia-Induced Hypotension on Renal Functions in Preeclamptic Pregnant Women Using Neutrophil Gelatinase-associated Lipocalin (NGAL) and Standard Renal Function Tests","Inclusion Criteria:\n\n* Patients classified as ASA physical status II-III\n* Pregnant women aged 18-45 years, diagnosed with preeclampsia and scheduled for elective cesarean section, will be included in the study.\n\nExclusion Criteria:\n\n* Patients who are unable to read, understand, or sign the informed consent form\n* Patients with a diagnosed renal disease\n* Patients who do not wish to participate in the study\n* Patients with ASA physical status greater than III\n* Patients younger than 18 or older than 45 years\n* Patients requiring sedation or undergoing general anesthesia\n* Patients with cardiac instability\n* Patients with known arrhythmias","FEMALE","18 Years","45 Years",{"count":60,"type":61},46,"ESTIMATED","6 Months","OBSERVATIONAL","Acute kidney injury (AKI) is a significant postoperative complication. Risk factors for AKI include impaired renal perfusion, decreased functional renal reserve, as well as advanced age, peripheral arterial disease, diabetes mellitus, renovascular disease and congestive heart failure. Mean arterial pressure (MAP) below 55-60 mmHg has been associated with postoperative AKI. Traditional diagnostic criteria for AKI include increased serum creatinine levels and oliguria. However, creatinine levels do not rise until more than half of renal function is lost. Serum and urine NGAL levels rise earlier-within 24-48 hours-making it a promising early biomarker.\n\nIn our study, hypotension is defined as systolic blood pressure \\\u003C100 mmHg or a \\>30% decrease in MAP. Patients requiring ephedrine under these conditions will be evaluated as the hypotension group and compared with non-hypotensive patients in terms of NGAL, BUN (blood urea nitrogen), creatinine, and GFR (Glomerular Filtration Rate) values at baseline and at the 4th postoperative hour.",[66,67,68,69,70],"Anesthesia","Spinal Aneshtesia","Acute Kidney Failure","Spinal Anesthesia Induced Hypotension","Preeclampsia (PE)",[72,73,74,75,76],"Preeclampsia","Hypotension","NGAL","Creatinine","AKI","NOT_YET_RECRUITING","2025-06-08",{"date":80,"type":81},"2025-06-11","ACTUAL",{"date":78,"type":61},{"date":84,"type":61},"2025-10-20",{"name":45,"class":6},1]