[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586567":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":10,"centralContacts":29,"locations":35,"responsibleParty":51,"collaborators":10,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":62,"maxAge":10,"enrollmentInfo":63,"targetDuration":10,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":10,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"King's College Hospital NHS Trust","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"Traumatic haemorrhagic shock",null,[12,13,14],"Device: Ultrasound (including contrast enhanced ultrasound)","Device: Sublingual incident dark field videomicroscopy","Device: Urinary oxygen tension.",[16,21,25],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"DEVICE","Ultrasound (including contrast enhanced ultrasound)","Ultrasound measures: contrast enhanced ultrasound (CEUS) of the kidney, venous excess ultrasound (VExUS), echocardiography",[9],{"type":17,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"Sublingual incident dark field videomicroscopy","Sublingual incident dark field (IDF) videomicroscopy",[9],{"type":17,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Urinary oxygen tension.","Continuous urinary oxygen tension",[9],[30],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"Sam Hutchings","CONTACT","+442032994957","sam.hutchings@nhs.net",[36],{"facility":37,"status":38,"city":39,"state":10,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"King's College Hospital","RECRUITING","London","SE5 9RS","United Kingdom","UK",{"type":44,"coordinates":45},"Point",[46,47],-0.12574,51.50853,{"lat":47,"lon":46},[50],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100586567","renal-perfusion-and-the-development-of-aki-following-traumatic-injury-100586567",false,"NCT06917053","Renal Perfusion and the Development of AKI Following Traumatic Injury","Renal Perfusion and the Development of AKI Following Traumatic Injury - A Longitudinal Observational Cohort Study","PERTAKI","Inclusion Criteria:\n\n* Age \\> 18 years\n* Within 24 hours of ICU admission following traumatic injury\n* Received any blood products during initial resuscitation\n* Lactate \\> 2 mmol\u002Fl at any stage prior to study enrolment\n\nExclusion Criteria:\n\n* Known intolerance to Sonovue or any other ultrasound contrast agent\n* Patients with un-survivable injuries \u002F not expected to survive 24 hours in whom the intent of treatment is palliative\n* Known CKD 4 or end stage renal failure\n* Pregnancy","ALL","18 Years",{"count":64,"type":65},20,"ESTIMATED","OBSERVATIONAL","Acute kidney injury (AKI) is a complication of traumatic haemorrhagic shock (THS) and together these conditions increase mortality risk. Although septic shock patients who develop severe AKI are known to develop hypoperfusion of the renal cortex, little is known regarding intra-renal perfusion changes in THS. The aim of the current study is to investigate the effects of THS on renal microcirculatory perfusion.",[69,70,71],"Traumatic Haemorrhagic Shock","AKI (Acute Kidney Injury) Due to Trauma","AKI - Acute Kidney Injury","2025-04-01",{"date":74,"type":75},"2025-04-08","ACTUAL",{"date":77,"type":75},"2024-04-13",{"date":79,"type":65},"2026-07",{"name":5,"class":6},1]