[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553181":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":42,"responsibleParty":93,"collaborators":96,"id":100,"slug":101,"hasResults":102,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":25,"eligibilityCriteria":106,"healthyVolunteers":102,"sex":107,"minAge":108,"maxAge":25,"enrollmentInfo":109,"targetDuration":25,"studyType":112,"phases":113,"briefSummary":115,"conditions":116,"keywords":122,"overallStatus":44,"whyStopped":25,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":131,"completionDateStruct":132,"leadSponsor":134,"locationsCount":135},{"fullName":5,"class":6},"Peking University First Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Repetitive Transcranial Magnetic Stimulation Group","EXPERIMENTAL","Repeated transcranial magnetic stimulation (rTMS) over left dorsolateral prefrontal cortex (DLPFC) for a 5-day period (1 day before surgery and 4 consecutive days after surgery, twice daily \\[10-12 am and 6-8 pm\\], no intervention on the day of the surgery). Parameters of rTMS: \"8\" shaped coil, 10 Hz, 80% resting motor threshold (RMT), 2000 pulses (5s × 40 trains, 25 s interval), 20 minutes.",[13],"Device: Repetitive transcranial magnetic stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham Stimulation Group","SHAM_COMPARATOR","Sham repeated transcranial magnetic stimulation (rTMS) over left dorsolateral prefrontal cortex (DLPFC) for a 5-day period (1 day before surgery and 4 consecutive days after surgery, twice daily \\[10-12 am and 6-8 pm\\], no intervention on the day of the surgery). Parameters of rTMS: \"8\" shaped sham coil, 10 Hz, 80% resting motor threshold (RMT), 2000 pulses (5s × 40 trains, 25 s interval), 20 minutes.",[19],"Device: Sham stimulation",[21,26],{"type":22,"name":23,"description":11,"armGroupLabels":24,"otherNames":25},"DEVICE","Repetitive transcranial magnetic stimulation",[9],null,{"type":22,"name":27,"description":17,"armGroupLabels":28,"otherNames":25},"Sham stimulation",[15],[30],{"name":31,"affiliation":5,"role":32},"Dong-Xin Wang, MD, PhD","PRINCIPAL_INVESTIGATOR",[34,38],{"name":31,"role":35,"phone":36,"phoneExt":25,"email":37},"CONTACT","8610 83572784","wangdongxin@hotmail.com",{"name":39,"role":35,"phone":40,"phoneExt":25,"email":41},"Hao Kong, MD","8610 83575138","konghao2438@126.com",[43,60,77],{"facility":5,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Beijing","Beijing Municipality","100034","China","CN",{"type":51,"coordinates":52},"Point",[53,54],116.39723,39.9075,{"lat":54,"lon":53},[57,58,59],{"name":31,"role":35,"phone":36,"phoneExt":25,"email":37},{"name":39,"role":35,"phone":40,"phoneExt":25,"email":41},{"name":31,"role":32,"phone":25,"phoneExt":25,"email":25},{"facility":61,"status":62,"city":63,"state":64,"zip":65,"country":48,"countryCode":49,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"Peking University Shenzhen Hospital","NOT_YET_RECRUITING","Shenzhen","Guangzhou","516473",{"type":51,"coordinates":67},[68,69],114.0683,22.54554,{"lat":69,"lon":68},[72,76],{"name":73,"role":35,"phone":74,"phoneExt":25,"email":75},"Tao Luo, MD","0755 83923333","luotao_wh@yahoo.com",{"name":73,"role":32,"phone":25,"phoneExt":25,"email":25},{"facility":78,"status":62,"city":79,"state":80,"zip":81,"country":48,"countryCode":49,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"Xijing Hospital, Air Force Medical University","Xi'an","Shannxi","710032",{"type":51,"coordinates":83},[84,85],108.92861,34.25833,{"lat":85,"lon":84},[88,91],{"name":89,"role":35,"phone":25,"phoneExt":25,"email":90},"Zhi-Hong Lu, MD, PhD","deerlu23@163.com",{"name":89,"role":92,"phone":25,"phoneExt":25,"email":25},"SUB_INVESTIGATOR",{"type":32,"investigatorFullName":94,"investigatorTitle":95,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Dong-Xin Wang","Professor",[97,99],{"name":98,"class":6},"The First Affiliated Hospital of Air Force Medicial University",{"name":61,"class":6},"100553181","repetitive-transcranial-magnetic-stimulation-and-postoperative-neurocognitive-recovery-100553181",false,"NCT06482749","Repetitive Transcranial Magnetic Stimulation and Postoperative Neurocognitive Recovery","Impact of Repetitive Transcranial Magnetic Stimulation on Postoperative Neurocognitive Recovery in Older Patients With Preoperative Cognitive Impairment: A Randomized, Double-blinded, Sham-controlled Trial","Inclusion Criteria:\n\n1. Aged ≥65 years;\n2. Patients with preoperative mild to moderate cognitive impairment, defined as 9\\\u003CMontreal Cognitive Assessment (MoCA)\\\u003C26;\n3. Scheduled for elective non-cardiac surgery under general anesthesia, with an expected surgical duration of \\>2 hours;\n4. Expected to stay in hospital for at least 5 days after surgery.\n\nExclusion Criteria:\n\n1. Left-handed;\n2. Primary school education level or below;\n3. Comorbid diseases including mental illness, intellectual disability, auditory and visual dysfunction, language impairment, severe neurological disorders, or other diseases that impede the completion of evaluation;\n4. Neurosurgery;\n5. Presence of contraindications to rTMS treatment, including epilepsy, pregnant or lactating women, or with a metal or electric implanted device (e.g., deep brain stimulator, ventriculoperitoneal shunt, aneurysm clip, pacemaker, cochlear implant, or surgical staples on the scalp);\n6. Other situations that are deemed unsuitable for inclusion in the study.","ALL","65 Years",{"count":110,"type":111},568,"ESTIMATED","INTERVENTIONAL",[114],"NA","Patients with preoperative cognitive impairment are at increased risks of delayed neurocognitive recovery (DNR) and postoperative neurocognitive disorder (POCD). Repetitive transcranial magnetic stimulation (rTMS) has been used to improve cognitive function in patients with cognitive impairement. This trial is designed to compare the effects of rTMS versus sham intervention on postoperative neurocognitive function in patients with preoperative cognitive impairment.",[117,118,119,120,121],"Older Patients","Cognitive Impairment","Repetitive Transcranial Magnetic Stimulation","Delayed Neurocognitive Recovery","Postoperative Neurocognitive Disorder",[123,124,23,125,126],"Older patients","Cognitive impairment","Delayed neurocognitive recovery","Postoperative neurocognitive disorder","2025-07-28",{"date":129,"type":130},"2025-07-31","ACTUAL",{"date":127,"type":130},{"date":133,"type":111},"2029-02",{"name":5,"class":6},3]