[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621363":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":36,"centralContacts":41,"locations":27,"responsibleParty":46,"collaborators":27,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":50,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":27,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":70,"overallStatus":77,"whyStopped":27,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":27},{"fullName":5,"class":6},"Hanoi Medical University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Control Group","PLACEBO_COMPARATOR","Participants receive sham rTMS combined with the same standardized conventional motor rehabilitation program. Sham stimulation uses identical procedures, participant positioning, coil placement, session duration, and acoustic cues as active rTMS, but with the coil oriented perpendicular to the scalp to minimize effective cortical stimulation",[13,14],"Device: Sham repetitive transcranial magnetic stimulation","Other: Conventional motor rehabilitation",{"label":16,"type":17,"description":18,"interventionNames":19},"Intervention Group","EXPERIMENTAL","Participants receive active low-frequency repetitive transcranial magnetic stimulation (rTMS) combined with standardized conventional motor rehabilitation targeting both upper and lower limb function. Active rTMS targets the primary motor cortex (M1) representations relevant to the upper limb (hand area) and lower limb (leg area), with stimulation parameters delivered according to the predefined protocol.",[20,14],"Device: Active repetitive transcranial magnetic stimulation",[22,28,32],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DEVICE","Active repetitive transcranial magnetic stimulation","Active rTMS is delivered at low frequency (1 Hz), 1200 pulses per session, 20 minutes per session, once daily, five days per week, for four consecutive weeks (20 sessions). rTMS is administered immediately prior to the daily conventional rehabilitation session.\n\nUpper limb target: Stimulation is applied to the M1 hand area using a figure-of-eight coil. The stimulation site is identified using standard localization methods (EEG 10-20 system landmarks and\u002For motor evoked potentials when available).\n\nLower limb target: Stimulation is applied to the M1 leg area located near the cranial midline using a Hesed coil, with localization based on midline landmarks (near Cz) and\u002For motor evoked potentials from lower limb muscles when available.\n\nStimulation intensity is set relative to the individual motor threshold.",[16],null,{"type":23,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"Sham repetitive transcranial magnetic stimulation","Sham rTMS is administered using the same procedures, participant positioning, coil placement, stimulation duration (20 minutes), and acoustic cues as the active stimulation protocol. To minimize effective cortical stimulation, the coil is oriented perpendicular to the scalp, producing minimal magnetic field penetration while preserving the characteristic clicking sound. Sham sessions follow the same schedule as active rTMS (once daily, five days per week, for four consecutive weeks; 20 sessions).",[9],{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":27},"Conventional motor rehabilitation","Participants receive standardized conventional motor rehabilitation for 60 minutes per day, five days per week, for four consecutive weeks. Each daily session includes three components: therapeutic exercise (approximately 20 minutes), physical therapy modalities (approximately 20 minutes), and occupational therapy\u002Ftask-oriented functional training (approximately 20 minutes). The rehabilitation program is identical in content, intensity, and duration for both study arms.",[9,16],[37],{"name":38,"affiliation":39,"role":40},"Loan Phan Thi Kieu, MD, MSc","Hanoi Medical University, Hanoi, Vietnam","PRINCIPAL_INVESTIGATOR",[42],{"name":38,"role":43,"phone":44,"phoneExt":27,"email":45},"CONTACT","+84 975309081","phanthikieuloan@hmu.edu.vn",{"type":47,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR","100621363","repetitive-transcranial-magnetic-stimulation-combined-with-motor-rehabilitation-improves-motor-and-functional-outcomes-after-ischemic-stroke-100621363",false,"NCT07369648","Repetitive Transcranial Magnetic Stimulation Combined With Motor Rehabilitation Improves Motor and Functional Outcomes After Ischemic Stroke","Effects of Repetitive Transcranial Magnetic Stimulation Combined With Motor Rehabilitation on Motor and Functional Outcomes in Patients With Ischemic Stroke: A Randomized Sham-Controlled Trial","rTMS-MOTOR","Inclusion Criteria:\n\n* Aged 18 to 80 years.\n* Diagnosed with a first-ever ischemic stroke, confirmed by neuroimaging.\n* Presence of unilateral hemiparesis attributable to the first-ever ischemic stroke.\n* Time since stroke onset:\n\n  * Acute stage: \\\u003C 1 month after stroke onset\n  * Subacute stage: 1 to 6 months after stroke onset\n  * Chronic stage: \\> 6 months after stroke onset\n* Moderate neurological impairment, defined as a baseline NIHSS score between 5 and 14.\n* Cognitive ability sufficient to understand and follow instructions, indicated by a baseline MMSE score ≥ 20.\n* Medically stable and able to participate in a structured motor rehabilitation program.\n* Provided written informed consent prior to study enrollment.\n* NIHSS and MMSE scores are assessed at baseline only to characterize neurological severity and cognitive status at study entry\n\nExclusion Criteria:\n\n* Motor impairment caused by conditions other than ischemic stroke, such as musculoskeletal disorders, traumatic brain injury, Parkinson's disease, encephalitis, or other neurological conditions.\n* Contraindications to repetitive transcranial magnetic stimulation, including but not limited to intracranial metallic implants, implanted electronic medical devices (e.g., pacemaker), cochlear implants, known bleeding disorders, pregnancy, history of epilepsy or seizure disorders, severe cardiac disease, severe psychiatric or neurological disorders interfering with participation, or active skin conditions at the stimulation site.\n* History of epilepsy or seizure disorders.\n* Recurrent stroke occurring during the intervention period.\n* Refusal to participate, withdrawal of informed consent, or non-adherence to the intervention protocol.","ALL","18 Years","80 Years",{"count":60,"type":61},66,"ESTIMATED","INTERVENTIONAL",[64],"NA","Ischemic stroke is a leading cause of long-term motor disability, frequently resulting in hemiplegia and limitations in daily activities and quality of life. Motor rehabilitation is a fundamental component of post-stroke care across all stages of recovery; however, functional outcomes may vary, particularly in patients with persistent motor impairment.\n\nRepetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique that has been used as an adjunct to rehabilitation to modulate cortical excitability and potentially support motor recovery.\n\nThe purpose of this study is to evaluate the effects of low-frequency rTMS combined with conventional motor rehabilitation compared with sham rTMS combined with conventional motor rehabilitation in patients with first-ever ischemic stroke during the acute, subacute, and chronic stages. Motor function, balance, functional mobility, activities of daily living, and stroke-specific quality of life will be assessed at baseline, after the intervention, and at 3-month and 6-month follow-up.",[67,68,69],"Ischemic Stroke","Hemiplegia","Motor Function Impairment",[71,72,73,74,75,76],"Repetitive Transcranial Magnetic Stimulation","rTMS","Motor Recovery","Post-Stroke Hemiplegia","Neurorehabilitation","Motor function","NOT_YET_RECRUITING","2026-02-06",{"date":80,"type":81},"2026-02-10","ACTUAL",{"date":83,"type":61},"2026-02",{"date":85,"type":61},"2028-12",{"name":5,"class":6}]