[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636543":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":45,"centralContacts":49,"locations":58,"responsibleParty":79,"collaborators":36,"id":81,"slug":82,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":36,"eligibilityCriteria":87,"healthyVolunteers":88,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":36,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":102,"overallStatus":108,"whyStopped":36,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"Cook Children's Health Care System","OTHER",[8,16,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Group 1","EXPERIMENTAL","CP participants in the experiment intervention group 1 will receive rTMS using a figure-of-eight-shaped coil and rTMS stimulator (Nexstim, Finland) targeting the contralesional primary motor cortex. The intervention will consist of 10 sessions, each lasting 20 minutes, spread over four weeks. Each session will begin with priming: 10 minutes of 6-Hz rTMS at 90% of the resting motor threshold, delivered in two trains per minute (5 seconds per train with 25-second intervals between trains), totaling 600 priming pulses. This will be followed immediately by 10 minutes of 1-Hz rTMS at 90% of the resting motor threshold, delivered continuously without interruption, totaling 600 low-frequency pulses.",[13,14,15],"Device: MRI","Device: HD-EEG Recording","Device: rTMS",{"label":17,"type":10,"description":18,"interventionNames":19},"Intervention Group 2","CP Participants in experiment intervention group 2 will receive rTMS targeting the ipsilesional primary motor cortex. The intervention will consist of 10 sessions, each lasting 20 minutes, spread over four weeks. Each session will start with priming: 10 minutes of 6-Hz rTMS at 90% of the resting motor threshold, delivered in two trains per minute (5 seconds per train with 25-second intervals between trains), totaling 600 priming pulses. This will be followed immediately by 10 minutes of 10 Hz rTMS at 90% of the resting motor threshold, delivered continuously without interruption, totaling 2000 high-frequency pulses.",[13,14,15],{"label":21,"type":22,"description":23,"interventionNames":24},"Sham Group","SHAM_COMPARATOR","CP participants in the sham group will receive sham rTMS by positioning the coil perpendicular to the scalp without delivering active stimulation, targeting both the contralesional and ipsilesional primary motor cortex. The intervention will consist of 10 sessions, each lasting 20 minutes, spread over four weeks.",[13,14,15],{"label":26,"type":27,"description":28,"interventionNames":29},"Control Group","ACTIVE_COMPARATOR","Typically developed control group will complete a single baseline TMS-EEG session to measure TEPs. This involves high-density EEG recording during single-pulse TMS to assess cortical excitability. The session will last approximately 60-90 minutes.",[13,14],[31,37,41],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DEVICE","MRI","All participants will undergo an MRI scan prior to the intervention to acquire T1-weighted images. MRI data will be provided by the Cook Children's Radiology Department. MRI scans will be used for neuronavigation.",[26,9,17,21],null,{"type":32,"name":38,"description":39,"armGroupLabels":40,"otherNames":36},"HD-EEG Recording","High-density EEG (HD-EEG) is a safe and non-invasive brain imaging technique. It involves placing a cap with small sensors on the child's head to measure the brain's electrical activity. This technique does not send any energy into the brain. The investigators will use the HD-EEG to measure motor-evoked potentials (MEPs) and TMS-evoked potentials (TEPs).",[26,9,17,21],{"type":32,"name":42,"description":43,"armGroupLabels":44,"otherNames":36},"rTMS","rTMS is a safe, non-invasive way to map brain activity using gentle magnetic pulses. A small coil is placed near the head to stimulate nerve cells without any pain. This helps us understand how the brain controls movement.",[9,17,21],[46],{"name":47,"affiliation":5,"role":48},"Christos Papadelis, PhD","PRINCIPAL_INVESTIGATOR",[50,54],{"name":47,"role":51,"phone":52,"phoneExt":36,"email":53},"CONTACT","682-305-3236","Christos.Papadelis@cookchildrens.org",{"name":55,"role":51,"phone":56,"phoneExt":36,"email":57},"Behnam Ghabel Damirchi, MSc","682-367-3956","behnam.ghabeldamirchi@cookchildrens.org",[59],{"facility":60,"status":36,"city":61,"state":62,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":71,"contacts":72},"Cook Children's Hospital","Fort Worth","Texas","76107","United States","US",{"type":67,"coordinates":68},"Point",[69,70],-97.32085,32.72541,{"lat":70,"lon":69},[73,76],{"name":74,"role":51,"phone":52,"phoneExt":36,"email":75},"Dr. Christos Papadelis, PhD, PhD","Christos.Papadelis@cookchilrens.org",{"name":77,"role":78,"phone":36,"phoneExt":36,"email":36},"Behnam G Ghabel Damirchi, MSc","SUB_INVESTIGATOR",{"type":80,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR","100636543","repetitive-transcranial-magnetic-stimulation-on-motor-function-and-meta-plasticity-in-cerebral-palsy-tms-eeg-study-100636543",false,"NCT07567053","Repetitive Transcranial Magnetic Stimulation on Motor Function and Meta-Plasticity in Cerebral Palsy: TMS-EEG Study","6-Hz Primed Low and High-Frequency Repetitive Transcranial Magnetic Stimulation on Motor Function and Meta-Plasticity in Children With Cerebral Palsy: TMS-EEG Study","Inclusion Criteria (CP):\n\n* Aged 6 - 20 years,\n* A confirmed diagnosis of CP by a specialized professional (pediatric neurologist, PM\\&R physician, neonatal developmental specialist, or neonatologist) is a prerequisite for participation,\n* Classified as high functioning (Level I, II, or III) according to the Gross Motor Function Classification System (GMFCS),\n* Age-appropriate ability to understand and comply with study procedure throughout the entire duration of the study,\n* Preserved vision and hearing (with or without correction).\n\nInclusion Criteria (TD):\n\n* Aged 6 - 20 years\n* Age-appropriate ability to understand and comply with study procedure throughout the entire duration of the study,\n* Preserved vision and hearing (with or without correction).\n\nExclusion Criteria (CP):\n\n* Syndromic or genetic brain-related associations,\n* History of major trauma or brain surgery,\n* Inability to remain still,\n* History of Epilepsy,\n* Severe coexisting sickness or illness unrelated to CP or unstable medical conditions such as pneumonia,\n* Modified Ashworth Scale: Shoulder, elbow, and wrist scores more than 3,\n* Limb contractures caused by any other injury except CP,\n* Severe movement disorders that prevent intentional limb movements, such as choreoathetosis, or ballismus,\n* Contraindications for rTMS include non-removable metallic objects close to a coil and implanted electronic devices, such as cochlear implants and pacemakers.\n\nExclusion Criteria (TD):\n\n* Syndromic or genetic brain-related associations,\n* History of major trauma or brain surgery,\n* Inability to remain still,\n* History of Epilepsy,\n* Severe coexisting sickness or illness unrelated to CP or unstable medical conditions such as pneumonia,\n* Limb contractures caused by injury,\n* Severe movement disorders that prevent intentional limb movements, such as choreoathetosis, or ballismus,\n* Contraindications for rTMS include non-removable metallic objects close to a coil and implanted electronic devices, such as cochlear implants and pacemakers.",true,"ALL","6 Years","20 Years",{"count":93,"type":94},60,"ESTIMATED","INTERVENTIONAL",[97],"NA","This project examines the use of repetitive transcranial magnetic stimulation (rTMS) as a therapeutic approach to improve motor function in children with cerebral palsy (CP). By applying 6-Hz primed low and high-frequency rTMS and measuring brain responses through TMS-EEG, the study aims to enhance neural plasticity and motor recovery. The goal is to promote faster rehabilitation and reduce long-term healthcare needs.",[100,101],"Cerebral Palsy","Typically Developing Children",[100,103,104,105,106,42,107],"CP","TMS","repetitive Transcranial Magnetic Stimulation","Transcranial Magnetic Stimulation","TMS-EEG","NOT_YET_RECRUITING","2026-05-12",{"date":111,"type":112},"2026-05-14","ACTUAL",{"date":114,"type":94},"2026-05-01",{"date":116,"type":94},"2030-06-01",{"name":5,"class":6},1]