[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643752":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":26,"responsibleParty":47,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":10,"enrollmentInfo":58,"targetDuration":10,"studyType":61,"phases":10,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Istituto Clinico Humanitas","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Re-irradiation with proton",null,"treatment of recurrence of tumor with protontherapy",[13],{"name":14,"affiliation":15,"role":16},"Maria Ausilia Teriaca, MD, radiation oncologist","Humanitas Research Hospital IRCCS, Rozzano-Milan","PRINCIPAL_INVESTIGATOR",[18,22],{"name":14,"role":19,"phone":20,"phoneExt":10,"email":21},"CONTACT","+39 0282247461","maria.ausilia.teriaca@cancercenter.humanitas.it",{"name":23,"role":19,"phone":24,"phoneExt":10,"email":25},"Laura Bonavita, Master degree","+39 0282247026","laura.bonavita@humanitas.it",[27],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"IRCCS Humanitas Research Hospital","RECRUITING","Rozzano","Milano","20089","Italy","IT",{"type":36,"coordinates":37},"Point",[38,39],9.1559,45.38193,{"lat":39,"lon":38},[42,43],{"name":23,"role":19,"phone":24,"phoneExt":10,"email":25},{"name":44,"role":19,"phone":45,"phoneExt":10,"email":46},"Barbara Alt, nurse","+39 0282248513","barbara.alt@humanitas.it",{"type":48,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100643752","reproton-hn-prospective-observational-study-on-proton-re-irradiation-for-locoregional-recurrences-of-head-and-neck-tumors-100643752",false,"NCT07635641","REPROton-HN: Prospective Observational Study on Proton Re-irradiation for Locoregional Recurrences of Head and Neck Tumors","REPROton-HN","Inclusion Criteria:\n\n* ≥ 18 years old\n* ECOG 0-2\n* Pathologically and or radiologically confirmed head and neck cancer recurrence\n* Indication for proton therapy\n* Written informed consent for REPRO-HN according to applicable legal and ethical requirements by the end of radiotherapy treatment\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years old\n* ECOG\\>3\n* Life expectancy \\\u003C 3 months\n* Inability to provide informed consent","ALL","18 Years",{"count":59,"type":60},50,"ESTIMATED","OBSERVATIONAL","Some patients with head and neck cancer may develop a tumor recurrence in an area that has already been treated with radiotherapy. In these situations, surgery is not always possible, and giving radiotherapy again can be challenging because nearby healthy tissues and organs may already have received high radiation doses.\n\nThe REPROton-HN study is evaluating the use of proton therapy for these patients. Proton therapy is a type of radiation treatment that can deliver radiation more precisely to the tumor while reducing exposure to surrounding healthy tissues.\n\nThe aim of the study is to better understand how safe and effective proton therapy is when used as a second course of radiation treatment. Researchers will monitor side effects, tumor control, survival, and patients' quality of life. The results may help improve treatment planning and identify which patients are most likely to benefit from proton therapy in the future.",[64],"Head & Neck Cancer",[66,67,68,69,70,71],"head&neck cancer","re-irradiation","proton-therapy","protontherapy","radiotherapy","cancer","2026-06-03",{"date":74,"type":75},"2026-06-09","ACTUAL",{"date":77,"type":75},"2026-05-29",{"date":79,"type":60},"2036-05",{"name":5,"class":6},1]