[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633943":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":27,"centralContacts":36,"locations":43,"responsibleParty":60,"collaborators":27,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":71,"maxAge":27,"enrollmentInfo":72,"targetDuration":27,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":85,"whyStopped":27,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Centre hospitalier de l'Université de Montréal (CHUM)","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1. Conservative management group","ACTIVE_COMPARATOR","Participants first undergo standard proximal mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion. If a persistent distal medium-vessel occlusion remains after successful proximal recanalization, they are randomized to no additional distal endovascular intervention and continue with standard medical and post-procedural care.",[13,14],"Procedure: Proximal mechanical thrombectomy","Other: Conservative management",{"label":16,"type":17,"description":18,"interventionNames":19},"Arm 2. Rescue distal mechanical thrombectomy","EXPERIMENTAL","Participants first undergo standard proximal mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion. If a persistent distal medium-vessel occlusion remains after successful proximal recanalization, they are randomized to rescue distal mechanical thrombectomy during the same endovascular session.",[13,20],"Procedure: Rescue distal mechanical thrombectomy",[22,28,32],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"PROCEDURE","Proximal mechanical thrombectomy","Mechanical thrombectomy performed for the qualifying proximal large vessel occlusion before assessment of eligibility for randomization.",[9,16],null,{"type":23,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"Rescue distal mechanical thrombectomy","Rescue distal mechanical thrombectomy performed during the same endovascular session after successful proximal recanalization to treat persistent distal medium-vessel occlusion identified on angiography.",[16],{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":27},"Conservative management","No additional distal endovascular intervention after successful proximal mechanical thrombectomy. Participants continue with standard medical and post-procedural care.",[9],[37],{"name":38,"role":39,"phone":40,"phoneExt":41,"email":42},"Guylaine Gevry, BSc. Project manager","CONTACT","+1 514 890-8000","27235","neuroradiologie.recherche.chum@ssss.gouv.qc.ca",[44],{"facility":5,"status":27,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Montreal","Quebec","H2W 0C1","Canada","CA",{"type":51,"coordinates":52},"Point",[53,54],-73.58781,45.50884,{"lat":54,"lon":53},[57],{"name":58,"role":59,"phone":27,"phoneExt":27,"email":27},"Daniela E. Iancu Associate professor of Radiology, Neuroradiologist, MD","PRINCIPAL_INVESTIGATOR",{"type":61,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR","100633943","rescue-distal-thrombectomy-in-treatment-for-persistent-distal-occlusions-100633943",false,"NCT07533253","Rescue Distal Thrombectomy in Treatment for Persistent Distal Occlusions","Treatment of Persistent Distal Occlusion After Successful Proximal Recanalization in Thrombectomy - A PHASE II Trial","2BE3-PhaseII","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Acute ischemic stroke with proximal large vessel occlusion (M1, M2, ICA, or basilar artery) treatable with mechanical thrombectomy\n* Presence of one or more persistent distal occlusions (M2-M4, A1-A5, or P1-P5) after successful proximal mechanical thrombectomy\n* The participant is considered suitable for either rescue distal mechanical thrombectomy or conservative management in the event of persistent distal occlusion\n* Informed consent obtained from the participant or authorized representative, in accordance with the protocol and local regulations\n\nExclusion Criteria:\n\n* Poor expected 3-month prognosis due to comorbid conditions\n* Opposition by the participant or, in emergency inclusion circumstances, by an authorized representative","ALL","18 Years",{"count":73,"type":74},72,"ESTIMATED","INTERVENTIONAL",[77],"NA","The goal of this clinical trial is to determine whether rescue distal mechanical thrombectomy can improve outcomes in patients with persistent distal occlusions after successful proximal mechanical thrombectomy for acute ischemic stroke.\n\nMany patients with acute ischemic stroke caused by large vessel occlusion undergo emergency treatment with proximal mechanical thrombectomy, which removes the main clot and restores flow in a large artery. However, in some patients, one or more smaller distal arteries remain occluded after successful proximal recanalization. It is not yet known whether treating these persistent distal occlusions improves angiographic or clinical outcomes.\n\nThis study will compare two approaches:\n\nRescue distal mechanical thrombectomy: an additional distal mechanical thrombectomy procedure is performed during the same endovascular session.\n\nConservative management: no additional distal endovascular intervention is performed after successful proximal mechanical thrombectomy.\n\nThe main questions the study aims to answer are:\n\n* Is rescue distal mechanical thrombectomy feasible in this setting?\n* Is it safe?\n* Does it improve angiographic and clinical outcomes?\n\nParticipants will be randomly assigned during the index endovascular procedure to one of the two study groups and will be followed with imaging and clinical assessments during hospitalization and at 90 days.\n\nApproximately 72 participants will take part in this study at the Centre hospitalier de l'Université de Montréal (CHUM).",[80],"Acute Ischemic Stroke",[82,83,84],"thrombectomy","endovascular treatment","distal occlusion","NOT_YET_RECRUITING","2026-04-14",{"date":88,"type":89},"2026-04-16","ACTUAL",{"date":91,"type":74},"2026-09-01",{"date":93,"type":74},"2029-12-31",{"name":5,"class":6},1]