[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100554987":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":65,"centralContacts":69,"locations":78,"responsibleParty":95,"collaborators":32,"id":97,"slug":98,"hasResults":99,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":32,"eligibilityCriteria":103,"healthyVolunteers":104,"sex":105,"minAge":106,"maxAge":107,"enrollmentInfo":108,"targetDuration":32,"studyType":111,"phases":112,"briefSummary":114,"conditions":115,"keywords":32,"overallStatus":117,"whyStopped":32,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":127},{"fullName":5,"class":6},"The First Affiliated Hospital of Zhejiang Chinese Medical University","OTHER",[8,22],{"label":9,"type":10,"description":11,"interventionNames":12},"according to the order of their visits then were assigned numbers","EXPERIMENTAL","The patients were assigned numbers according to the order of their visits, and after obtaining informed consent, they were divided into a treatment group and a control group to conduct a prospective cohort study.",[13,14,15,16,17,18,19,20,21],"Behavioral: Low risk experimental group","Behavioral: Medium risk experimental group","Genetic: High risk experimental group","Behavioral: Control group COBB 10-20°","Behavioral: Control group COBB 20-45°","Behavioral: Control group COBB >45°","Other: Experimental group (AIS group)","Other: Control group (healthy control)","Other: Controlled follow-up before and after AIS",{"label":23,"type":10,"description":24,"interventionNames":25},"According to the order of their visits to the clinic, given the appropriate number,","According to the order of their visits to the clinic, given the appropriate number, divided into the test group and the control group, in strict accordance with the results of the group, the appropriate treatment and observation of the group, the teams of personnel and the implementation of clinical treatment should not be the same person.",[13,14,15,16,17,18,19,20,21],[27,33,37,42,46,50,54,58,61],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"BEHAVIORAL","Low risk experimental group","Guiding + Manipulation + Traditional Chinese Medicine",[23,9],null,{"type":28,"name":34,"description":35,"armGroupLabels":36,"otherNames":32},"Medium risk experimental group","Guiding + Manipulation + Traditional Chinese Medicine + Specific Exercise Therapy + Orthopedic Braces",[23,9],{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":32},"GENETIC","High risk experimental group","Guiding + Manipulation + Traditional Chinese Medicine + Specific Exercise Therapy + Orthopedic Braces + Specialized Inpatient Rehabilitation",[23,9],{"type":28,"name":43,"description":44,"armGroupLabels":45,"otherNames":32},"Control group COBB 10-20°","Specific Exercise Therapy",[23,9],{"type":28,"name":47,"description":48,"armGroupLabels":49,"otherNames":32},"Control group COBB 20-45°","Orthopedic Braces + Specific Exercise Therapy",[23,9],{"type":28,"name":51,"description":52,"armGroupLabels":53,"otherNames":32},"Control group COBB >45°","Orthopedic Braces + Specific Exercise Therapy + Recommended Surgery",[23,9],{"type":6,"name":55,"description":56,"armGroupLabels":57,"otherNames":32},"Experimental group (AIS group)","Molecular marker exploration and validation",[23,9],{"type":6,"name":59,"description":56,"armGroupLabels":60,"otherNames":32},"Control group (healthy control)",[23,9],{"type":6,"name":62,"description":63,"armGroupLabels":64,"otherNames":32},"Controlled follow-up before and after AIS","Construction and validation of AIS risk prediction model completed",[23,9],[66],{"name":67,"affiliation":5,"role":68},"Jiang Zhong, bachelor","STUDY_DIRECTOR",[70,74],{"name":67,"role":71,"phone":72,"phoneExt":32,"email":73},"CONTACT","13588887567","pjjzh@163.com",{"name":75,"role":71,"phone":76,"phoneExt":32,"email":77},"Honggen Du, bachelor","13958088996","duhonggen1212@163.com",[79],{"facility":80,"status":32,"city":81,"state":82,"zip":83,"country":84,"countryCode":85,"cosmosGeoPoint":86,"geoPoint":91,"contacts":92},"Prokin balance apparatus","Hangzhou","Zhejiang","310006","China","CN",{"type":87,"coordinates":88},"Point",[89,90],120.16142,30.29365,{"lat":90,"lon":89},[93],{"name":94,"role":71,"phone":32,"phoneExt":32,"email":32},"Jingying Liang, master candidate",{"type":96,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR","100554987","research-on-key-technologies-for-risk-prediction-and-precise-diagnosis-and-treatment-of-ais-based-on-epigene-phenotype-100554987",false,"NCT06506227","Research on Key Technologies for Risk Prediction and Precise Diagnosis and Treatment of AIS Based on Epigene-phenotype","Research on Key Technologies for Risk Prediction and Precise Diagnosis and Treatment of Adolescent Idiopathic Scoliosis Based on Epigene-phenotype","Inclusion Criteria:\n\n* Patients diagnosed with AIS;② Sex is not limited, age 10-18 years old; ③ Those who sign the informed consent and can cooperate with follow-up visits; ④ Those who can cooperate with X-ray, chemical test, genetic test and other examination and evaluation for the measurement of relevant indexes.\n\nExclusion Criteria:\n\n* Subjects with spine-related diseases such as Marfan's syndrome;\n\n  * Subjects with previous ankylosing spondylitis, spinal neurofibroma, spinal tuberculosis, spinal trauma and other spine-related diseases;\n\n    * Subjects with combined serious medical diseases and psychiatric patients;\n\n      * Those with ECOG score \\> 2, which may have an impact on the study results;\n\n        * Those who are affected by external factors such as economy, individualized differences, etc., so that they cannot complete the study.",true,"ALL","10 Years","18 Years",{"count":109,"type":110},2000,"ESTIMATED","INTERVENTIONAL",[113],"NA","Mining AIS biomarkers, elucidating the new mechanism of AIS pathogenicity, constructing risk prediction models, optimizing AIS precise diagnosis and treatment techniques, formulating precise diagnosis and treatment protocols and technical specifications for AIS combined with Chinese and Western medicine with independent intellectual property rights, and realizing the full coverage of Zhejiang Province by the end of 2026, so as to form the \"Zhejiang experience\" of AIS diagnosis and treatment.",[116],"Adolescent Idiopathic Scoliosis","NOT_YET_RECRUITING","2024-07-16",{"date":120,"type":121},"2024-07-17","ACTUAL",{"date":123,"type":110},"2024-09-01",{"date":125,"type":110},"2026-12-31",{"name":5,"class":6},1]