[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602801":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":20,"responsibleParty":27,"collaborators":20,"id":31,"slug":32,"hasResults":33,"nctId":34,"briefTitle":35,"officialTitle":35,"acronym":20,"eligibilityCriteria":36,"healthyVolunteers":37,"sex":38,"minAge":39,"maxAge":40,"enrollmentInfo":41,"targetDuration":20,"studyType":44,"phases":45,"briefSummary":47,"conditions":48,"keywords":20,"overallStatus":50,"whyStopped":20,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":20},{"fullName":5,"class":6},"Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Diet and Exercise intervention","EXPERIMENTAL","Diet intervention：Provide a fixed amount of food every day Exercise intervention：Train every day according to a specific course schedule",[13],"Behavioral: lifestyle intervention",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","lifestyle intervention","This study implemented lifestyle interventions including dietary and exercise interventions. Based on the assessment of the physical condition of the volunteers, a personalized training plan is formulated and a standardized diet is provided. The entire intervention process lasts for 8 weeks.",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"John R Speakman, Doctor","CONTACT","15810868669","j.speakman@abdn.ac.uk",{"type":28,"investigatorFullName":29,"investigatorTitle":30,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","John R. Speakman","Professor","100602801","research-on-metabolic-adaptation-in-obese-people-100602801",false,"NCT07128238","Research on \"Metabolic Adaptation\" in Obese People","Inclusion Criteria:\n\n* BMI： ≥30kg\u002Fm2 Willing to participate in an 8-week weight-loss camp program\n\nExclusion Criteria:\n\n* Metabolic or cardiovascular diseases (such as diabetes) Mental disorders (such as depression and claustrophobia) Infectious diseases (such as AIDS, tuberculosis, malaria) High blood pressure Pregnant, lactating, or prepare for pregnancy Implanted or portable electro-mechanical device Taking antihypertensive or weight-loss medications",true,"FEMALE","18 Years","40 Years",{"count":42,"type":43},10,"ESTIMATED","INTERVENTIONAL",[46],"NA","Obesity has become a global public health crisis, with 810 million adults classified as obese (BMI ≥ 30 kg\u002Fm²) worldwide in 2020. This number is projected to rise to 1.53 billion by 2035. China faces a particularly severe challenge, with one of the highest rates and fastest growth in obesity prevalence globally. Obesity is a well-established risk factor for numerous chronic diseases, including cancer, cardiovascular disease, and diabetes. As such, weight loss is essential for improving health outcomes and preventing related complications.\n\nLifestyle interventions-primarily dietary modifications and physical activity-are the cornerstone of obesity treatment, aiming to reduce weight by addressing energy intake and expenditure. Accumulating evidence indicates that energy imbalance is a key driver of obesity. However, resting metabolic rate (RMR), which accounts for approximately 60-75% of total energy expenditure, often declines during lifestyle interventions due to metabolic adaptation. This adaptive decrease in RMR can undermine weight loss efforts.\n\nWhile both body composition and core body temperature are known to influence RMR, their specific roles in metabolic adaptation during lifestyle interventions remain poorly understood. This study aims to investigate the individual contributions of changes in body composition and fluctuations in core body temperature to the observed reduction in RMR during such interventions. By combining body composition analysis and continuous core temperature monitoring, the study seeks to uncover mechanisms underlying metabolic adaptation and identify potential targets for enhancing weight loss strategies.",[49],"Body Temperature Changes","NOT_YET_RECRUITING","2026-01-19",{"date":53,"type":54},"2026-01-22","ACTUAL",{"date":56,"type":43},"2026-01-28",{"date":58,"type":43},"2027-12-31",{"name":5,"class":6}]