[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588923":3},{"organization":4,"armGroups":7,"interventions":50,"overallOfficials":56,"centralContacts":61,"locations":70,"responsibleParty":89,"collaborators":10,"id":91,"slug":92,"hasResults":93,"nctId":94,"briefTitle":95,"officialTitle":95,"acronym":10,"eligibilityCriteria":96,"healthyVolunteers":93,"sex":97,"minAge":98,"maxAge":10,"enrollmentInfo":99,"targetDuration":10,"studyType":102,"phases":10,"briefSummary":103,"conditions":104,"keywords":107,"overallStatus":112,"whyStopped":10,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},{"fullName":5,"class":6},"Xuanwu Hospital, Beijing","OTHER",[8,14,18,22,26,30,34,38,42,46],{"label":9,"type":10,"description":11,"interventionNames":12},"Mild stenosis group without collateral circulation",null,"There is no anterior communicating artery, posterior communicating artery, or internal external carotid artery in the skull, and the degree of stenosis in the V4 segment of the middle cerebral artery or vertebral artery is less than 50%",[13],"Procedure: stenting",{"label":15,"type":10,"description":16,"interventionNames":17},"Group without collateral circulation and stenosis","There is no anterior communicating artery, posterior communicating artery, or internal carotid external artery in the skull, and there is no stenosis in the V4 segment of the affected middle cerebral artery or vertebral artery.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Moderate stenosis group without collateral circulation","There is no anterior communicating artery, posterior communicating artery, or internal carotid external artery in the skull, and the degree of stenosis in the V4 segment of the affected middle cerebral artery or vertebral artery is 50-69%.",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Severe stenosis group without collateral circulation","There is no anterior communicating artery, posterior communicating artery, or internal carotid external artery in the skull, and the degree of stenosis in the V4 segment of the affected middle cerebral artery or vertebral artery is 70-99%.",[13],{"label":27,"type":10,"description":28,"interventionNames":29},"Group with collateral circulation and no stenosis","There are anterior or posterior communicating arteries or internal external carotid arteries in the skull, and there is no stenosis in the V4 segment of the affected middle cerebral artery or vertebral artery.",[13],{"label":31,"type":10,"description":32,"interventionNames":33},"Mild stenosis of collateral circulation group","There are anterior or posterior communicating arteries or internal external carotid arteries in the skull, and the degree of stenosis in the V4 segment of the affected middle cerebral artery or vertebral artery is less than 50%.",[13],{"label":35,"type":10,"description":36,"interventionNames":37},"Moderate stenosis of collateral circulation group","There are anterior or posterior communicating arteries or internal external carotid arteries in the skull, and the degree of stenosis in the V4 segment of the affected middle cerebral artery or vertebral artery is 50-69%.",[13],{"label":39,"type":10,"description":40,"interventionNames":41},"Group with severe stenosis of collateral circulation","There are anterior or posterior communicating arteries or internal external carotid arteries in the skull, and the degree of stenosis in the V4 segment of the affected middle cerebral artery or vertebral artery is 70-99%.",[13],{"label":43,"type":10,"description":44,"interventionNames":45},"End event group","During the 1-year follow-up after surgery, the patient experienced new stroke events such as ischemic stroke, transient ischemic attack, and hemorrhagic stroke.",[13],{"label":47,"type":10,"description":48,"interventionNames":49},"Group without endpoint events","At the 1-year follow-up after surgery, the patient did not experience any new stroke events such as ischemic stroke, transient ischemic attack, or hemorrhagic stroke.",[13],[51],{"type":52,"name":53,"description":54,"armGroupLabels":55,"otherNames":10},"PROCEDURE","stenting","All individuals are anesthetized, with local or general anesthesia depending on the patient's level of cooperation. During the surgery, heparin must be injected intravenously to control the activated clotting time between 250-300 seconds. The surgery is performed via the femoral artery, and the choice of stent type and size, as well as any required equipment, are determined by the intervention personnel themselves.",[43,27,39,15,47,9,31,19,35,23],[57],{"name":58,"affiliation":59,"role":60},"Yingqi Xing","Vascular Ultrasound Diagnosis Department, Xuanwu Hospital","PRINCIPAL_INVESTIGATOR",[62,66],{"name":58,"role":63,"phone":64,"phoneExt":10,"email":65},"CONTACT","+8618610047846","xingyq2009@sina.com",{"name":67,"role":63,"phone":68,"phoneExt":10,"email":69},"Songwei Chen","+8615896921765","csw1021@sina.cn",[71],{"facility":72,"status":10,"city":73,"state":74,"zip":75,"country":76,"countryCode":77,"cosmosGeoPoint":78,"geoPoint":83,"contacts":84},"Department of Vascular Ultrasound, Xuanwu Hospital, Capital Medical University","Beijing","Beijing Municipality","100053","China","CN",{"type":79,"coordinates":80},"Point",[81,82],116.39723,39.9075,{"lat":82,"lon":81},[85,87],{"name":86,"role":63,"phone":64,"phoneExt":10,"email":65},"Ying-qi Xing",{"name":88,"role":63,"phone":68,"phoneExt":10,"email":69},"Song-wei Chen",{"type":90,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100588923","research-on-ultrasound-diagnostic-criteria-for-intracranial-and-extracranial-arterial-serial-stenosis-100588923",false,"NCT06947720","Research on Ultrasound Diagnostic Criteria for Intracranial and Extracranial Arterial Serial Stenosis","Inclusion Criteria:\n\n1. Patients diagnosed by carotid ultrasound with severe stenosis of the extracranial segment of the internal carotid artery or severe stenosis of the initial segment of the unilateral vertebral artery;\n2. Perform stent placement surgery within 2 weeks of ultrasound examination, and perform DSA and CTA examinations;\n3. Age ≥ 18 years old;\n4. Clinical data is complete.\n\nExclusion Criteria:\n\n1. Bilateral temporal windows are not transparent to sound;\n2. Patients with severe stenosis of the extracranial segment of the internal carotid artery have ipsilateral MCA occlusion\u002Fipsilateral common carotid artery severe stenosis or occlusion;\n3. Patients with severe stenosis of the extracranial segment of the internal carotid artery have severe stenosis of the contralateral carotid artery;\n4. Patients with severe stenosis or occlusion of the anterior circulation in the initial segment of unilateral vertebral artery;\n5. Severe stenosis or occlusion of bilateral subclavian arteries;\n6. Vasospasm caused by subarachnoid hemorrhage, etc;\n7. Related MCA or vertebral artery thrombolysis or endovascular treatment;\n8. Arrhythmias such as atrial fibrillation or heart failure that affect velocity measurement;\n9. CT, MRI, DSA examination contraindications or refusal of examination;\n10. Severe bleeding disorders or coagulation dysfunction;\n11. Merge serious diseases of other organs or tissues.","ALL","18 Years",{"count":100,"type":101},700,"ESTIMATED","OBSERVATIONAL","This study utilized different hemodynamic parameters of transcranial color-coded Doppler (TCCD) and transcranial Doppler (TCD) to conduct ultrasonic grading evaluation on middle cerebral artery (MCA) stenosis severity in patients with severe extracranial internal carotid artery stenosis, as well as intracranial V4 segment stenosis severity in patients with severe vertebral artery (VA) origin stenosis. The aim was to establish ultrasonic diagnostic criteria and provide reference basis for clinical treatment decision-making. Clarify the distribution of stroke risk factors, establish and evaluate stroke risk identification and prediction models. Patient cohort: Individuals undergoing carotid artery stenting or vertebral artery stenting, including those with either 1) severe extracranial internal carotid artery stenosis combined with ipsilateral MCA tandem stenosis, or 2) unilateral severe vertebral artery origin stenosis combined with intracranial V4 segment tandem stenosis. Collected data included demographic information, vascular ultrasound findings, and imaging examination results. All patients underwent a 1-year follow-up investigation documenting follow-up vascular ultrasound results, laboratory test results, imaging findings, clinical symptoms (ischemic stroke, transient ischemic attack, hemorrhagic stroke), and occurrence of endpoint events.",[105,106],"Ischemic Stroke","Carotid Stenosis",[108,109,110,111],"Serial stenosis","hemodynamics","Ultrasound diagnostic criteria","prediction model","NOT_YET_RECRUITING","2025-08-11",{"date":115,"type":116},"2025-08-15","ACTUAL",{"date":118,"type":101},"2025-09-01",{"date":120,"type":101},"2027-06-30",{"name":5,"class":6},1]