[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589437":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":39,"responsibleParty":63,"collaborators":65,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":25,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":25,"enrollmentInfo":78,"targetDuration":25,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":55,"whyStopped":25,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Johns Hopkins University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Stress-First Sequence","EXPERIMENTAL","Participants in this arm will first undergo the stress condition using the Maastricht Acute Stress Test (MAST) and then complete the non-stress condition (NST) in a subsequent session.",[13,14],"Behavioral: Acute Stress Intervention (MAST-based)","Behavioral: Non-Stress Intervention (NST-based)",{"label":16,"type":10,"description":17,"interventionNames":18},"Non-Stress-First Sequence","Participants in this arm will first complete the non-stress condition (NST) and then undergo the stress condition using the Maastricht Acute Stress Test (MAST) in a subsequent session.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Acute Stress Intervention (MAST-based)","This intervention uses the Maastricht Acute Stress Test (MAST) to induce an acute stress response. Participants are exposed to standardized stress tasks while performing laboratory-based assessments of cognitive, emotional, and control aspects of resilience.",[16,9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Non-Stress Intervention (NST-based)","In this control intervention, participants complete the same battery of laboratory tasks without exposure to the acute stressor.",[16,9],[31],{"name":32,"affiliation":5,"role":33},"Suky Martinez, PhD","PRINCIPAL_INVESTIGATOR",[35],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","410-550-0007","smart209@jh.edu",[40,54],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":25},"Johns Hopkins University Bayview Medical Campus","NOT_YET_RECRUITING","Baltimore","Maryland","21224","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-76.61219,39.29038,{"lat":52,"lon":51},{"facility":41,"status":55,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":56,"geoPoint":58,"contacts":59},"RECRUITING",{"type":49,"coordinates":57},[51,52],{"lat":52,"lon":51},[60],{"name":61,"role":36,"phone":62,"phoneExt":25,"email":38},"Alec Zhang, BS","410-550-4121",{"type":64,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[66],{"name":67,"class":68},"National Institute on Drug Abuse (NIDA)","NIH","100589437","resilience-among-individuals-with-opioid-use-disorder-100589437",false,"NCT06954402","Resilience Among Individuals With Opioid Use Disorder","A Novel Human Laboratory Model of Resilience Among Individuals With Opioid Use Disorder","Inclusion Criteria:\n\n1. Can provide informed consent and can comply with study procedures\n2. Adults aged ≥18 years\n3. Meet Diagnostic and Statistical Manual (DSM-5) criteria for current opioid use disorder or are currently receiving pharmacotherapy for the treatment of OUD (e.g. methadone or buprenorphine maintenance treatment \\[remission\\])\n4. Urine sample that tests positive for opioids\n5. Test negative for pregnancy at screening (females only)\n\nExclusion Criteria:\n\n1. Being pregnant or breastfeeding\n2. Significant mental health or physical disorder, or life circumstances, that is judged by the investigators to interfere with study participation","ALL","18 Years",{"count":79,"type":80},125,"ESTIMATED","INTERVENTIONAL",[83],"NA","The goal of this clinical trial is to develop a human laboratory model of resilience in people with opioid use disorder (OUD). The investigators aim to learn if objective tasks that measure cognitive, emotional, and control aspects of resilience match up with self-reported resilience during stress and non-stress situations.",[86],"Opioid Use Disorder",[88,89,90],"opioids","opioid use disorder","stress","2026-06-22",{"date":93,"type":94},"2026-06-23","ACTUAL",{"date":96,"type":94},"2026-05-29",{"date":98,"type":80},"2029-04-30",{"name":5,"class":6},2]