[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624481":3},{"organization":4,"armGroups":7,"interventions":40,"overallOfficials":46,"centralContacts":67,"locations":77,"responsibleParty":92,"collaborators":96,"id":99,"slug":100,"hasResults":101,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":46,"eligibilityCriteria":105,"healthyVolunteers":106,"sex":107,"minAge":108,"maxAge":109,"enrollmentInfo":110,"targetDuration":46,"studyType":113,"phases":114,"briefSummary":116,"conditions":117,"keywords":122,"overallStatus":129,"whyStopped":46,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":139},{"fullName":5,"class":6},"Istanbul University - Cerrahpasa","OTHER",[8,14,20,25,30,35],{"label":9,"type":10,"description":11,"interventionNames":12},"Strategy 1: Constant Daily Dose - Caffeine First","EXPERIMENTAL","Participants receive caffeine at a constant daily dose of 3 mg\u002Fkg\u002Fday for the first 4-week intervention period, followed by a 2-week washout, then cross over to placebo for the second 4-week period. Supervised resistance training is performed 3 times per week throughout both periods.",[13],"Dietary Supplement: Caffeine (Constant Daily Dose)",{"label":15,"type":16,"description":17,"interventionNames":18},"Strategy 1: Constant Daily Dose - Placebo First","PLACEBO_COMPARATOR","Participants receive placebo for the first 4-week intervention period, followed by a 2-week washout, then cross over to caffeine at a constant daily dose of 3 mg\u002Fkg\u002Fday for the second 4-week period. Supervised resistance training is performed 3 times per week throughout both periods.",[19],"Dietary Supplement: Placebo (Constant Daily Dose)",{"label":21,"type":10,"description":22,"interventionNames":23},"Strategy 2: Escalating Dose - Caffeine First","Participants receive caffeine with a gradually escalating dose starting at 3 mg\u002Fkg\u002Fday in week 1 and increasing to 6 mg\u002Fkg\u002Fday by week 4, followed by a 2-week washout, then cross over to placebo for the second 4-week period. Supervised resistance training is performed 3 times per week throughout both periods.",[24],"Dietary Supplement: Caffeine (Escalating Dose)",{"label":26,"type":16,"description":27,"interventionNames":28},"Strategy 2: Escalating Dose - Placebo First","Participants receive placebo for the first 4-week intervention period, followed by a 2-week washout, then cross over to caffeine with a gradually escalating dose (3 to 6 mg\u002Fkg\u002Fday) for the second 4-week period. Supervised resistance training is performed 3 times per week throughout both periods.",[29],"Dietary Supplement: Placebo (Escalating Dose)",{"label":31,"type":10,"description":32,"interventionNames":33},"Strategy 3: Training Days Only - Caffeine First","Participants receive caffeine at 3 mg\u002Fkg only on training days (3 times per week) for the first 4-week intervention period, followed by a 2-week washout, then cross over to placebo for the second 4-week period. Supervised resistance training is performed 3 times per week throughout both periods.",[34],"Dietary Supplement: Caffeine (Training Days Only)",{"label":36,"type":16,"description":37,"interventionNames":38},"Strategy 3: Training Days Only - Placebo First","Participants receive placebo only on training days (3 times per week) for the first 4-week intervention period, followed by a 2-week washout, then cross over to caffeine at 3 mg\u002Fkg for the second 4-week period. Supervised resistance training is performed 3 times per week throughout both periods.",[39],"Dietary Supplement: Placebo (Training Days Only)",[41,47,51,55,59,63],{"type":42,"name":43,"description":44,"armGroupLabels":45,"otherNames":46},"DIETARY_SUPPLEMENT","Caffeine (Constant Daily Dose)","Oral caffeine capsule at 3 mg\u002Fkg body weight, consumed daily approximately 60 minutes before training sessions (on training days) or at the same time of day (on rest days).",[9],null,{"type":42,"name":48,"description":49,"armGroupLabels":50,"otherNames":46},"Placebo (Constant Daily Dose)","Identical-appearing placebo capsule consumed at the same times as the caffeine intervention.",[15],{"type":42,"name":52,"description":53,"armGroupLabels":54,"otherNames":46},"Caffeine (Escalating Dose)","Oral caffeine starting at 3 mg\u002Fkg\u002Fday and increasing incrementally to reach 6 mg\u002Fkg\u002Fday by week 4.",[21],{"type":42,"name":56,"description":57,"armGroupLabels":58,"otherNames":46},"Placebo (Escalating Dose)","Placebo capsule daily for 4 weeks with simulated dose escalation protocol, then crossover to escalating caffeine after 2-week washout.",[26],{"type":42,"name":60,"description":61,"armGroupLabels":62,"otherNames":46},"Caffeine (Training Days Only)","Oral caffeine capsule at 3 mg\u002Fkg body weight, consumed only on training days approximately 60 minutes before exercise.",[31],{"type":42,"name":64,"description":65,"armGroupLabels":66,"otherNames":46},"Placebo (Training Days Only)","Placebo capsule only on training days for 4 weeks, then crossover to caffeine after 2-week washout.",[36],[68,73],{"name":69,"role":70,"phone":71,"phoneExt":46,"email":72},"Abdullah Demirli, PhD","CONTACT","+90 545 259 22 25","abdullah.demirli@iuc.edu.tr",{"name":74,"role":70,"phone":75,"phoneExt":46,"email":76},"Kaan Kaya, PhD","+90 546 876 0049","kaan.kaya@yeniyuzyil.edu.tr",[78],{"facility":79,"status":46,"city":80,"state":81,"zip":82,"country":83,"countryCode":46,"cosmosGeoPoint":84,"geoPoint":89,"contacts":90},"Istanbul University-Cerrahpasa, Faculty of Sport Sciences Performance Laboratory","Istanbul","Avcilar","34010","Turkey (Türkiye)",{"type":85,"coordinates":86},"Point",[87,88],28.94966,41.01384,{"lat":88,"lon":87},[91],{"name":69,"role":70,"phone":71,"phoneExt":46,"email":72},{"type":93,"investigatorFullName":94,"investigatorTitle":95,"investigatorAffiliation":5,"oldNameTitle":46,"oldOrganization":46},"PRINCIPAL_INVESTIGATOR","Abdullah Demirli","Assistant Professor",[97],{"name":98,"class":6},"İstanbul Yeni Yüzyıl Üniversitesi","100624481","resistance-training-adaptations-and-caffeine-intake-100624481",false,"NCT07410195","Resistance Training Adaptations and Caffeine Intake","Study of Different Caffeine Supplementation Strategies on Resistance Training-Induced Adaptations","Inclusion Criteria:\n\n* Male sex and age between 18-30 years\n* No history of caffeine use or very low habitual intake (\\\u003C50 mg\u002Fday)\n* No participation in a regular resistance training program in the past 6 months\n* Body mass index (BMI) between 18.5-30 kg\u002Fm2\n* Willingness to attend all training and testing sessions regularly\n* Provision of written informed consent after being fully informed about the study\n\nExclusion Criteria:\n\n* Presence of cardiovascular, metabolic, renal, hepatic, or other serious chronic diseases\n* Diagnosed psychiatric disorders or severe caffeine intolerance\u002Fallergy\n* Use of medications affecting caffeine metabolism or muscle anabolism (e.g., beta-blockers, antidepressants, anabolic steroids)\n* Musculoskeletal injuries that prevent safe resistance training\n* Smoking or alcohol consumption at levels that could affect study outcomes\n* Concurrent participation in another exercise intervention study\n* Inability to tolerate DXA scanning, blood sampling, or D2O ingestion procedures",true,"MALE","18 Years","30 Years",{"count":111,"type":112},180,"ESTIMATED","INTERVENTIONAL",[115],"NA","This randomized, double-blind, placebo-controlled crossover trial investigates the effects of three different caffeine supplementation strategies on resistance training-induced adaptations in 180 caffeine-naive, inactive young adult males. Participants will undergo two 4-week supervised resistance training programs separated by a 2-week washout\u002Fcrossover period. The three caffeine strategies are: (1) constant daily low-moderate dosing (3 mg\u002Fkg\u002Fday), (2) gradually escalating dose (3 to 6 mg\u002Fkg across weeks), and (3) training-day-only caffeine (3 mg\u002Fkg\u002Fday). Primary outcomes include non-invasive measures of integrated anabolism and hypertrophy (D2O-derived plasma proteomic fractional synthesis rate, DXA muscle volume) and strength metrics. Secondary outcomes include hormonal responses (insulin, cortisol, testosterone, IGF-1), sleep\u002Frecovery parameters, and adverse effects.",[118,119,120,121],"Muscle Hypotrophy","Exercise Performance","Muscle Strength","Adaptation",[123,124,125,126,127,128],"Caffeine","Resistance Training","Muscle Adaptation","Supplementation","Strength Training","Hypertrophy","NOT_YET_RECRUITING","2026-02-07",{"date":132,"type":133},"2026-02-13","ACTUAL",{"date":135,"type":112},"2026-02-20",{"date":137,"type":112},"2026-04-20",{"name":5,"class":6},1]