[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100443196":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":27,"locations":37,"responsibleParty":56,"collaborators":58,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":19,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":86,"overallStatus":40,"whyStopped":19,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Respiratory muscle impairment","EXPERIMENTAL","Minor patients with primary or secondary impairment of respiratory muscles and followed at Necker Hospital",[13],"Other: Esogastric pressure measurement",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Esogastric pressure measurement","Measurement of work of breathing and respiratory muscles strength using an esogastric catheter.\n\nOne measurement or before and after (6 months and 1 year) the initiation of a pharmacological treatment in order to assess the effect of the treatment on respiratory muscle function.",[9],null,[21,24],{"name":22,"affiliation":5,"role":23},"Brigitte FAUROUX, MD, PhD","PRINCIPAL_INVESTIGATOR",{"name":25,"affiliation":5,"role":26},"Sonia KHIRANI, PhD","STUDY_DIRECTOR",[28,33],{"name":22,"role":29,"phone":30,"phoneExt":31,"email":32},"CONTACT","1 71 19 60 92","+33","brigitte.fauroux@aphp.fr",{"name":34,"role":29,"phone":35,"phoneExt":31,"email":36},"Hélène MOREL","1 71 19 63 46","helene.morel@aphp.fr",[38],{"facility":39,"status":40,"city":41,"state":19,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Hôpital Necker-Enfants Malades","RECRUITING","Paris","75015","France","FR",{"type":46,"coordinates":47},"Point",[48,49],2.3488,48.85341,{"lat":49,"lon":48},[52,53],{"name":22,"role":29,"phone":30,"phoneExt":31,"email":32},{"name":54,"role":55,"phone":19,"phoneExt":19,"email":19},"Lucie GRIFFON, MD","SUB_INVESTIGATOR",{"type":57,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR",[59],{"name":60,"class":6},"URC-CIC Paris Descartes Necker Cochin","100443196","respiratory-muscles-and-work-of-breathing-in-children-100443196",false,"NCT05051254","Respiratory Muscles and Work of Breathing in Children","WOB&MR_Ped","Inclusion Criteria:\n\n* Patients aged less than 18 years old with primary or secondary impairment of respiratory muscles and followed at Necker Hospital\n* Patients under spontaneous breathing or noninvasive or invasive mechanical ventilation\n* Written informed consent\n\nExclusion Criteria:\n\n* No social insurance\n* Significant psychomotor retardation\n* Absence of cooperation\n* Significant agitation\n* Hemodynamic instability\n* Acute condition or temporary drug treatments that may interfere with the results of the respiratory muscle explorations","ALL","0 Years","17 Years",{"count":72,"type":73},550,"ESTIMATED","INTERVENTIONAL",[76],"NA","Respiratory muscle testing allows a quantitative assessment of inspiratory and expiratory muscles in children of any age with primary or secondary respiratory muscle impairment, in order to better understand the pathophysiology of respiratory impairment and guide therapeutic management. The use of an invasive technique (esogastric probe) makes it possible to specifically explore the diaphragm, the accessory inspiratory muscles and the expiratory muscles in order to detect dysfunction or paralysis of these muscles, and to estimate the work of breathing in order to better guide the respiratory management.\n\nThe primary objective of the study is to evaluate the respiratory effort in children with primary or secondary impairment of the respiratory muscles during spontaneous breathing or during mechanical ventilation.",[79,80,81,82,83,84,85],"Neuromuscular Diseases","Congenital Diaphragmatic Hernia","Lung Diseases","Cardiac Diseases","Scoliosis","Diaphragmatic Impairment","Respiratory Muscle Impairment",[87,88,89,90,91,92],"Respiratory muscle testing","Respiratory muscle strength","Work of breathing","Esogastric pressures","Diaphragmatic dysfunction","Diaphragmatic paralysis","2026-03-30",{"date":95,"type":96},"2026-04-03","ACTUAL",{"date":98,"type":96},"2022-01-19",{"date":100,"type":73},"2028-01",{"name":5,"class":6},1]