[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100530698":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":38,"responsibleParty":58,"collaborators":25,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":25,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":25,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":40,"whyStopped":25,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Vanderbilt University Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active respiratory muscle strength training","EXPERIMENTAL","Enrolled heart transplant patients will undergo active preoperative respiratory strength training using two respiratory strength training devices from enrollment until they receive a heart transplant.",[13],"Behavioral: Active respiratory muscle strength training",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham respiratory muscle strength training","SHAM_COMPARATOR","Enrolled heart transplant patients will undergo sham preoperative respiratory strength training using two respiratory strength training devices from enrollment until they receive a heart transplant. For individuals completing sham respiratory strength training, the spring will be removed from the devices as has been done in prior sham-controlled trials.",[19],"Behavioral: Sham respiratory muscle strength training",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Devices will be set to 60% of participants' maximum expiratory pressure and maximum inspiratory pressure. Participants will complete training 7 days per week by performing 5 sets of 5 repetitions for both expiratory and inspiratory muscle strength training (a total of 50 repetitions).",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Springs will be removed from devices to ensure training is done without resistance. Participants will complete training 7 days per week by performing 5 sets of 5 repetitions for both expiratory and inspiratory sham muscle strength training (a total of 50 repetitions).",[15],[30],{"name":31,"affiliation":5,"role":32},"Cara Donohue, Ph.D.","PRINCIPAL_INVESTIGATOR",[34],{"name":31,"role":35,"phone":36,"phoneExt":25,"email":37},"CONTACT","615-852-5085","cara.donohue@vumc.org",[39],{"facility":5,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Nashville","Tennessee","37232","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-86.78444,36.16589,{"lat":50,"lon":49},[53,55],{"name":54,"role":35,"phone":36,"phoneExt":25,"email":37},"Cara Donohue",{"name":56,"role":35,"phone":36,"phoneExt":25,"email":57},"Jill Cable","irad.lab@vumc.org",{"type":32,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Cara Donohue, Ph.D. CCC-SLP","Assistant Professor, Director of Medical Speech-Language Pathology","100530698","respiratory-strength-training-in-heart-transplant-recipients-100530698",false,"NCT06190171","Respiratory Strength Training in Heart Transplant Recipients","Impact of Preoperative Respiratory Strength Training on Postoperative Health for Heart Transplant Recipients","Inclusion Criteria:\n\n1. Adult (18-90 years old)\n2. Not pregnant\n3. Undergoing evaluation or actively waitlisted for heart transplantation at VUMC with a waitlist status of 1-6\n4. Have a computer, tablet or electronic device with a stable internet connection for telehealth sessions (outpatient)\n5. Be willing to undergo testing procedures and complete the exercise training program.\n\nExclusion Criteria:\n\n1. Individual \\\u003C18 years old, \\>90 years old\n2. Pregnant\n3. No access to a computer, tablet or electronic device with a stable internet connection for telehealth sessions\n4. Unwilling or unable to undergo testing procedures and complete the exercise training program.","ALL","18 Years","90 Years",{"count":72,"type":73},90,"ESTIMATED","INTERVENTIONAL",[76],"NA","This research study is investigating whether completing breathing exercises before surgery helps heart transplant patients recover after surgery. Previous studies have shown that breathing exercises can improve breathing, cough, and swallow function in patients with other diseases\u002Fconditions. The current study will investigate the impact of a preoperative respiratory muscle strength training program on breathing and cough function, swallow function, patient-reported eating and swallowing fatigue, and health outcomes in individuals undergoing heart transplantation.\n\nParticipants will:\n\n* undergo tests of breathing, cough, and swallow function\n* complete questionnaires about the treatment, their swallow function\n* complete breathing exercises daily",[79,80],"Dysphagia","Heart Transplant Recipients",[82,83,84,85,86,87,88,89,90],"dysphagia","deglutition","deglutition disorders","swallowing","breathing","cough","swallowing disorders","heart transplant recipients","respiratory muscle strength training","2026-05-01",{"date":93,"type":94},"2026-05-07","ACTUAL",{"date":96,"type":94},"2024-05-17",{"date":98,"type":73},"2027-03-31",{"name":5,"class":6},1]