[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100453484":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":16,"locations":22,"responsibleParty":40,"collaborators":7,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":7,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":7,"studyType":57,"phases":7,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":25,"whyStopped":7,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Johannes Gutenberg University Mainz","OTHER",null,[9,13],{"name":10,"affiliation":11,"role":12},"Gunther J Pestel, M.D., Ph.D.","Johannes Gutenberg University Medical Center, Dpt. of Anesthesiology","STUDY_CHAIR",{"name":14,"affiliation":11,"role":15},"Kimiko Fukui-Dunkel, M.D., Ph.D.","STUDY_DIRECTOR",[17],{"name":18,"role":19,"phone":20,"phoneExt":7,"email":21},"Johannes M Wirkus, M.D.","CONTACT","+49 6131 17- 7175","johannes.wirkus@unimedizin-mainz.de",[23],{"facility":24,"status":25,"city":26,"state":27,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"Department of Anesthesiology, Johannes-Gutenberg University Medical Center","RECRUITING","Mainz","Rhineland-Palatinate","55131","Germany","DE",{"type":32,"coordinates":33},"Point",[34,35],8.28008,49.98185,{"lat":35,"lon":34},[38],{"name":18,"role":19,"phone":39,"phoneExt":7,"email":21},"+49 6131 17-0",{"type":41,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Johannes M Wirkus, MD","Principal Investigator Johannes Wirkus, M.D.","100453484","respiratory-variation-of-carotid-doppler-peak-velocity-cdpv-for-non-invasive-prediction-of-fluid-responsiveness-100453484",false,"NCT05185141","Respiratory Variation of Carotid Doppler Peak Velocity (CDPV) for Non-invasive Prediction of Fluid Responsiveness","Assessing Respiratory Variation of Carotid Doppler Peak Velocity (CDPV) for Non-invasive Prediction of Fluid Responsiveness During Abdominal Surgery: a Prospective Observational Trial","Inclusion Criteria:\n\n* Age 18-80 years\n* written informed consent\n* scheduled major abdominal surgery\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>80 years\n* pregnancy\n* SIRS or sepsis\n* any kind of cardiac arrhythmia\n* known valve disease\n* known heart failure\n* any kind of known carotid stenosis\n* carotid doppler peak velocity \\>182 cm\u002Fs before baseline measurement (expected stenosis)\n* missing indication for invasive arterial blood pressure monitoring (IBP) not related to the study\n* peripheral artery disease (PAD)\n* BMI \\> 35 kg\u002Fm2\n* intraabdominal hypertension\n* ASA-PSC of 4\n* severe lung disease (e.g. COPD grade 3, fibrosis)\n* esophageal disease of any kind\n* participation in another clinical study","ALL","18 Years","80 Years",{"count":55,"type":56},84,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to assess respiratory variation of carotid doppler peak velocity (∆CDPV) for prediction of fluid responsiveness during major abdominal surgery.",[60],"Hemodynamic Instability",[62,63,64,65,66],"Fluid Responsiveness","Hemodynamic Monitoring","Carotid Doppler Peak Velocity","Pulse Pressure Variation","Fluid Challenge","2026-06-09",{"date":69,"type":70},"2026-06-10","ACTUAL",{"date":72,"type":70},"2022-01-11",{"date":74,"type":56},"2026-07",{"name":5,"class":6},1]