[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100468784":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":21,"responsibleParty":39,"collaborators":10,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":10,"eligibilityCriteria":46,"healthyVolunteers":43,"sex":47,"minAge":10,"maxAge":48,"enrollmentInfo":49,"targetDuration":10,"studyType":52,"phases":10,"briefSummary":53,"conditions":54,"keywords":58,"overallStatus":23,"whyStopped":10,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":69},{"fullName":5,"class":6},"St. Jude Children's Research Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Pediatric Influenza Vaccine Recipients",null,"Pediatric patients eligible to receive seasonal influenza vaccine.",[13],{"name":14,"affiliation":5,"role":15},"Ramilo Octavio, MD","PRINCIPAL_INVESTIGATOR",[17],{"name":14,"role":18,"phone":19,"phoneExt":10,"email":20},"CONTACT","866-278-5833","referralinfo@stjude.org",[22],{"facility":5,"status":23,"city":24,"state":25,"zip":26,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"RECRUITING","Memphis","Tennessee","38105","United States","US",{"type":30,"coordinates":31},"Point",[32,33],-90.04898,35.14953,{"lat":33,"lon":32},[36,38],{"name":37,"role":18,"phone":19,"phoneExt":10,"email":20},"Ravilo Octavio, MD",{"name":14,"role":15,"phone":10,"phoneExt":10,"email":10},{"type":40,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100468784","response-to-influenza-vaccination-in-pediatric-oncology-patients-100468784",false,"NCT05384288","Response to Influenza Vaccination in Pediatric Oncology Patients","Inclusion Criteria:\n\n* Patient ≤ 18 years old at the time of consent receiving care at St. Jude Children's Research Hospital\n* Diagnosed with a hematological malignancy\n* Eligible to receive the current seasonal influenza vaccine\n\nExclusion Criteria:\n\n• Previously received at least one dose of the current seasonal influenza vaccine.","ALL","18 Years",{"count":50,"type":51},150,"ESTIMATED","OBSERVATIONAL","Influenza infection occurring during oncologic treatment or following hematopoietic cell transplantation (HCT) is associated with increased risk of morbidity in the form of lower respiratory tract infection (LRTI) and mortality relative to otherwise healthy patients. The study participants have been diagnosed with a hematological malignancy and are eligible to receive the current seasonal influenza (Flu) vaccine.\n\nPrimary Objective\n\n* To determine the feasibility of opening a longitudinal prospective study of IIV immunogenicity in pediatric leukemia patients.\n* To describe the immunogenicity, as measured by the development of cell- and\u002For antibody-mediated influenza specific responses 3 to 5 weeks following vaccination, in a cohort of pediatric leukemia patients.\n\nSecondary Objectives\n\n* To describe whether an immune response, as measured by development of cell- and\u002For antibody-mediated influenza specific responses, is detectable 1-2 weeks following vaccination in a cohort of pediatric leukemia patients.\n* To describe the durability of immunogenicity by measuring cell - and antibody- mediated influenza specific responses at 6 months and 1 year following vaccination in a cohort of pediatric leukemia patients.\n\nExploratory Objectives\n\n* To estimate the clinical effectiveness of influenza vaccine in this cohort by monitoring for the development of clinical diagnosis of influenza in the cohort of enrolled pediatric oncology patients.\n* To correlate results of immune cell frequency in blood, as measured by complete blood count with differential, with development of an immune response to IIV.",[55,56,57],"Hematologic Malignancy","Pediatric Cancer","Transplant-Related Cancer",[59],"Influenza infection","2026-06-11",{"date":62,"type":63},"2026-06-12","ACTUAL",{"date":65,"type":63},"2022-10-07",{"date":67,"type":51},"2029-12-01",{"name":5,"class":6},1]