[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623773":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":28,"locations":34,"responsibleParty":50,"collaborators":11,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":11,"enrollmentInfo":62,"targetDuration":11,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":37,"whyStopped":11,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Gødstrup Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Thirst-driven, liberal fluid intake","EXPERIMENTAL",null,[13],"Behavioral: Thirst-driven, liberal fluid intake",{"label":15,"type":16,"description":11,"interventionNames":17},"Fluid restriction","ACTIVE_COMPARATOR",[18],"Behavioral: Fluid restriction strategy",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"BEHAVIORAL","Fluid restriction strategy","Fluid restriction of 1.5 L\u002Fday",[15],{"type":21,"name":9,"description":26,"armGroupLabels":27,"otherNames":11},"Liberal fluid intake driven by thirst without restrictions",[9],[29],{"name":30,"role":31,"phone":32,"phoneExt":11,"email":33},"Anders Hostrup Larsen, MD, PhD","CONTACT","0045","anders.hostrup@rm.dk",[35],{"facility":36,"status":37,"city":38,"state":11,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Department of Cardiology, Gødstrup Hospital","RECRUITING","Herning","7400","Denmark","DK",{"type":43,"coordinates":44},"Point",[45,46],8.97662,56.13615,{"lat":46,"lon":45},[49],{"name":30,"role":31,"phone":32,"phoneExt":11,"email":33},{"type":51,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100623773","restrictive-versus-liberal-fluid-intake-in-acute-decompensated-heart-failure-100623773",false,"NCT07400991","Restrictive Versus Liberal Fluid Intake in Acute Decompensated Heart Failure","Restrictive Versus Liberal Fluid Intake in Acute Decompensated Heart Failure: a Randomized Trial","RELIEF-AHF","Inclusion Criteria:\n\n1. Age \\>18 years\n2. Hospitalized for ADHF as the primary diagnosis, meeting both of the following:\n\n   1. ≥1 documented symptom of new or worsening heart failure (dyspnea, fatigue, decreased exercise tolerance, or symptom of end-organ hypoperfusion).\n   2. Objective evidence of ADHF, defined as either:\n\n   i. ≥2 physical signs (edema, ascites, pulmonary rales\u002Fcrackles, increased JVP, S3 gallop, rapid weight gain due to fluid retention), OR ii. ≥1 physical sign AND ≥1 laboratory finding indicative of ADHF (BNP \\>500 ng\u002FL or NT-proBNP \\>2000 ng\u002FL if sinus rhythm, or BNP \\>750 ng\u002FL or NT-proBNP \\>3000 ng\u002FL if atrial fibrillation, radiological\u002Fultrasound evidence of pulmonary congestion, echocardiographic sign \\[VCI \\>2.1 cm, LVOT VTI \\\u003C15 cm, E\u002Fe' \\>14, D-dominant pulmonary venous inflow pattern\\], or invasive evidence \\[CVP \\>12 mmHg, PCWP \\>18 mmHg, CI \\\u003C2.2 L\u002Fmin\u002Fm2\\]).\n3. Treatment with ≥40 mg IV furosemide (or equivalent)\n4. Enrolment within 24 hours of admission\n5. Ability to provide informed consent\n\nExclusion Criteria:\n\n1. Requirement at admission for ICU-level care, or IV inotropic\u002Fvasopressor therapy for ADHF.\n2. Na+ \\\u003C125 mmol\u002FL or Na+ \\>145 mmol\u002FL.\n3. End-stage chronic kidney disease on chronic dialysis or eGFR \\\u003C15 mL\u002Fmin\u002F1.73 m2\n4. Any condition which would make participation unsafe or substantially affect protocol adherence, as judged by investigator.","ALL","18 Years",{"count":63,"type":64},420,"ESTIMATED","INTERVENTIONAL",[67],"NA","The aim of this clinical trial is to learn whether a thirst-driven, liberal fluid-intake strategy is comparable to a fluid-restriction strategy in patients hospitalized for acute decompensated heart failure (ADHF). The study will also assess the safety of the intervention and its effects on thirst and quality of life.\n\nPatients hospitalized with ADHF will be asked to follow either a thirst-driven fluid-intake strategy or a fluid-restriction strategy during their hospital stay and for one month after discharge.",[70],"Acute Heart Failure (AHF)",[72,73,74,75,76],"Fluid Restriction","Thirst-driven fluid intake","Liberal fluid intake","Acute heart failure","Time to clinical stability","2026-05-04",{"date":79,"type":80},"2026-05-07","ACTUAL",{"date":82,"type":80},"2026-05-01",{"date":84,"type":64},"2029-08",{"name":5,"class":6},1]