[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626825":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":44,"responsibleParty":61,"collaborators":25,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":25,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":25,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":87,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Nigde Omer Halisdemir University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Restrictive intraoperative fluid strategy (≤3 mL\u002Fkg\u002Fh)","EXPERIMENTAL","Participants undergoing elective cesarean section under spinal anesthesia will receive intraoperative crystalloid at a target average infusion rate of ≤3 mL\u002Fkg\u002Fh. Standardized spinal anesthesia technique and intraoperative management will be applied. Hypotension will be treated according to the predefined rescue protocol (e.g., ephedrine and\u002For additional fluid bolus as clinically indicated).",[13],"Other: Restrictive intraoperative crystalloid fluid strategy (≤3 mL\u002Fkg\u002Fh)",{"label":15,"type":16,"description":17,"interventionNames":18},"Liberal intraoperative fluid strategy (>3 mL\u002Fkg\u002Fh)","ACTIVE_COMPARATOR","Participants undergoing elective cesarean section under spinal anesthesia will receive intraoperative crystalloid at a target average infusion rate of \\>3 mL\u002Fkg\u002Fh. Standardized spinal anesthesia technique and intraoperative management will be applied. Hypotension will be treated according to the predefined rescue protocol (e.g., ephedrine and\u002For additional fluid bolus as clinically indicated).",[19],"Other: Liberal intraoperative crystalloid fluid strategy (>3 mL\u002Fkg\u002Fh)",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Restrictive intraoperative crystalloid fluid strategy (≤3 mL\u002Fkg\u002Fh)","Intraoperative crystalloid administration targeting an average rate of ≤3 mL\u002Fkg\u002Fh during elective cesarean section under spinal anesthesia.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Liberal intraoperative crystalloid fluid strategy (>3 mL\u002Fkg\u002Fh)","Intraoperative crystalloid administration targeting an average rate of \\>3 mL\u002Fkg\u002Fh during elective cesarean section under spinal anesthesia.",[15],[31],{"name":32,"affiliation":33,"role":34},"Pınar Erdoğan, Assoc Prof","Niğde Ömer Halisdemir University Hospital","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Pınar Erdoğan, Assoc. Prof.","CONTACT","+905233646954","pinar.erdogan@ohu.edu.tr",{"name":42,"role":38,"phone":43,"phoneExt":25,"email":40},"Seval Kılbasanlı, MD","+905057246364",[45],{"facility":33,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":25,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Niğde","Merkez","51240","Turkey (Türkiye)",{"type":52,"coordinates":53},"Point",[54,55],34.67935,37.96583,{"lat":55,"lon":54},[58],{"name":37,"role":38,"phone":59,"phoneExt":25,"email":60},"05233646954","drpinarerdogan@gmail.com",{"type":34,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Seval KILBASANLI","MD","100626825","restrictive-vs-liberal-intraoperative-fluid-strategy-and-postoperative-outcomes-after-elective-cesarean-section-100626825",false,"NCT07440667","Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section","A Prospective Randomized Controlled Trial Comparing Restrictive and Liberal Intraoperative Fluid Strategies on Postoperative Nausea and Vomiting and Gastrointestinal Recovery After Elective Cesarean Section Under Spinal Anesthesia","Inclusion Criteria:\n\n* Female patients aged 18-45 years\n* ASA physical status II\n* Scheduled for elective cesarean section under spinal anesthesia\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Emergency cesarean section\n* Preeclampsia or eclampsia\n* Known cardiac failure\n* Known renal failure\n* Known hepatic failure\n* Coagulopathy\n* Contraindication to spinal anesthesia\n* Conversion to general anesthesia\n* Major technical complications during spinal anesthesia\n* Refusal to participate","FEMALE","18 Years","45 Years",{"count":75,"type":76},160,"ESTIMATED","INTERVENTIONAL",[79],"NA","Spinal anesthesia for elective cesarean section is frequently associated with hemodynamic instability and postoperative complications such as postoperative nausea and vomiting (PONV) and delayed gastrointestinal recovery. Although intraoperative fluid administration is routinely used to prevent spinal-induced hypotension, the optimal fluid strategy remains unclear. Both restrictive and liberal fluid approaches may influence maternal hemodynamics and postoperative outcomes through different physiological mechanisms.\n\nThis prospective, single-center, randomized controlled trial aims to compare restrictive (≤3 mL\u002Fkg\u002Fh) and liberal (\\>3 mL\u002Fkg\u002Fh) intraoperative crystalloid fluid strategies in patients undergoing elective cesarean section under spinal anesthesia. The primary outcome is the incidence of PONV within the first 24 hours postoperatively. Secondary outcomes include postdural puncture headache (PDPH), time to first flatus, hypotension frequency, and vasopressor requirements.",[82,83,84,85,86],"Cesarean Section","Postoperative Nausea and Vomiting (PONV)","Postdural Puncture Headache (PDPH)","Postoperative Ileus","Gastrointestinal Recovery",[82,88,89,90,91,92,93,86,94,95],"Spinal Anesthesia","Intraoperative Fluid Therapy","Restrictive Fluid Strategy","Liberal Fluid Strategy","Postoperative Nausea and Vomiting","Postdural Puncture Headache","Hypotension","Vasopressor Use","2026-03-07",{"date":98,"type":99},"2026-03-10","ACTUAL",{"date":101,"type":99},"2026-03-04",{"date":103,"type":76},"2027-01-30",{"name":5,"class":6},1]