[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100303705":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":30,"locations":35,"responsibleParty":52,"collaborators":54,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":10,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":10,"enrollmentInfo":72,"targetDuration":10,"studyType":75,"phases":10,"briefSummary":76,"conditions":77,"keywords":93,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},{"fullName":5,"class":6},"Duke University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Case",null,"Patients with (MCI, PD, AD, FTD, DLB, ALS, MS, HD, TBI, concussion, PTSD and other neurodegenerations as well as Down Syndrome)",[13],"Device: Retinal and Choroidal Imaging",{"label":15,"type":10,"description":16,"interventionNames":17},"Controls","Controls will be recruited from the relatives\u002Fattendants of study participants or will be patients themselves and will not have a neurodegenerative disease diagnosis.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DEVICE","Retinal and Choroidal Imaging","Non-invasive OCT, OCTA, and UWF fundus photography of retina",[9,15],[25,28],{"name":26,"affiliation":5,"role":27},"Sharon Fekrat, MD FACS FASRS","PRINCIPAL_INVESTIGATOR",{"name":29,"affiliation":5,"role":27},"Dilraj Grewal, MD",[31],{"name":26,"role":32,"phone":33,"phoneExt":10,"email":34},"CONTACT","919-681-3937","imind@duke.edu",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Duke University Medical Center","RECRUITING","Durham","North Carolina","27705","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-78.89862,35.99403,{"lat":48,"lon":47},[51],{"name":26,"role":32,"phone":33,"phoneExt":10,"email":34},{"type":53,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[55,58,60],{"name":56,"class":57},"University of Edinburgh in Scotland","UNKNOWN",{"name":59,"class":57},"Tan Tock Seng Hospital in Singapore",{"name":61,"class":57},"Queens University of Belfast United Kingdom","100303705","retinal-imaging-in-neurodegenerative-disease-100303705",false,"NCT03233646","Retinal Imaging in Neurodegenerative Disease","Evaluating the Retinal and Choroidal Microvasculature and Structure Using Multimodal Retinal and Choroidal Imaging in Neurodegenerative Disease: iMIND Research Study","Inclusion Criteria:\n\n* Adults with neurodegenerative disease ((MCI, PD, AD, FTD, DLB, ALS, MS, HD, TBI, concussion, PTSD and other neurodegenerations as well as Down Syndrome)\n* Adults without neurodegenerative disease\n\nExclusion Criteria:\n\n* Inability to cooperate with or complete testing or other neurologic or age- related ocular conditions that would impact image acquisition.\n* Eyes that have had intraocular surgery, other than cataract surgery.\n\nIf two eyes satisfy the inclusion criteria, both eyes will be included in the study. If one eye satisfies the inclusion criteria, the eye that qualifies will be included in the study.",true,"ALL","18 Years",{"count":73,"type":74},2000,"ESTIMATED","OBSERVATIONAL","This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.",[78,79,80,81,82,83,84,85,86,87,88,89,90,91,92],"Alzheimer's Disease","Mild Cognitive Impairment","Parkinson's Disease","Multiple Sclerosis","Huntington Disease","Lewy Body Dementia","Frontotemporal Dementia","Amyotrophic Lateral Sclerosis (ALS)","APOE-4 Positive","Traumatic Brain Injury","Concussion","Post-Traumatic Stress Disorder","Down Syndrome","Neuro-Degenerative Disease","Normal Cognition",[94,95,96,97,98,99,100,101,102,103,104],"OCT angiography (OCTA)","Optical Coherence Tomography (OCT)","Vessel Density","Superficial Capillary Plexus","Retinal microvasculature","Scanning Laser Ophthalmoscopy","Ultra-widefield (UWF) Imaging","Perfusion Density","Retinal Nerve Fiber Layer","Ganglion Cell Inner Plexiform Layer","Choroidal Vascularity Index","2026-02-02",{"date":107,"type":108},"2026-02-04","ACTUAL",{"date":110,"type":108},"2017-07-20",{"date":112,"type":74},"2026-12-31",{"name":5,"class":6},1]