[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100563846":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":39,"centralContacts":43,"locations":50,"responsibleParty":66,"collaborators":30,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":30,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":30,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":30,"overallStatus":52,"whyStopped":30,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"• Group R: Retrolaminar block (RLB)","EXPERIMENTAL","Patients will receive bilateral ultrasound guided retrolaminar block with injection of 20 ml bupivacaine 0.25% in each side.",[13],"Procedure: Retrolaminar block group",{"label":15,"type":10,"description":16,"interventionNames":17},"Group T. Subcostal transversus abdominis plane block (STAP)","Patients will receive bilateral Ultrasound guided subcostal TAP with injection of 20 ml bupivacaine 0.25% in each side.",[18],"Other: subcostal TAP technique",{"label":20,"type":10,"description":21,"interventionNames":22},"Epidural","By loss of resistant technique and catheter insertion at the level of thoracic vertebrae (7-10)",[23],"Other: thoracic Epidural",[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"PROCEDURE","Retrolaminar block group","patients will be placed in a sitting position. The transducer will be positioned vertically 3 cm lateral to the midline at the level of the 7th thoracic transverse process. The muscles of the back, the transverse process, and the pleura between two transverse processes will be visualized. The needle will be introduced in a cranial-caudal direction toward the lamina using the in-plane method until the tip lay in the lamina 1 mL of normal saline will be injected to confirm the correct needle tip position by visualizing the spread. After negative aspiration, 20 mL of 0.25% isobaric bupivacaine. The procedure will be repeated on the opposite side.",[9],null,{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"subcostal TAP technique","The transducer will be placed obliquely along the subcostal margin near the xiphisternum in the midline of the abdomen. The rectus abdominis muscle and underlying transversus abdominis muscle will be identified. The position of the transversus abdominis muscle will be confirmed by sliding the transducer laterally until the aponeuroses of the external and internal oblique muscle will be visualized. The transversus abdominis muscle will be then identified, being posterior to the internal oblique muscle and will be followed back medially to confirm its position beneath the rectus muscle. the needle will be introduced through the rectus muscle in a superomedial-to-inferolateral direction towards the transversus abdominis muscle using the in-plane method, and 20 mL of 0.25% isobaric bupivacaine will be injected",[15],{"type":6,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"thoracic Epidural","Before induction of general anesthesia the epidural catheter was inserted under sterile condition with a loss of resistance technique by an 18G needle at a mid-thoracic level (Th 7-10) to cover the dermatomes innervating the incision in the upper abdomen. The epidural infusion consisting of bupivacaine 1 mg\u002FmL, and fentanyl 2 μg\u002FmL was activated on the attending anesthesiologist's decision. Following the hospital protocols, the infusion rate was initiated at 5-10 mL\u002Fh, increased to maximum 15 mL\u002Fh if necessary, bolus dose of 5 mL was allowed every 30 minutes.",[20],[40],{"name":41,"affiliation":5,"role":42},"sayed M Abed","PRINCIPAL_INVESTIGATOR",[44],{"name":45,"role":46,"phone":47,"phoneExt":48,"email":49},"sayed M abed, MD degree","CONTACT","1226806532","+20","sydabed2020@outlook.com",[51],{"facility":5,"status":52,"city":53,"state":30,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"RECRUITING","Cairo","11835","Egypt","EG",{"type":58,"coordinates":59},"Point",[60,61],31.24967,30.06263,{"lat":61,"lon":60},[64],{"name":45,"role":46,"phone":65,"phoneExt":48,"email":49},"01226806532",{"type":42,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Sayed Mahmoud Abed","assistant professor","100563846","retrolaminar-block-versus-subcostal-transversus-abdominis-plane-block-in-liver-resection-surgery-100563846",false,"NCT06621472","Retrolaminar Block Versus Subcostal Transversus Abdominis Plane Block in Liver Resection Surgery","Retrolaminar Block Versus Subcostal Transversus Abdominis Plane Block in Patients Undergoing Open Liver Resection Surgery","Inclusion Criteria:\n\nPhysical status American Society of Anesthesiologists (ASA)II, III. Body mass index (BMI): 20-35 kg\u002Fm2.\n\nExclusion Criteria:\n\nPatient refusal Physical status ASA IV BMI \\< 20 kg\u002Fm2 and \\>35 kg\u002Fm2 known sensitivity or contraindication to drug used in the study (local anesthetics, opioids).\n\nHistory of psychological disorders and\u002For chronic pain. Contraindication to regional anesthesia e.g., local sepsis, pre- existing peripheral neuropathies, and coagulopathy.\n\nSevere respiratory, cardiac disorders and renal disease.","ALL","18 Years","65 Years",{"count":80,"type":81},90,"ESTIMATED","INTERVENTIONAL",[84],"NA","Adequate pain control improves postoperative outcomes and is imperative for enhanced recovery after surgery (ERAS) . Open liver resection surgery is associated with intraoperative blood loss, hypotension, coagulopathy, pulmonary complications, liver impairment, and renal impairment, making perioperative pain management challenging . Multimodal analgesic strategies employing regional techniques decrease postoperative pain and opioid consumption following liver resections. Thoracic epidural analgesia (TEA) is considered the 'gold standard' for open thoracic and abdominal surgical procedures .",[87],"Cancer Liver","2026-03-16",{"date":90,"type":91},"2026-03-18","ACTUAL",{"date":93,"type":91},"2024-10-01",{"date":95,"type":81},"2026-06-01",{"name":5,"class":6},1]