[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100223978":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":30,"locations":36,"responsibleParty":62,"collaborators":64,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":34,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":34,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":53,"whyStopped":34,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Yale University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Lifestyle Intervention","EXPERIMENTAL","Caloric Restriction to reverse lipid-induced insulin resistance.",[13],"Behavioral: Caloric Restriction",{"label":15,"type":10,"description":16,"interventionNames":17},"Baseline Assessment of Hepatic Mitochondrial Fat Oxidation","Tracer study to assess hepatic mitochondrial fat oxidation (PINTA).",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","Caloric Restriction","Dietary intervention to reduce lipid content in liver and muscle with minimal overall weight loss. Weekly visits for measurements of body weight, body composition, blood glucose and MRS measurements of liver and muscle lipid.",[15,9],[25],"Dietary intervention to reduce lipid content in liver and muscle with minimal overall weight loss.",[27],{"name":28,"affiliation":5,"role":29},"Kitt Petersen, MD","PRINCIPAL_INVESTIGATOR",[31],{"name":28,"role":32,"phone":33,"phoneExt":34,"email":35},"CONTACT","203-785-5447",null,"kitt.petersen@yale.edu",[37,51],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":34},"Magnetic Resonance Research Center (MRRC)","ENROLLING_BY_INVITATION","New Haven","Connecticut","06511","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-72.92816,41.30815,{"lat":49,"lon":48},{"facility":52,"status":53,"city":40,"state":41,"zip":54,"country":43,"countryCode":44,"cosmosGeoPoint":55,"geoPoint":57,"contacts":58},"Yale Center for Clinical Investigation HRU","RECRUITING","06520",{"type":46,"coordinates":56},[48,49],{"lat":49,"lon":48},[59,61],{"name":28,"role":32,"phone":60,"phoneExt":34,"email":34},"203-688-4106",{"name":28,"role":29,"phone":34,"phoneExt":34,"email":34},{"type":63,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR",[65],{"name":66,"class":67},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH","100223978","reversal-of-lipid-induced-insulin-resistance-100223978",false,"NCT02193295","Reversal of Lipid-Induced Insulin Resistance","Inclusion Criteria:\n\n* Healthy, sedentary, non-smoking and not taking any medications other than birth control pills.\n* Hematocrit \\>35%\n* Subjects will have no systemic or organ disease including diabetes.\n* Subjects will have no history eating disorders.\n* Women must be using a form of birth control (sexual abstinence, birth control pills, Norplant, IUD or condoms) and will be studied between day 0 and 7 of their menstrual cycle.\n* Those who are taking birth control pills or have had a hysterectomy may be studied at any time.\n* Physical activity will be assessed using a standard questionnaire with an activity index cut off at 2.3.\n\nExclusion Criteria:\n\n* Any subject, who does not fit the inclusion criteria. Including history of eating disorders, any systemic and organ disease including diabetes.\n\nLactose intolerance Any blood count, clotting abnormalities HYpertriglyceridemeia (TG over 100 mg\u002FdL)\n\n* Hematocrit \\\u003C35%.\n* Women of childbearing potential, who are not using contraception (as mentioned above) or who are not abstinent.\n* Subjects who have a regular exercise regimen will not be enrolled.\n* Metal implants and\u002For body piercing, which cannot be removed before the MR studies.",true,"ALL","18 Years","90 Years",{"count":79,"type":80},250,"ESTIMATED","INTERVENTIONAL",[83],"NA","The purpose of this study is to examine whether weight reduction decreases intramyocellular (IMCL) and hepatic lipid content, and improves insulin sensitivity of muscle and fat tissue in people who are insulin resistant and have a family history of type 2 diabetes.\n\nHepatic mitochondrial oxidation will be assesses using a 3 hour triple tracer study (D7 glucose, 3-13C lactate and 13C4 beta-hydroxybutyrate).",[86,87],"Insulin Resistance","NAFLD",[89,21,90,91,92],"Weight Reduction","Euglycemic Hyperinsulinemic Clamp","Magnetic Resonance Spectroscopy","PINTA","2026-06-17",{"date":95,"type":96},"2026-06-22","ACTUAL",{"date":98,"type":96},"2002-10",{"date":100,"type":80},"2034-12",{"name":5,"class":6},2]