[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100527492":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":19,"responsibleParty":48,"collaborators":7,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":53,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":7,"studyType":65,"phases":7,"briefSummary":66,"conditions":67,"keywords":71,"overallStatus":21,"whyStopped":7,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Hospital Civil de Guadalajara","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"Miguel Ibarra Estrada, MD","Hospital Civil Fray Antonio Alcalde","PRINCIPAL_INVESTIGATOR",[14],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},"Miguel Ibarra-Estrada, MD","CONTACT","+523317593502","drmiguelibarra@hotmail.com",[20],{"facility":11,"status":21,"city":22,"state":7,"zip":23,"country":24,"countryCode":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":32},"RECRUITING","Guadalajara","44280","Mexico","MX",{"type":27,"coordinates":28},"Point",[29,30],-103.34749,20.67738,{"lat":30,"lon":29},[33,35,38,41,43,45,46],{"name":15,"role":16,"phone":34,"phoneExt":7,"email":18},"3317593502",{"name":36,"role":16,"phone":7,"phoneExt":7,"email":37},"Guadalupe Aguirre-Avalos, MD","guadalupe.aavalos@academicos.udg.mx",{"name":39,"role":40,"phone":7,"phoneExt":7,"email":7},"Quetzalcóatl Chávez-Peña, MD","SUB_INVESTIGATOR",{"name":42,"role":40,"phone":7,"phoneExt":7,"email":7},"Arnulfo López-Pulgarín, MD",{"name":44,"role":40,"phone":7,"phoneExt":7,"email":7},"Guadalupe Aguirre-Avalos, PhD",{"name":15,"role":12,"phone":7,"phoneExt":7,"email":7},{"name":47,"role":40,"phone":7,"phoneExt":7,"email":7},"David Hernández-Lugo, MD",{"type":12,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Miguel Á Ibarra-Estrada","MD","100527492","reverse-trigger-phenotypification-and-response-to-ventilatory-adjustments-100527492",false,"NCT06148467","Reverse Trigger Phenotypification and Response to Ventilatory Adjustments","Incidence of Reverse Trigger Phenotypes and Response to Ventilatory Adjustments in Patients With ARDS","RT-CHASERS","Inclusion Criteria:\n\n* Diagnosis of ARDS according to the Berlin criteria and added New Global Definition 2023\n* Mechanical ventilation\n\nExclusion Criteria:\n\n* \\\u003C18 years\n* Tracheostomy status\n* Pneumothorax\n* Tube thoracostomy with air leaks","ALL","18 Years","90 Years",{"count":63,"type":64},130,"ESTIMATED","OBSERVATIONAL","The goal of this prospective observational study is to describe the incidence of reverse trigger (RT) in mechanically ventilated patients with diagnosis of acute respiratory distress syndrome (ARDS).\n\nThe main questions it aims to answer are:\n\n* Real incidence of RT based on continuous monitoring\n* The response to mechanical ventilatiory adjustments Participants will be included as soon as neuromuscular blockers (NMB)\u002Fsedation is stopped or in case of spontaneous respiratory efforts detection, whatever happens first. Continuous monitoring will be performed by esophageal manometry until switch to a pressure support (spontaneous) mode, restart of deep sedation\u002Fneuromuscular blockers by medical indication, or death.\n\nIn order to allow detection of possible RT in patients with ongoing sedation\u002FNMB, mechanical ventilator waveforms will be screened every 1-2 hours by investigators and critical care physicians with at least 1 year of specific training in detection of dyssynchronies.",[68,69,70],"Reverse Trigger","Acute Respiratory Distress Syndrome","Mechanical Ventilation",[72,69,73,70],"Reverse trigger","Dyssynchony","2025-03-15",{"date":76,"type":77},"2025-03-18","ACTUAL",{"date":79,"type":77},"2023-11-17",{"date":81,"type":64},"2026-02-01",{"name":5,"class":6},1]