[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636525":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":17,"centralContacts":24,"locations":17,"responsibleParty":30,"collaborators":17,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":40,"eligibilityCriteria":41,"healthyVolunteers":36,"sex":42,"minAge":43,"maxAge":17,"enrollmentInfo":44,"targetDuration":17,"studyType":47,"phases":48,"briefSummary":50,"conditions":51,"keywords":56,"overallStatus":59,"whyStopped":17,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":17},{"fullName":5,"class":6},"Sixth Affiliated Hospital, Sun Yat-sen University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"r-PVB","EXPERIMENTAL","Participants in this arm will receive Revised-Paravertebral Nerve Block (r-PVB) after induction of general anesthesia and before the start of surgery.",[13],"Procedure: Revised-Paravertebral Nerve Block",{"label":15,"type":16,"description":17,"interventionNames":17},"Control","NO_INTERVENTION",null,[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":17},"PROCEDURE","Revised-Paravertebral Nerve Block","Revised-Paravertebral Nerve Block (r-PVB) is performed after induction of general anesthesia and before the start of surgery. Under ultrasound guidance, an intercostal space between the 7th and 9th ribs at the midaxillary line is identified. Using an in-plane technique, the needle is advanced into the internal intercostal muscle, and 30 mL of 0.5% ropivacaine is injected to achieve the block.",[9],[25],{"name":26,"role":27,"phone":28,"phoneExt":17,"email":29},"Xiangcai Ruan, MD","CONTACT","+86 13760710099","ruanxc@mail.sysu.edu.cn",{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":17,"oldOrganization":17},"PRINCIPAL_INVESTIGATOR","Xiangcai Ruan, MD, PhD","Professor","100636525","revised-paravertebral-nerve-blocks-for-enhanced-recovery-after-laparoscopic-cholecystectomy-100636525",false,"NCT07566819","Revised-Paravertebral Nerve Blocks for Enhanced Recovery After Laparoscopic Cholecystectomy","Revised-Paravertebral Nerve Blocks for Enhanced Recovery After Laparoscopic Cholecystectomy: A Randomized Clinical Trial","REVISED-PVB II","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective laparoscopic cholecystectomy for benign gallbladder disease\n\nExclusion Criteria:\n\n* Contraindications to nerve block, including skin infection at the puncture site, increased intracranial pressure, uncorrectable coagulopathy, bridging indication for therapeutic anticoagulation (CHADS-VASc ≥ 8), sepsis, or allergy to local anesthetics\n* Surgeon-estimated high likelihood of conversion to open surgery\n* Chronic opioid use\n* Heart failure, liver failure, or renal failure\n* Coagulation disorders\n* History of allergy to local anesthetics\n* Inability to comply with the study protocol, including severe psychiatric illness, refusal to provide informed consent, or anticipated difficulty with postoperative follow-up","ALL","18 Years",{"count":45,"type":46},250,"ESTIMATED","INTERVENTIONAL",[49],"NA","After laparoscopic cholecystectomy, pain remains an important problem affecting patient recovery. A revised paravertebral block (r-PVB) was developed as a single-shot, large-volume intercostal-space injection performed at the exposed mid-axillary eighth or ninth intercostal level with the patient kept supine after induction of anesthesia. Rather than puncturing the classical paraspinal target near the transverse process with a specific prone or lateral position of the patient, r-PVB is designed to exploit medial spread of local anesthetic along the intercostal-endothoracic-extrapleural continuum, thereby generating a functional paravertebral block while avoiding direct entry into the paravertebral space and specific body positioning. r-PVB addresses several practical limitations of conventional PVB by eliminating the need to reposition an anesthetized patient, using a more accessible and potentially clearer sonographic window, reducing interference from transverse-process shadowing, and facilitating in-plane needle visualization.",[52,53,54,55],"Benign Gallbladder Disease","Laparoscopic Cholecystectomy","Postoperative Pain","Quality of Recovery",[53,54,55,57,58],"Paravertebral Nerve Block","intercostal space block","NOT_YET_RECRUITING","2026-05-06",{"date":62,"type":63},"2026-05-11","ACTUAL",{"date":65,"type":46},"2026-04-27",{"date":67,"type":46},"2027-12-31",{"name":5,"class":6}]