[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636916":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":17,"centralContacts":24,"locations":17,"responsibleParty":30,"collaborators":17,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":40,"eligibilityCriteria":41,"healthyVolunteers":36,"sex":42,"minAge":43,"maxAge":17,"enrollmentInfo":44,"targetDuration":17,"studyType":47,"phases":48,"briefSummary":50,"conditions":51,"keywords":55,"overallStatus":60,"whyStopped":17,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":17},{"fullName":5,"class":6},"Sixth Affiliated Hospital, Sun Yat-sen University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"r-PVB","EXPERIMENTAL","Participants in this arm will receive Revised-Paravertebral Nerve Block (r-PVB) after induction of general anesthesia and before the start of surgery.",[13],"Procedure: Revised-Paravertebral Nerve Block",{"label":15,"type":16,"description":17,"interventionNames":17},"Control","NO_INTERVENTION",null,[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":17},"PROCEDURE","Revised-Paravertebral Nerve Block","Participants assigned to the intervention group will receive an ultrasound-guided revised paravertebral block (r-PVB) after induction of general anesthesia and before surgical incision. With the patient in the supine position and the ipsilateral arm abducted, a high-frequency linear ultrasound probe is placed at the mid-axillary line to identify the ninth to eleventh intercostal space on the operative side, together with the pleura and intercostal muscle layers. Using an in-plane technique, the block needle is advanced under real-time ultrasound guidance into the plane of the internal intercostal muscle. Correct needle tip placement is confirmed by small test injections producing characteristic pleural displacement on ultrasound. After confirmation, 30 mL of 0.5% ropivacaine is injected into the target plane to achieve a functional paravertebral block. Routine surgery then proceeds.",[9],[25],{"name":26,"role":27,"phone":28,"phoneExt":17,"email":29},"Xiangcai Ruan, MD","CONTACT","+86 13760710099","ruanxc@mail.sysu.edu.cn",{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":17,"oldOrganization":17},"PRINCIPAL_INVESTIGATOR","Xiangcai Ruan, MD, PhD","Professor","100636916","revised-paravertebral-nerve-blocks-for-enhanced-recovery-after-stoma-closure-100636916",false,"NCT07571902","Revised-Paravertebral Nerve Blocks for Enhanced Recovery After Stoma Closure","Revised-Paravertebral Nerve Blocks for Enhanced Recovery After Stoma Closure: A Randomized Clinical Trial","r-PVB III","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Patients scheduled to undergo elective ileostomy, colostomy, or ileocolostomy reversal surgery.\n\nExclusion Criteria:\n\n* Contraindications to nerve block, including skin infection at the puncture site, increased intracranial pressure, uncorrectable coagulopathy, bridging indication for therapeutic anticoagulation (CHADS-VASc ≥8), sepsis, or allergy to local anesthetics.\n* Expected operative time longer than 150 minutes, or stoma reversal not being the primary surgical procedure.\n* Chronic opioid use.\n* Heart failure, liver failure, renal failure, coagulation disorders, or a history of allergy to local anesthetics.\n* Inability to comply with study procedures, including severe psychiatric illness, refusal to sign informed consent, or anticipated difficulty in completing postoperative follow-up.","ALL","18 Years",{"count":45,"type":46},250,"ESTIMATED","INTERVENTIONAL",[49],"NA","After stoma closure, pain remains an important problem affecting patient recovery. A revised paravertebral block (r-PVB) was developed as a single-shot, large-volume intercostal-space injection performed at the exposed mid-axillary ninth to eleventh intercostal level with the patient kept supine after induction of anesthesia. Rather than puncturing the classical paraspinal target near the transverse process with the patient in a prone or lateral position, the r-PVB technique is designed to exploit retrograde spread of local anesthetic from the intercostal space to the paravertebral space, thereby generating a functional paravertebral block while avoiding direct entry into the paravertebral space and the need for specific body positioning. The r-PVB technique addresses several practical limitations of conventional PVB by eliminating the need to reposition an anesthetized patient, using a more accessible and potentially clearer sonographic window, reducing interference from transverse-process shadowing, and facilitating in-plane needle visualization.",[52,53,54],"Stoma Closure","Postoperative Pain","Quality of Recovery",[52,56,57,53,54,58,59],"Ileostomy Closure","Colostomy Closure","Intercostal Space Block","Paravertebral Nerve Block","NOT_YET_RECRUITING","2026-05-06",{"date":63,"type":64},"2026-05-11","ACTUAL",{"date":66,"type":46},"2026-04-27",{"date":68,"type":46},"2027-12-31",{"name":5,"class":6}]