[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100587902":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":27,"centralContacts":32,"locations":41,"responsibleParty":80,"collaborators":10,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":85,"sex":91,"minAge":92,"maxAge":10,"enrollmentInfo":93,"targetDuration":10,"studyType":96,"phases":10,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":44,"whyStopped":10,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},{"fullName":5,"class":6},"Centro Hospitalar Universitario do Algarve","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Single-Session Ultrasound-Guided Genicular Nerve Radiofrequency Ablation in Patients With Knee Osteo",null,"Participants with knee osteoarthrosis (Kellgran-Lawrence III or IV) will receive a single-session ultrasound-guided radiofrequency ablation of the genicular nerves. The procedure targets three specific nerve branches around the knee joint: the superomedial, superolateral, and inferomedial genicular nerves. The targeted positions are based on anatomical reference points described by Fonkoue et al. (2021) and validated in cadaveric studies, aiming to improve the accuracy of nerve localization. Under ultrasound guidance, the clinician will insert a radiofrequency needle at each target site. After confirming correct positioning through sensory and motor stimulation, thermal ablation will be performed at 85ºC for 90 seconds per site. Local anesthesia will be administered before each ablation to ensure patient comfort. This procedure aims to reduce knee pain and improve function in patients with moderate to severe knee joint degeneration who have not responded to conservative treatments.",[13],"Device: Ultrasound-Guided Genicular Nerve Radiofrequency Ablation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Ultrasound-Guided Genicular Nerve Radiofrequency Ablation","This intervention involves a single-session ultrasound-guided thermal radiofrequency ablation of the superomedial, superolateral, and inferomedial genicular nerves in patients with moderate to severe knee osteoarthritis. Target points follow anatomical references described by Fonkoue et al. and validated in cadaveric studies, differing from classical approaches. Under ultrasound guidance, monopolar RF cannulas are placed, with sensory and motor stimulation confirming accurate positioning. Local anesthesia (2% lidocaine) is applied. Lesions are performed at 85°C for 90 seconds per site. The radiofrequency generator used is CE-marked for pain procedures. The study evaluates a novel targeting protocol, not the safety or effectiveness of the device itself. No fluoroscopy is used. The procedure is performed once. Participants are followed for two years to assess outcomes.",[9],[21,22,23,24,25,26],"Thermal Radiofrequency Ablation of Genicular Nerves","Monopolar Radiofrequency Ablation of Knee Nerves","Image-Guided Genicular Nerve Ablation","Ultrasound-Guided RFA of Knee","Genicular Nerve RFA","RFA for Knee Osteoarthritis Pain",[28],{"name":29,"affiliation":30,"role":31},"Manuel Tomás Farinha Caroço, Medical Doctor","Unidade Local de Saude do Algarve \u002F Centro Hospitalar Universitario Algarve","PRINCIPAL_INVESTIGATOR",[33,37],{"name":29,"role":34,"phone":35,"phoneExt":10,"email":36},"CONTACT","+351968010683","farinhacaroco@gmail.com",{"name":38,"role":34,"phone":39,"phoneExt":10,"email":40},"Giovanni Leoni, Medical Doctor","+39 328 613 3631","gioleoni95@gmail.com",[42,63],{"facility":43,"status":44,"city":45,"state":10,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Serviço de Medicina Física e de Reabilitação - Hospital de Faro - Unidade Local de Saúde do Algarve","RECRUITING","Faro","8000-386","Portugal","PT",{"type":50,"coordinates":51},"Point",[52,53],-7.92716,37.01869,{"lat":53,"lon":52},[56,58,62],{"name":29,"role":34,"phone":57,"phoneExt":10,"email":36},"968010683",{"name":59,"role":34,"phone":60,"phoneExt":10,"email":61},"Daniela Teixeira, Medical Doctor","+351 914 511 022","danielaspteixeira@gmail.com",{"name":29,"role":31,"phone":10,"phoneExt":10,"email":10},{"facility":64,"status":65,"city":66,"state":10,"zip":67,"country":47,"countryCode":48,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Serviço de Medicina Física e de Reabilitação - Hospital de São Francisco Xavier - Unidade Local de Saúde de Lisboa Ocidental","NOT_YET_RECRUITING","Lisbon","1449-005",{"type":50,"coordinates":69},[70,71],-9.1498,38.72509,{"lat":71,"lon":70},[74,75,79],{"name":38,"role":34,"phone":39,"phoneExt":10,"email":40},{"name":76,"role":34,"phone":77,"phoneExt":10,"email":78},"Jorge Barbosa, Medical Doctor","+351 914 729 415","jbarbosa@chlo.min-saude.pt",{"name":38,"role":31,"phone":10,"phoneExt":10,"email":10},{"type":31,"investigatorFullName":81,"investigatorTitle":82,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Manuel Tomás Farinha Caroço","Medical Doctor","100587902","revised-targets-for-knee-radiofrequency-ablation-100587902",false,"NCT06934421","Revised Targets for Knee Radiofrequency Ablation","Segurança e eficácia de Nova Abordagem Ecoguiada de ablação Por radiofrequência Dos Nervos Geniculados","ReTaKRA","Inclusion Criteria:\n\n* Patients with chronic knee pain related to radiographic knee osteoarthritis, Kellgren-Lawrence (KL) grade III or IV, who are refractory to conservative treatment.\n\n(Refractoriness to conservative treatment is defined as:\n\n* Persistent pain and functional limitation after undergoing knee-targeted physiotherapy and analgesic medication in accordance with clinical guidelines for osteoarthritis \\[e.g., paracetamol, nonsteroidal anti-inflammatory drugs, and other drugs as deemed appropriate by the treating physician\\];\n* Persistent pain and functional limitation after intra-articular corticosteroid injections or limited success with such interventions.)\n\nExclusion Criteria:\n\n* Patients with previous knee arthroplasty\n* Patients who have undergone prior radiofrequency (RF) ablation\n* Significant psycho-emotional disorders\n* Addictive behaviors\n* Generalized pain\n* Nociplastic pain\n* Presence of a pacemaker\n* Presence of osteosynthesis material in the knee or adjacent anatomical regions","ALL","18 Years",{"count":94,"type":95},60,"ESTIMATED","OBSERVATIONAL","This research team is doing a study to learn more about a new way to treat long-term knee pain caused by joint damage. They are using a treatment called radiofrequency ablation (RFA). This is a procedure where doctors use heat to stop certain nerves from sending pain signals.\n\nIn this study, doctors will use ultrasound to guide a small needle to nerves around the knee, called genicular nerves. Then, they will apply heat to those nerves using radiofrequency energy to help reduce pain.\n\nThe team created this new method based on recent studies of knee anatomy. They want to find out if this method can safely reduce pain and help people with knee joint damage move better. The study includes people who have moderate to severe knee damage and still have pain after trying medicine, physical therapy, or joint injections.\n\nEach person in the study will have the treatment once. The research team will follow each person for two years. During this time, people in the study will answer simple questions about their knee pain and how it affects their daily life. The researchers will collect this information before the treatment and several times after it. One week after the procedure, the team will call each person to ask how they are feeling and check for any side effects.\n\nPossible benefits of the study include less knee pain and easier movement. Possible risks include pain during the procedure, bruising, swelling, or short-term worsening of pain. Rare risks include nerve problems, weakness, bone damage, or allergic reaction.\n\nThe study is free for participants, and there is no payment. Taking part is voluntary. Anyone can stop being in the study at any time without affecting their medical care. The research team will keep all personal information private and secure.",[99],"Osteoarthritis Knee Pain",[101,102,103,104,105,106,107,108,109,110,111,112,113,114],"Genicular nerve","Knee pain","Chronic pain","Knee osteoarthritis","Radiofrequency ablation","Ultrasound guidance","Interventional pain management","Joint degeneration","Nerve ablation","Image-guided procedures","Non-surgical treatment","Musculoskeletal intervention","Pain reduction","Functional improvement","2025-04-22",{"date":117,"type":118},"2025-04-24","ACTUAL",{"date":120,"type":118},"2025-03-20",{"date":122,"type":95},"2031-07-30",{"name":5,"class":6},2]