[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100519431":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":10,"centralContacts":21,"locations":27,"responsibleParty":43,"collaborators":45,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":10,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":10,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Universitaire Ziekenhuizen KU Leuven","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"with AP",null,[12],"Other: revitalization",{"label":14,"type":10,"description":10,"interventionNames":15},"without AP",[12],[17],{"type":6,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"revitalization","The main idea behind revitalization is to firstly disinfect the root canal and subsequently attract or transplant mesenchymal stem cells from the (remaining) dental pulp and apical papilla (in case of immature permanent teeth) into the root canal. More specifically, this therapy is not based on mechanical and (aggressive) chemical debridement as in conventional root canal treatment but is supported by the pillars of tissue engineering: stem cells, growth factors and a scaffold .",[9,14],[22],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":26},"Nastaran Meschi, MSc, PhD","CONTACT","+32476313889","nastaran.meschi@ugent.be",[28],{"facility":29,"status":30,"city":31,"state":10,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Ghent University","RECRUITING","Ghent","9000","Belgium","BE",{"type":36,"coordinates":37},"Point",[38,39],3.71667,51.05,{"lat":39,"lon":38},[42],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":26},{"type":44,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[46,48,50,52],{"name":47,"class":6},"University Ghent",{"name":49,"class":6},"University of Erlangen-Nürnberg",{"name":51,"class":6},"University of Regensburg",{"name":53,"class":6},"University of Coimbra","100519431","revitalization-of-traumatized-immature-permanent-teeth-100519431",false,"NCT06043453","Revitalization of Traumatized Immature Permanent Teeth","Revitalization of Immature Permanent Teeth With or Without Apical Periodontitis Post Trauma: a European Multicenter Cohort Study","Inclusion Criteria:\n\n* Provision of Informed Consent\n* Female and male patients\n* Age range: 6-18 years\n* \"Healthy\": ASA I and II\n* Permanent immature tooth (Cvek stage of root maturation ≤ 2) requiring revitalization\n* Etiological factor: (a)symptomatic apical periodontitis post dental trauma or irreversible pulpitis post dental trauma\n\nExclusion Criteria:\n\n* Unlikely to be able to comply with the study procedures, as judged by the investigator\n* Patients older than 18 years and younger than 6\n* Deciduous teeth\n* Cvek root maturation stage \\> 2: permanent immature tooth that can be treated by conventional root canal treatment or apexification\n* Known or suspected current malignancy\n* History of chemotherapy within 5 years prior to study\n* History of radiation in the head and neck region\n* History of other metabolic bone diseases\n* Bleeding disorders\n* Involvement in the planning and conduct of the study",true,"ALL","6 Years","18 Years",{"count":66,"type":67},72,"ESTIMATED","OBSERVATIONAL","This study aims to assess the hypothesis that revitalization of teeth without (a)symptomatic apical periodontitis have a more favourable outcome in terms of further root development, periapical bone healing, maintaining\u002Fregaining pulp sensitivity and survival, than teeth with (a)symptomatic apical periodontitis.",[71,72],"Apical Periodontitis","Trauma","2024-06-28",{"date":75,"type":76},"2024-07-01","ACTUAL",{"date":78,"type":76},"2023-10-01",{"date":80,"type":67},"2030-09-01",{"name":5,"class":6},1]