[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100582867":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":28,"locations":34,"responsibleParty":50,"collaborators":10,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":10,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":10,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Chang Gung Memorial Hospital","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"ESRD",null,"ESRD patients under hemodialysis",[13,14],"Other: Blood collection","Other: Cardiopulmonary exercise testing (CPET)",{"label":16,"type":10,"description":17,"interventionNames":18},"Health control","Healthy sedentary volunteers",[13,14],[20,24],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"Blood collection","Erythrocyte osmotic deformability was evaluated via osmotic gradient ektacytometry.",[9,16],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"Cardiopulmonary exercise testing (CPET)","Cardiopulmonary Exercise Testing (CPET) is a non-invasive assessment that evaluates the integrated function of the cardiovascular, pulmonary, and muscular systems during exercise.",[9,16],[29],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Jong-Shyan Wang, PhD","CONTACT","+886-3-2118800 Ext. 5748","s5492@mail.cgu.edu.tw",[35],{"facility":36,"status":37,"city":38,"state":10,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Chang Gung University","RECRUITING","Taoyuan","333","Taiwan","TW",{"type":43,"coordinates":44},"Point",[45,46],121.29696,24.99368,{"lat":46,"lon":45},[49],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Jong-Shyan Wang","Professor","100582867","rheological-functions-of-erythrocyte-in-esrd-100582867",false,"NCT06868888","Rheological Functions of Erythrocyte in ESRD","The Effect of Osmotic Stress in Erythrocyte Rheology in ESRD Patients","Inclusion Criteria:\n\n* Receiving hemodialysis and medication at least for 6 weeks\n* Kt\u002FV score \\> 1.2\n\nExclusion Criteria:\n\n* Under 20 years-old\n* Hyperkalemia occurs within 3 month\n* Having orthopedic or muscular diseases\n* Other concerned medical, psychological or physiological diseases\n* Pregnancy\n* Other exercise contraindications",true,"ALL","20 Years",{"count":65,"type":66},40,"ESTIMATED","OBSERVATIONAL","End-stage renal disease (ESRD) disrupts erythrocyte deformability due to osmotic imbalances, oxidative stress, and uremic toxins, leading to impaired microcirculation and oxygen transport. Dysregulation of ion channels, particularly the Gardos channel, exacerbates dehydration and eryptosis, further compromising vascular integrity. Given the critical role of erythrocyte flexibility in oxygen delivery, this study investigates its relationship with aerobic capacity in ESRD patients, highlighting potential mechanisms of microvascular dysfunction",[70],"End-stage Renal Disease (ESRD)",[72,73,74,75],"Hemodialysis","Aerobic capacity","Deformability","Erythrocyte","2025-03-05",{"date":78,"type":79},"2025-03-11","ACTUAL",{"date":81,"type":79},"2022-08-24",{"date":83,"type":66},"2025-03-26",{"name":5,"class":6},1]