[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596154":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":39,"responsibleParty":51,"collaborators":25,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":25,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":41,"whyStopped":25,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Rhomboid Intercostal Block with Sub-Serratus Plane Block","EXPERIMENTAL","Participants in this group will receive ultrasound-guided Rhomboid Intercostal Block (20 mL of 0.25% bupivacaine between rhomboid major and intercostal space) followed by Sub-Serratus Plane Block (20 mL of 0.25% bupivacaine between serratus anterior and ribs) 30-45 minutes before general anesthesia for Modified Radical Mastectomy.",[13],"Procedure: Rhomboid Intercostal Block with Sub-Serratus Plane Block",{"label":15,"type":16,"description":17,"interventionNames":18},"Erector Spinae Plane Block","ACTIVE_COMPARATOR","Participants in this group will receive an ultrasound-guided Erector Spinae Plane Block with 30 mL of 0.25% bupivacaine injected into the paraspinal plane at the T4-T5 level, 30-45 minutes prior to general anesthesia for Modified Radical Mastectomy.",[19],"Procedure: Erector Spinae Plane Block",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Ultrasound-guided regional anesthesia combining two injections:\n\nRhomboid Intercostal Block (20 mL of 0.25% bupivacaine injected between rhomboid major and intercostal space)\n\nSub-Serratus Plane Block (20 mL of 0.25% bupivacaine injected between serratus anterior and ribs).\n\nBoth performed 30-45 minutes before Modified Radical Mastectomy under general anesthesia.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Ultrasound-guided regional block with 30 mL of 0.25% bupivacaine injected into the paraspinal plane at the T4-T5 level, between the erector spinae muscle and the transverse processes.\n\nPerformed 30-45 minutes prior to general anesthesia for Modified Radical Mastectomy.",[15],[30],{"name":31,"affiliation":32,"role":33},"Sayed Mahmoud M Abed, MD","National Cancer Institute - Cairo University","PRINCIPAL_INVESTIGATOR",[35],{"name":31,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","+20 122 680 6532","sayed.abed@nci.cu.edu.eg",[40],{"facility":32,"status":41,"city":42,"state":25,"zip":25,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":25},"RECRUITING","Cairo","Egypt","EG",{"type":46,"coordinates":47},"Point",[48,49],31.24967,30.06263,{"lat":49,"lon":48},{"type":33,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Sayed Mahmoud Abed","assistant professor","100596154","rhomboid-intercostal-block-with-sub-serratus-plane-block-versus-erector-spinae-block-100596154",false,"NCT07041762","Rhomboid Intercostal Block With Sub-Serratus Plane Block Versus Erector Spinae Block","Analgesic Efficacy of Rhomboid Intercostal Block With Sub-Serratus Plane Block Versus Erector Spinae Block in Breast Cancer Surgery","RISS-ESPB","Inclusion Criteria:\n\n* Female breast cancer patients undergoing Modified Radical Mastectomy (MRM)\n\nASA physical status II or III\n\nAge between 18 and 65 years\n\nBody Mass Index (BMI) \\> 20 kg\u002Fm² and \\\u003C 35 kg\u002Fm²\n\nExclusion Criteria:\n\n* Patient refusal\n\nASA physical status IV\n\nAge \\\u003C18 years or \\>65 years\n\nBMI \\\u003C 20 kg\u002Fm² or \\> 35 kg\u002Fm²\n\nKnown allergy or contraindication to local anesthetics or opioids\n\nHistory of psychological disorders or chronic pain\n\nContraindications to regional anesthesia (e.g., coagulopathy, local infection, peripheral neuropathy)\n\nSevere respiratory, cardiac, hepatic, or renal disease","FEMALE","18 Years","65 Years",{"count":66,"type":67},80,"ESTIMATED","INTERVENTIONAL",[70],"NA","This study compares two nerve block techniques-Rhomboid Intercostal with Sub-Serratus Plane Block versus Erector Spinae Plane Block-for pain relief after breast cancer surgery. It aims to determine which method provides better postoperative pain control, reduces opioid use, and improves recovery in patients undergoing modified radical mastectomy at the National Cancer Institute, Cairo University.",[73],"Breast Cancer Patients",[75],"erector spinae block","2025-06-25",{"date":78,"type":79},"2025-06-27","ACTUAL",{"date":81,"type":79},"2025-06-01",{"date":83,"type":67},"2026-07-01",{"name":5,"class":6},1]