[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642045":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":30,"responsibleParty":49,"collaborators":20,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":20,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":78,"whyStopped":20,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"McMaster University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Medication state","EXPERIMENTAL","Participants will have to attend two sessions scheduled approximately one week apart. During one session, participants will be tested while On medication (levodopa). During the other session, participants will be asked to withhold their medication for 12 hours prior to the experimental session. The order of the sessions will be randomized across participants.",[13],"Drug: Withholding Levodopa",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","Withholding Levodopa","Participants will have to withhold Levodopa medication 12 h before one of two experimental sessions.",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Jonathan Cannon, Dr","CONTACT","(905) 531-6902","cannoj9@mcmaster.ca",{"name":28,"role":24,"phone":20,"phoneExt":20,"email":29},"Itzamna Sanchez Moncada, Dr","sanchei@mcmaster.ca",[31],{"facility":32,"status":20,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Psychology Building","Hamilton","Ontario","L8S 4L8","Canada","CA",{"type":39,"coordinates":40},"Point",[41,42],-79.84963,43.25011,{"lat":42,"lon":41},[45,47],{"name":23,"role":24,"phone":46,"phoneExt":20,"email":26},"9055259140",{"name":28,"role":24,"phone":48,"phoneExt":20,"email":29},"3653572844",{"type":50,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100642045","rhythm-psychophysics-with-parkinsons-patients-100642045",false,"NCT07647913","Rhythm Psychophysics With Parkinson's Patients","RPPD","Inclusion Criteria:\n\n* Parkinson's Disease diagnostic\n* Stage 1 or 2 Hoenh-Yahr scale\n* Taking immediate-release Levodopa\n* MoCA score of 26 or above\n\nExclusion Criteria:\n\n* Dementia\n* Other neurodegenerative disease\n* History of substance abuse\n* History of hearing disorders\n* History of neuropsychiatric disease","ALL","40 Years","80 Years",{"count":62,"type":63},34,"ESTIMATED","INTERVENTIONAL",[66],"NA","The goal of this interventional study is to understand how the rhythmic abilities of individuals in the early stages of Parkinson's Disease (PD) are impacted by their levels of dopamine. The main questions it aims to answer are:\n\n* Does dopamine shelter the ability to generate and maintain a regular tapping rhythm in the presence of disrupting sensory information?\n* Does dopamine allow the adaptation of tapping speed in the presence of changing sensory information?\n* Is the engagement of the motor system useful to improve the detection of changes in the tempo of sensory information?\n\nParticipants will be asked to perform a battery of simple rhythmic tasks On and Off medication to evaluate the effect of dopamine on their rhythmic skills.",[69],"Parkinson Disease(PD)",[71,72,73,74,75,76,77],"Parkinson Disease","PD","Rhythm","Sensorymotor synchronization","Perceptual timing","Motor timing","Interval timing","NOT_YET_RECRUITING","2026-06-09",{"date":81,"type":82},"2026-06-15","ACTUAL",{"date":84,"type":63},"2026-09-01",{"date":86,"type":63},"2027-10-31",{"name":5,"class":6},1]