[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100516269":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":33,"centralContacts":38,"locations":43,"responsibleParty":230,"collaborators":233,"id":236,"slug":237,"hasResults":238,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":242,"eligibilityCriteria":243,"healthyVolunteers":238,"sex":244,"minAge":245,"maxAge":246,"enrollmentInfo":247,"targetDuration":250,"studyType":251,"phases":10,"briefSummary":252,"conditions":253,"keywords":10,"overallStatus":257,"whyStopped":10,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":259,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":267},{"fullName":5,"class":6},"University of Siena","OTHER",[8,15,19],{"label":9,"type":10,"description":11,"interventionNames":12},"HFpEF",null,"The HFpEF group includes patients with signs and\u002For symptoms of heart failure and LVEF \\> 50% and objective evidence of structural and\u002For functional cardiac abnormalities consistent with the presence of LV diastolic dysfunction\u002Fraised LV filling pressures, including raised natriuretic peptides.",[13,14],"Diagnostic Test: Echocardiography","Diagnostic Test: Laboratory Test",{"label":16,"type":10,"description":17,"interventionNames":18},"HFmrEF","The HFmrEF group includes patients with signs and\u002For symptoms of heart failure and LVEF 41-49%.",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"HFrEF","The HFrEF group includes patients with signs and\u002For symptoms of heart failure and LVEF \\\u003C 40%.",[13,14],[24,29],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"DIAGNOSTIC_TEST","Echocardiography","Patients will undergo echocardiographic examination. The ejection fraction will be calculated using Simpson's method. The E\u002Fe' ratio will be measured using the Doppler method. E\u002Fe' \\> 13 will be considered an expression of the increase in LVFP. TAPSE will be measured together with the peak tricuspid regurgitation velocity (TVR). Pulmonary arterial hypertension will be defined as TVR \\> 2.8 m\u002Fs. Estimation of right atrial pressure (eRAP) will be obtained based on the diameter and inspiratory collapsibility of the inferior vena cava.",[16,9,20],{"type":25,"name":30,"description":31,"armGroupLabels":32,"otherNames":10},"Laboratory Test","BNP, NT-proBNP and renal function.",[16,9,20],[34],{"name":35,"affiliation":36,"role":37},"Alberto Palazzuoli, MD","Unità di Malattie Cardiovascolari, Dipartimento Cardio-Toraco-Vascolare AOUS, Siena","STUDY_DIRECTOR",[39],{"name":35,"role":40,"phone":41,"phoneExt":10,"email":42},"CONTACT","+390577585363","palazzuoli2@unisi.it",[44,63,78,92,106,119,132,141,151,165,179,193,207,218],{"facility":45,"status":10,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Centro Cardiologico Monzino","Milan","Milano","20138","Italy","IT",{"type":52,"coordinates":53},"Point",[54,55],9.18951,45.46427,{"lat":55,"lon":54},[58,61],{"name":59,"role":40,"phone":10,"phoneExt":10,"email":60},"Pier Giuseppe Agostoni, MD","piergiuseppe.agostoni@unimi.it",{"name":59,"role":62,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"facility":64,"status":10,"city":65,"state":66,"zip":67,"country":49,"countryCode":50,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Department of Medicine, Surgery and Dentistry, Università di Salerno","Fisciano","Salerno","84084",{"type":52,"coordinates":69},[70,71],14.79454,40.77175,{"lat":71,"lon":70},[74,77],{"name":75,"role":40,"phone":10,"phoneExt":10,"email":76},"Michele Ciccarelli, MD","mciccarelli@unisa.it",{"name":75,"role":62,"phone":10,"phoneExt":10,"email":10},{"facility":79,"status":10,"city":80,"state":10,"zip":81,"country":49,"countryCode":50,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"SC Universitaria di Cardiologia - UTIC Policlinico Riuniti Foggia","Foggia","71121",{"type":52,"coordinates":83},[84,85],15.55188,41.45845,{"lat":85,"lon":84},[88,91],{"name":89,"role":40,"phone":10,"phoneExt":10,"email":90},"Michele Correale, MD","michele.correale@libero.it",{"name":89,"role":62,"phone":10,"phoneExt":10,"email":10},{"facility":93,"status":10,"city":94,"state":10,"zip":95,"country":49,"countryCode":50,"cosmosGeoPoint":96,"geoPoint":100,"contacts":101},"Department of Clinical and Experimental Medicine, Operativee Unit of Cardiology, University of Messina","Messina","98125",{"type":52,"coordinates":97},[98,99],15.55256,38.19394,{"lat":99,"lon":98},[102,105],{"name":103,"role":40,"phone":10,"phoneExt":10,"email":104},"Giuseppe Dattilo, MD","dattimed@hotmail.it",{"name":103,"role":62,"phone":10,"phoneExt":10,"email":10},{"facility":107,"status":10,"city":46,"state":10,"zip":108,"country":49,"countryCode":50,"cosmosGeoPoint":109,"geoPoint":113,"contacts":114},"Ospedale Sant'Agostino Milano","20127",{"type":52,"coordinates":110},[111,112],12.59836,42.78235,{"lat":112,"lon":111},[115,118],{"name":116,"role":40,"phone":10,"phoneExt":10,"email":117},"Frank Dini, MD","franklloyddini@gmail.com",{"name":116,"role":62,"phone":10,"phoneExt":10,"email":10},{"facility":120,"status":10,"city":121,"state":10,"zip":122,"country":49,"countryCode":50,"cosmosGeoPoint":123,"geoPoint":127,"contacts":128},"Department of Translational Medical Sciences, CIRCET","Naples","80131",{"type":52,"coordinates":124},[125,126],14.26811,40.85216,{"lat":126,"lon":125},[129,131],{"name":130,"role":40,"phone":10,"phoneExt":10,"email":10},"Gabriele Tocchetti, MD",{"name":130,"role":62,"phone":10,"phoneExt":10,"email":10},{"facility":133,"status":10,"city":121,"state":10,"zip":122,"country":49,"countryCode":50,"cosmosGeoPoint":134,"geoPoint":136,"contacts":137},"Department of Translational Medical Sciences, Federico II University, CIRCET",{"type":52,"coordinates":135},[125,126],{"lat":126,"lon":125},[138,140],{"name":139,"role":40,"phone":10,"phoneExt":10,"email":10},"Valentina Mercurio, MD",{"name":139,"role":62,"phone":10,"phoneExt":10,"email":10},{"facility":142,"status":10,"city":121,"state":10,"zip":122,"country":49,"countryCode":50,"cosmosGeoPoint":143,"geoPoint":145,"contacts":146},"Heart Failure Unit, Department of Cardiology, AORN dei Colli-Monaldi",{"type":52,"coordinates":144},[125,126],{"lat":126,"lon":125},[147,150],{"name":148,"role":40,"phone":10,"phoneExt":10,"email":149},"Daniele Masarone, MD","danielemasarone@gmail.com",{"name":148,"role":62,"phone":10,"phoneExt":10,"email":10},{"facility":152,"status":10,"city":153,"state":10,"zip":154,"country":49,"countryCode":50,"cosmosGeoPoint":155,"geoPoint":159,"contacts":160},"Fondazione IRCCS Policlinico San Matteo - Pavia UOC Cardiologia 1","Pavia","27100",{"type":52,"coordinates":156},[157,158],9.15917,45.19205,{"lat":158,"lon":157},[161,164],{"name":162,"role":40,"phone":10,"phoneExt":10,"email":163},"Stefano Ghio, MD","s.ghio@smatteo.pv.it",{"name":162,"role":62,"phone":10,"phoneExt":10,"email":10},{"facility":166,"status":10,"city":167,"state":10,"zip":168,"country":49,"countryCode":50,"cosmosGeoPoint":169,"geoPoint":173,"contacts":174},"S. Maria della Misericordia Hospital","Perugia","06100",{"type":52,"coordinates":170},[171,172],12.38878,43.1122,{"lat":172,"lon":171},[175,178],{"name":176,"role":40,"phone":10,"phoneExt":10,"email":177},"Erberto Carluccio, MD","erberto.carluccio@unipg.it",{"name":176,"role":62,"phone":10,"phoneExt":10,"email":10},{"facility":180,"status":10,"city":181,"state":10,"zip":182,"country":49,"countryCode":50,"cosmosGeoPoint":183,"geoPoint":187,"contacts":188},"SC Cardiologia, Azienda Ospedaliera Ospedale San Carlo Potenza","Potenza","85100",{"type":52,"coordinates":184},[185,186],15.80794,40.64175,{"lat":186,"lon":185},[189,192],{"name":190,"role":40,"phone":10,"phoneExt":10,"email":191},"Pietro Mazzeo, MD","pietromazzeo91@tiscali.it",{"name":190,"role":62,"phone":10,"phoneExt":10,"email":10},{"facility":194,"status":10,"city":195,"state":10,"zip":196,"country":49,"countryCode":50,"cosmosGeoPoint":197,"geoPoint":201,"contacts":202},"Cardiology, Department of Clinica, Internal, Anesthesiology and Cardiovascular Scienses, Sapienza.","Roma","00161",{"type":52,"coordinates":198},[199,200],11.10642,44.99364,{"lat":200,"lon":199},[203,206],{"name":204,"role":40,"phone":10,"phoneExt":10,"email":205},"Paolo Severino, MD","paolo.severino@uniroma1.it",{"name":204,"role":62,"phone":10,"phoneExt":10,"email":10},{"facility":208,"status":10,"city":195,"state":10,"zip":196,"country":49,"countryCode":50,"cosmosGeoPoint":209,"geoPoint":211,"contacts":212},"Cardiology, Department of Clinica, Internal, Anesthesiology and Cardiovascular Scienses.",{"type":52,"coordinates":210},[199,200],{"lat":200,"lon":199},[213,216],{"name":214,"role":40,"phone":10,"phoneExt":10,"email":215},"Roberto Badagliaca, MD","roberto.badagliacca@uniroma1.it",{"name":217,"role":62,"phone":10,"phoneExt":10,"email":10},"Roberto Badagliacca, MD",{"facility":219,"status":10,"city":220,"state":10,"zip":221,"country":49,"countryCode":50,"cosmosGeoPoint":222,"geoPoint":226,"contacts":227},"Unità di Malattie Cardiovascolari, Dipartimento Cardio-Toraco-Vascolare AOUS, Università degli Studi, Siena.","Siena","53100",{"type":52,"coordinates":223},[224,225],11.33064,43.31822,{"lat":225,"lon":224},[228,229],{"name":35,"role":40,"phone":10,"phoneExt":10,"email":42},{"name":35,"role":62,"phone":10,"phoneExt":10,"email":10},{"type":62,"investigatorFullName":231,"investigatorTitle":232,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Alberto Palazzuoli MD PhD","Professor",[234],{"name":235,"class":6},"Italian Society of Cardiology","100516269","right-ventricular-dysfunction-in-chronic-heart-failure-100516269",false,"NCT06002321","Right Ventricular Dysfunction in Chronic Heart Failure","Right Ventricular Dysfunction in Chronic Heart Failure: Clinical Laboratory and Echocardiographic Characteristics","RIVED-CHF","Inclusion Criteria:\n\n* All patients with a diagnosis of chronic heart failure made according to the recommendations of the ESC guidelines through the simultaneous presence of signs and symptoms of disease associated with BNP and NT proBNP levels \\> 100 and 300 pg\u002Fml respectively which are associated with a modest increase PAPS \\> 30 mmHg with or without right ventricular dilatation.\n\nExclusion Criteria:\n\n* Patients with dyspnea of non-cardiogenic origin, related to systemic respiratory diseases, pulmonary embolism, patients with primary pulmonary hypertension will be excluded.\n* Patients with heart failure linked to primary valvular pathologies or infiltrative pathologies, secondary and on a genetic basis, patients diagnosed with acute heart failure in non-optimized therapy for at least 3 months will also be excluded. - Patients with systemic inflammatory neoplastic diseases, advanced liver and kidney diseases awaiting transplantation will be excluded.","ALL","18 Years","90 Years",{"count":248,"type":249},1000,"ESTIMATED","36 Months","OBSERVATIONAL","The goal of this multi center observational prospective study is to analyze the concordance between the signs and symptoms of RHF and echocardiographic features of RVD in patient with heart failure. The main questions it aims to answer are:\n\n1. to assess the incidence of RVH and RVD in each HF subtypes.\n2. to evaluate prognostic impact ( in terms of cardiovascular mortality and HF hospitalization) of different RVD patterns during a mean followup period of 3 years\n3. To investigate the incidence of different RV maladaptation ( isolated RV dilatation, isolated Pulmonary hypertension, combined pattern) in each HF groups and the related outcome.\n\nParticipants will follow by direct check up visit and\u002For virtual visits every 6 months for a mean follow-up period of 3 years.",[254,255,256],"Chronic Heart Failure","Right Ventricular Dysfunction","Right Heart Failure","NOT_YET_RECRUITING","2023-08-18",{"date":260,"type":261},"2023-08-21","ACTUAL",{"date":263,"type":249},"2023-09-01",{"date":265,"type":249},"2026-09-01",{"name":5,"class":6},14]