[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634279":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":19,"locations":29,"responsibleParty":45,"collaborators":10,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":49,"sex":55,"minAge":56,"maxAge":10,"enrollmentInfo":57,"targetDuration":10,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"CHU de Reims","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Critically Ill Patients Receiving Fluid Loading",null,"The study group consists of adult critically ill patients admitted to the intensive care unit who undergo fluid loading as part of routine clinical care, at the discretion of the attending physician. All patients are prospectively and consecutively included in a single observational cohort. Echocardiographic assessment of right ventricular function, right ventriculo-arterial coupling, and venous congestion parameters is performed before and after fluid administration. The group will be analyzed as a whole, with secondary analyses stratifying patients according to fluid responsiveness or presence of venous congestion. This cohort reflects standard clinical practice in critically ill patients with acute circulatory failure.",[13],"Other: Echography",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Echography","Fluid loading administered according to standard clinical practice at the discretion of the treating physician. Echocardiographic assessment of right ventricular function and venous congestion is performed before and after fluid administration. No experimental treatment is applied.",[9],[20,26],{"name":21,"role":22,"phone":23,"phoneExt":24,"email":25},"Morgan CAPLAN","CONTACT","03 10 73 60 22","0033","mcaplan@chu-reims.fr",{"name":27,"role":22,"phone":10,"phoneExt":10,"email":28},"Guillaume THERY","gthery@chu-reims.fr",[30],{"facility":31,"status":32,"city":33,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Marie Muller","RECRUITING","Reims","France","FR",{"type":37,"coordinates":38},"Point",[39,40],4.02853,49.26526,{"lat":40,"lon":39},[43,44],{"name":21,"role":22,"phone":23,"phoneExt":24,"email":25},{"name":27,"role":22,"phone":10,"phoneExt":10,"email":28},{"type":46,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100634279","right-ventriculo-arterial-coupling-during-fluid-loading-in-icu-patients-100634279",false,"NCT07537621","Right Ventriculo-Arterial Coupling During Fluid Loading in ICU Patients","Prospective Observational Study of Right Ventriculo-arterial Coupling Changes During Fluid Loading and Their Relationship With Congestion Parameters in Critically Ill Adults","RVPA-FLICU","Inclusion criteria:\n\n* Critically ill hospitalized patients\n* Age ≥ 18 years\n* Patients undergoing fluid loading at the discretion of the attending physician, following prediction of fluid responsiveness using any recommended maneuver or dynamic parameter, in the setting of acute circulatory failure requiring vasopressor support and\u002For mean arterial pressure \\\u003C 65 mmHg (or a decrease of ≥ 30 mmHg from baseline in patients with chronic hypertension), and\u002For other signs of hemodynamic instability (tachycardia, mottling, oliguria, hyperlactatemia)\n* Affiliated with a national health insurance system\n\nExclusion criteria :\n\n* Formal refusal from the patient or legally representative after information\n* Patients transferred from another intensive care unit\n* Pregnant or postpartum patients\n* Acute respiratory distress (defined as respiratory rate ≥ 35 breaths\u002Fmin and\u002For signs of increased work of breathing)\n* Ongoing acute coronary syndrome\n* Acute or pulmonale (defined by right ventricular dilation associated with paradoxical septal motion related to an abrupt increase in right ventricular afterload)\n* Primary pulmonary arterial hypertension\n* Intra-abdominal hypertension (intravesical pressure \\> 15 mmHg)\n* Poor echogenicity precluding adequate echocardiographic assessment of the right ventricle\n* Severe valvular heart disease or early postoperative period following valvular surgery","ALL","18 Years",{"count":58,"type":59},100,"ESTIMATED","OBSERVATIONAL","Preload responsiveness and venous congestion have largely been investigated independently in recent literature. However, recent data report a similar incidence of venous congestion regardless of fluid responsiveness status, challenging the concept of a linear continuum between preload independence and fluid intolerance. These findings support the need for a more individualized hemodynamic management strategy that takes venous congestion risk into account.\n\nThe right ventricle plays a central role in this framework. Its function is to maintain an adequate venous return pressure gradient to ensure cardiac output while limiting upstream venous congestion, under strong dependence on its afterload. In physiological conditions, the right ventricle adapts to changes in afterload by increasing contractility to preserve right ventriculo-arterial coupling and optimize its performance.\n\nIn chronic cardiopulmonary diseases, right ventriculo-arterial uncoupling is a well-established prognostic factor, including the presence of occult uncoupling revealed by fluid loading. In critically ill patients, right ventricular systolic dysfunction associated with venous congestion-defining right heart failure-is strongly associated with increased mortality, as is right ventriculo-arterial uncoupling itself.\n\nTo support the concept of fluid tolerance, the investigators hypothesize that impairment of right ventriculo-arterial coupling may exist or occur during fluid loading in critically ill patients, independently of preload responsiveness, and may be associated with worsening upstream venous congestion.",[63,64,65],"Shock","Right Ventricular Dysfunction","Venous Congestion",[67,68,69,70,71],"Right ventriculo-arterial coupling","Fluid loading","Venous congestion","VEXUS score","Critical care echocardiography","2026-06-09",{"date":74,"type":75},"2026-06-10","ACTUAL",{"date":77,"type":75},"2026-06-03",{"date":79,"type":59},"2029-06-04",{"name":5,"class":6},1]