[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100548075":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":10,"responsibleParty":18,"collaborators":21,"id":27,"slug":28,"hasResults":29,"nctId":30,"briefTitle":31,"officialTitle":32,"acronym":33,"eligibilityCriteria":34,"healthyVolunteers":35,"sex":36,"minAge":37,"maxAge":10,"enrollmentInfo":38,"targetDuration":10,"studyType":41,"phases":10,"briefSummary":42,"conditions":43,"keywords":53,"overallStatus":58,"whyStopped":10,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":10},{"fullName":5,"class":6},"University of Haifa","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Clalit Health Services",null,"Individuals over the age of 40 attending to the Clalit HMO clinics in the North of Israel for regular blood tests.",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Geffen Kleinstern","CONTACT","+972545715624","gkleinste@univ.haifa.ac.il",{"type":19,"investigatorFullName":14,"investigatorTitle":20,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Senior Lecturer",[22,24],{"name":23,"class":6},"Clalit Health Services, Haifa and West Galilee",{"name":25,"class":26},"Bnai Zion Medical Center","OTHER_GOV","100548075","risk-and-clinical-consequences-of-low-count-monoclonal-b-cell-lymphocytosis-lc-mbl-100548075",false,"NCT06416267","Risk and Clinical Consequences of Low Count Monoclonal B-cell Lymphocytosis (LC MBL)","Immune Biomarkers, Genetic Risk, and the Clinical Consequences of Low Count Monoclonal B-cell Lymphocytosis (LC MBL)","MBL RiskConseq","Inclusion Criteria:\n\n* Individuals over the age pf 40\n\nExclusion Criteria:\n\n* Individuals with lymphoproliferative disorder",true,"ALL","40 Years",{"count":39,"type":40},1500,"ESTIMATED","OBSERVATIONAL","The aim of this proposal is to identify immune biomarkers, genetic risk, and the clinical consequences of low count monoclonal B-cell lymphocytosis (LC MBL), a common premalignant condition affecting up to 17% of European adults age\\>40. LC MBL is a precursor to chronic lymphocytic leukemia (CLL), characterized by a circulating population of clonal B-cells. It is relatively understudied, despite emerging evidence of clinical consequences such as increased risk for life-threatening infections and lymphoid malignancies. Studies reported that male sex, age, family history of CLL, and CLL-susceptibility genetic loci were associated with LC MBL risk. These findings were reported in European ancestry individuals and have not been generalized to other thnicities. This study will provide this missing knowledge using a unique multi-ethnic Israeli population of Jews and Arabs that have one of the highest and lowest age-standardized incidence rates of CLL in the world, respectively, and characterized with different genetic backgrounds.",[44,45,46,47,48,49,50,51,52],"Monoclonal B-Cell Lymphocytosis","Chronic Lymphocytic Leukemia","Infections","Cancers","Cardiovascular Diseases","Alzheimer Disease","Dementia","Autoimmune Diseases","Parkinson Disease",[54,55,56,46,47,57],"Monoclonal B cell Lymphocytosis","Genetic Risk","Outcomes","CLL","NOT_YET_RECRUITING","2024-05-10",{"date":61,"type":62},"2024-05-16","ACTUAL",{"date":64,"type":40},"2024-08",{"date":66,"type":40},"2040-12",{"name":5,"class":6}]