[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577090":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":26,"responsibleParty":52,"collaborators":10,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":64,"maxAge":10,"enrollmentInfo":65,"targetDuration":68,"studyType":69,"phases":10,"briefSummary":70,"conditions":71,"keywords":75,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Ruijin Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Study cohort",null,"Patients with CCS or NSTE-ACS, who receive CCTA scan showing marginal or obstructive lesions (DS 40%-90%), are then referred to invasive coronary angiography with intracoronary imaging examination, such as IVUS, OCT, NIRS, within 1 month",[13],{"name":14,"affiliation":5,"role":15},"Ruiyan Zhang, M.D., Ph.D.","STUDY_DIRECTOR",[17,23],{"name":18,"role":19,"phone":20,"phoneExt":21,"email":22},"Xiaoqun Wang, M.D., Ph.D.","CONTACT","+86 21 64370045","671605","xiaoqun_wang@hotmail.com",{"name":24,"role":19,"phone":20,"phoneExt":21,"email":25},"Shuo Feng, M.D., Ph.D.","fengshuorv@hotmail.com",[27],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Ruijin Hospital, Shanghai Jiaotong University School of Medicine","RECRUITING","Shanghai","Shanghai Municipality","200025","China","CN",{"type":36,"coordinates":37},"Point",[38,39],121.45806,31.22222,{"lat":39,"lon":38},[42,46,48,50],{"name":43,"role":19,"phone":44,"phoneExt":10,"email":45},"Jian Li, BS","0086 021 64370045","ruijincrc@126.com",{"name":14,"role":47,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"name":18,"role":49,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"name":51,"role":49,"phone":10,"phoneExt":10,"email":10},"Shuo Feng, M.D.,Ph,D,",{"type":47,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"RUIYAN ZHANG","Director of Cardiology, Director of cardiovascular catherization lab, Principle Investigator","100577090","risk-evaluation-by-coronary-imaging-and-artificial-intelligence-based-functional-analyzing-techniques---iii-100577090",false,"NCT06793774","Risk Evaluation by COronary Imaging and Artificial intelliGence Based fuNctIonal analyZing tEchniques - III","Risk Evaluation by Coronary Imaging and Artificial Intelligence-Based Functional Analyzing Techniques: Integrated Plaque Analysis by Coronary CT Angiography and Intracoronary Imaging.","RECOGNIZE-III","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Patients with CCS or NSTE-ACS\n* Receive CCTA scan, with marginal lesions (DS between 40%-69%) or obstructive lesions (DS ≥70% or CT-FFR \\\u003C0.8) in major coronary arteries\n* Receive invasive coronary angiography and intracoronary imaging examination, including IVUS, OCT, NIRS, within 1 month after CCTA\n\nExclusion Criteria:\n\n* Unsuitable for CCTA (such as severe renal impairment, uncontrolled thyroid condition, allergic to iodine, etc.)\n* Receive percutaneous coronary intervention (PCI) within 6 months\n* Prior history of myocardial infarction or heart failure\n* Prior history of coronary artery bypass graft (CABG)\n* Abnormal liver function (serum alanine aminotransferase \\[ALT\\] level exceeding 3 times the upper limit of normal) or abnormal kidney function (eGFR ≤30%)\n* Familial hypercholesterolemia\n* Estimated survival ≤ 1 year\n* Malignant tumor\n* Pregnant or lactation, or have the intention to give birth within one year\n* Poor compliance, unable to follow-up","ALL","18 Years",{"count":66,"type":67},300,"ESTIMATED","2 Years","OBSERVATIONAL","This is a single-center, prospective cohort study. This study is designed to accurately analyze coronary artery plaque characteristics and local hemodynamic parameters in patients diagnosed with chronic coronary syndrome (CCS) or non-ST-segment elevation acute coronary syndrome (NSTE-ACS), with marginal lesions or obstructive lesions in major coronary arteries by multimodality imaging including noninvasive coronary CT angiography (CCTA) and intracoronary imaging techniques, such as intravascular ultrasound (IVUS), optical coherence tomography (OCT), and near infrared spectroscopy (NIRS). The purpose of this study is to improve the accuracy and depth of plaque analysis by CCTA under the guidance of intracoronary imaging, therefore constructing a new CCTA-based high-risk plaque model.",[72,73,74],"Coronary Artery Disease","Coronary Atheroscleroses","Acute Coronary Syndromes (ACS)",[76,77,78],"coronary CT angiography","intracoronary imaging","coronary optical coherence tomography","2025-01-21",{"date":81,"type":82},"2025-01-27","ACTUAL",{"date":84,"type":82},"2024-07-01",{"date":86,"type":67},"2027-12-31",{"name":5,"class":6},1]