[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558962":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":22,"locations":28,"responsibleParty":44,"collaborators":10,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":10,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":56,"studyType":61,"phases":10,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Sohag University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"A:successful extubation",null,"mechanically ventilated PICU patients who pass spontaneous breathing trial and air leak test , extubated and not requiring to be re-intubated within 48 hours.",{"label":13,"type":10,"description":14,"interventionNames":10},"B: failed extubation","mechanically ventilated PICU patients who don't pass spontaneous breathing trial and air leak test , extubated and requiring to be re-intubated within 48 hours.",[16,20],{"name":17,"affiliation":18,"role":19},"Mostafa Ashry Mohamed, assistant professeer","pediatrics department faculty of medicine sohag university","STUDY_DIRECTOR",{"name":21,"affiliation":18,"role":19},"Rania Gamal Mostafa Abdelatif, lecturer",[23],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"mariam raafat helmy, postgraduate","CONTACT","01284134530","mariam.rafaat@med.sohag.edu.eg",[29],{"facility":30,"status":31,"city":32,"state":10,"zip":10,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Sohag University Hospitals","RECRUITING","Sohag","Egypt","EG",{"type":36,"coordinates":37},"Point",[38,39],31.69478,26.55695,{"lat":39,"lon":38},[42],{"name":43,"role":25,"phone":10,"phoneExt":10,"email":10},"Magdy M Amin",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Mariam Rafaat Helmy","postgraduate pediatriacian","100558962","risk-factors-of-extubation-failure-in-picu-patients-100558962",false,"NCT06557941","Risk Factors of Extubation Failure in PICU Patients","The Risk Factors of Extubation Failure in Pediatric Intensive Unite Patients at Sohag University Hospitals","Inclusion Criteria:\n\n* All patient at PICU \\\u003C 18 years subjected to MV through an endotracheal tube at least \\>12 hours.\n* Patients eligible for weaning from MV according to the weaning criteria (Evidence for some reversal of the underlying cause following for respiratory failure, Adequate oxygenation\" PaO2\u002FFIO2 ratio ≥ 200, FIO2 ≤ 0.40, PaO2 ≥ 60, PaCO2 ≤ 60 and PEEP ≤ 5 cmH2O.\", PH ≥ 7.25, Respiratory rate (RR) ≤ 45 bpm, Heart rate (HR) ≤ 140 bpm,(rapid shallow breathing index = tidal volume \u002F RR) RSBI ≤ 8 breaths\u002Fmin\u002Fml\u002Fkg body weight, Hemodynamic stable, no or minimal vasopressor or inotropes\"\\[1,12\\],.\n* Appropriate level of consciousness, No continuous sedation infusion nor neuromuscular blocking agents, afebrile, adequate hemoglobin ≥ 7.5 g\u002Fdl and\u002For no evidence of hemorrhage.\n\nExclusion Criteria:\n\n* Patients less than 30 days.\n* Tracheostomized patients.\n* Death on mv ≤ 12 hours.\n* Unplanned extubation.","ALL","30 Days","18 Years",{"count":59,"type":60},100,"ESTIMATED","OBSERVATIONAL","Up to 20% of MV patients experience EF \\[10\\]. EF is defined as the need to reinsert the endotracheal tube to resume MV in patients extubated for less than 48 hours. It has high rates of morbidity and mortality, prolongs the duration of MV and thus causes a longer stay in the PICU and risk of complications such as the need for tracheostomy, the incidence of pneumonia and pulmonary damage, and finally, costs increase as well and death \\[10, 11\\] .",[64],"Extubation Failure",[66,67,68],"extubation failure","mechanical ventilation","PICU","2024-08-14",{"date":71,"type":72},"2024-08-16","ACTUAL",{"date":74,"type":72},"2024-05-01",{"date":76,"type":60},"2025-05",{"name":5,"class":6},1]