[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621192":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":12,"centralContacts":25,"locations":31,"responsibleParty":43,"collaborators":12,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":12,"eligibilityCriteria":52,"healthyVolunteers":49,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":12,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":70,"overallStatus":78,"whyStopped":12,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Hopital La Rabta","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Outside Ramadan fasting","NO_INTERVENTION","Patients with PAI treated with prednisolone 5mg\u002Fday, outside Ramadan fasting",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Ramadan fasting","EXPERIMENTAL","Patients with PAI treated with prednisolone 5mg\u002Fday during Ramadan fasting.",[18],"Other: Ramadan fasting",[20],{"type":6,"name":14,"description":21,"armGroupLabels":22,"otherNames":23},"Ramadan fasting is a religious dry intermittent fasting",[14],[24],"dry intermittent fasting",[26],{"name":27,"role":28,"phone":29,"phoneExt":12,"email":30},"Melika Chihaoui, Professor","CONTACT","+216 98647327","melika.chihaoui@fmt.utm.tn",[32],{"facility":33,"status":12,"city":34,"state":12,"zip":12,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":12},"University Hospital La Rabta","Tunis","Tunisia","TN",{"type":38,"coordinates":39},"Point",[40,41],10.16579,36.81897,{"lat":41,"lon":40},{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"PRINCIPAL_INVESTIGATOR","Melika Chihaoui","Professor of Endocrinology, Faculty of Medicine of Tunis, University Tunis El Manar. Head of the Department of Endocrinology, University hospital La rabta, Tunis, Tunisia.","100621192","risks-of-ramadan-fasting-in-patients-with-primary-adrenal-insufficiency-treated-with-prednisolone-100621192",false,"NCT07367425","Risks of Ramadan Fasting in Patients With Primary Adrenal Insufficiency Treated With Prednisolone.","Inclusion Criteria:\n\n* subjects with primary adrenal insufficiency known for at least one year, treated with a glucocorticoid and a mineralocorticoid, who wish to fast during Ramadan 2026.\n\nExclusion Criteria:\n\n* presence of diabetes, renal, hepatic, cardiac, or respiratory insufficiency; use of hypoglycemic agents (sulfonylureas), diuretics, use of any glucocorticoid other than the prescribed replacement therapy; poor disease control (asthenia, malaise, hyperpigmentation, discontinuation of treatment, etc.); pregnancy; breastfeeding; menstruation.","ALL","20 Years","70 Years",{"count":57,"type":58},35,"ESTIMATED","INTERVENTIONAL",[61],"NA","In primary adrenal insufficiency (PAI), there is a risk of hypoglycemia and dehydration. These risks seem to be increased during intermittent fasting. A previous study in patients with PAI treated with hydrocortisone at a dose of 20 mg\u002Fday showed that the prevalence of hypoglycemia was as high outside (63%) as during Ramadan fasting (71%), and that there was no risk of dehydration. We propose to evaluate the risk of complications during and outside of Ramadan fasting through a prospective study with subjects taken as their own controls, in 35 patients with PAI treated with prednisolone at a dose of 5 mg\u002Fday. Patients will undergo an interview, physical examination, blood sampling, and continuous glucose monitoring (CGM) during two weeks of fasting and two weeks of non-fasting.",[64,65,66,67,68,69],"Primary Adrenal Insufficiency","Ramadan Fasting","Prednisolone","Continuous Glucose Monitoring","Hypoglycemia Non-Diabetic","Dehydration",[71,14,72,73,74,75,76,77],"primary adrenal insufficiency","continuous glucose monitoring","hypoglycemia","dehydration","glucocorticoid replacement therapy","prednisolone","hypotension","NOT_YET_RECRUITING","2026-01-16",{"date":81,"type":82},"2026-01-26","ACTUAL",{"date":84,"type":58},"2026-01-22",{"date":86,"type":58},"2026-03-30",{"name":5,"class":6},1]