[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634851":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":30,"responsibleParty":43,"collaborators":11,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":11,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":11,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":11,"overallStatus":66,"whyStopped":11,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Shanghai Chest Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with clinically suspected malignant pulmonary nodules requiring diagnosis and treatment","EXPERIMENTAL",null,[13],"Procedure: Robotic-assisted bronchoscopy-guided synchronous biopsy and radiofrequency ablation for pulmonary nodules",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"PROCEDURE","Robotic-assisted bronchoscopy-guided synchronous biopsy and radiofrequency ablation for pulmonary nodules","All procedures are performed under general anesthesia with endotracheal intubation and mechanical ventilation. All procedures are performed under the guidance of shape-sensing robotic-assisted bronchoscopy integrated with mobile cone-beam computed tomography. Cyobiopsy is performed first using the 1.1-mm cryoprobe, followed by intraoperative frozen section for rapid diagnosis. If malignancy is confirmed, radiofrequency ablation is conducted in the same procedure.",[9],[21],{"name":22,"affiliation":5,"role":23},"Jiayuan Sun, MD, PhD","STUDY_DIRECTOR",[25],{"name":22,"role":26,"phone":27,"phoneExt":28,"email":29},"CONTACT","86-021-22200000","1511","xkyyjysun@163.com",[31],{"facility":5,"status":11,"city":32,"state":11,"zip":11,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Shanghai","China","CN",{"type":36,"coordinates":37},"Point",[38,39],121.45806,31.22222,{"lat":39,"lon":38},[42],{"name":22,"role":26,"phone":27,"phoneExt":28,"email":29},{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Jiayuan Sun","Director, Department of Respiratory Endoscopy","100634851","robotic-assisted-bronchoscopy-guided-synchronous-biopsy-and-radiofrequency-ablation-for-pulmonary-nodules-100634851",false,"NCT07545057","Robotic-Assisted Bronchoscopy-Guided Synchronous Biopsy and Radiofrequency Ablation for Pulmonary Nodules","A Feasibility Study on Synchronous Biopsy and Radiofrequency Ablation for Pulmonary Nodules Under Robotic-Assisted Bronchoscopy: A Prospective, Single-Arm, Open-Label Clinical Study：ROBUST Study","Inclusion Criteria:\n\n* Age ≥ 18 years old;\n* Chest CT indicates pulmonary nodules, highly suspected of being malignant;\n* Size of pulmonary nodules: 8 mm \\\u003C maximum diameter ≤ 30 mm, and the number of pulmonary nodules requiring intervention ≤ 3;\n* Preoperative imaging evaluation indicates no clear lymph node metastasis or distant metastasis (cT1N0M0);\n* Multidisciplinary evaluation shows that the patient cannot tolerate surgery and radiotherapy, or the patient refuses surgery and radiotherapy after full informed consent;\n* The patient understands and agrees to receive synchronous biopsy and ablation treatment under robotic-assisted bronchoscopy and signs a written informed consent form.\n\nExclusion Criteria:\n\n* Patients who cannot tolerate general anesthesia due to advanced age or severe cardiopulmonary diseases, or other reasons;\n* The target nodule has been diagnosed as a malignant tumor or metastasis;\n* Patients with severe bleeding tendency or uncorrectable coagulation disorder (platelet count \\\u003C 50×10\\^9 \u002FL, prothrombin time \\> 18s, prothrombin activity \\\u003C 40%);\n* Severe pulmonary fibrosis and pulmonary hypertension;\n* Anticoagulant or anti-platelet drugs have not been discontinued for the required time before surgery;\n* Implanted cardiac pacemaker, defibrillator, or other electronic implants;\n* Presence of important blood vessels that cannot be avoided along the biopsy path;\n* Other conditions that the investigators consider not suitable for the patient to participate in this study.","ALL","18 Years","100 Years",{"count":58,"type":59},76,"ESTIMATED","INTERVENTIONAL",[62],"NA","This is a prospective, single-arm, open-label clinical study. The primary study objective is to evaluate the feasibility of synchronous biopsy and radiofrequency ablation for pulmonary nodules under robotic-assisted bronchoscopy.",[65],"Pulmonary Nodules","NOT_YET_RECRUITING","2026-04-22",{"date":69,"type":70},"2026-04-28","ACTUAL",{"date":72,"type":59},"2026-05-01",{"date":74,"type":59},"2027-12-31",{"name":5,"class":6},1]