[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631449":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":24,"centralContacts":27,"locations":33,"responsibleParty":68,"collaborators":70,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":78,"sex":84,"minAge":24,"maxAge":24,"enrollmentInfo":85,"targetDuration":24,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":95,"overallStatus":36,"whyStopped":24,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"University of Zurich","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Robotic-Assisted Bronchoscopy With Cone-Beam CT Guidance","EXPERIMENTAL","Robotic-assisted bronchoscopy using a shape-sensing robotic platform with cone-beam CT confirmation of biopsy location. Four cryobiopsies will be obtained from two lung lobes using a 1.7 mm cryoprobe.",[13],"Procedure: Robotic-Assisted Bronchoscopy With Cone-Beam CT Guidance",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional Bronchoscopy With Fluoroscopy Guidance","ACTIVE_COMPARATOR","Flexible bronchoscopy with 2D fluoroscopy guidance. Four cryobiopsies will be obtained from two lung lobes using a 1.7 mm cryoprobe.",[19],"Procedure: Conventional Bronchoscopy With Fluoroscopy Guidance",[21,25],{"type":22,"name":9,"description":11,"armGroupLabels":23,"otherNames":24},"PROCEDURE",[9],null,{"type":22,"name":15,"description":17,"armGroupLabels":26,"otherNames":24},[15],[28],{"name":29,"role":30,"phone":31,"phoneExt":24,"email":32},"Thomas Gaisl, MD MPH PhD","CONTACT","+41762318339","thomas.gaisl@uzh.ch",[34,53],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Cantonal Hospital of Lucerne","RECRUITING","Lucerne","Canton of Lucerne","6000","Switzerland","CH",{"type":43,"coordinates":44},"Point",[45,46],8.30635,47.05048,{"lat":46,"lon":45},[49],{"name":50,"role":30,"phone":51,"phoneExt":24,"email":52},"Fiorenza Gautschi, MD","+41 205 22 82","fiorenza.gautschi@luks.ch",{"facility":54,"status":36,"city":55,"state":56,"zip":57,"country":40,"countryCode":41,"cosmosGeoPoint":58,"geoPoint":62,"contacts":63},"University Hospital Zurich","Zurich","Canton of Zurich","8091",{"type":43,"coordinates":59},[60,61],8.55,47.36667,{"lat":61,"lon":60},[64],{"name":65,"role":30,"phone":66,"phoneExt":24,"email":67},"Carolin Steinack, MD","+41442553828","carolin.steinack@usz.ch",{"type":69,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[71,74],{"name":72,"class":73},"Cantonal Hospital of Lucerne, Switzerland","UNKNOWN",{"name":75,"class":6},"University Hospital, Zürich","100631449","robotic-assisted-versus-conventional-bronchoscopy-for-cryobiopsy-in-the-diagnosis-of-interstitial-lung-disease-100631449",false,"NCT07500818","Robotic-Assisted Versus Conventional Bronchoscopy for Cryobiopsy in the Diagnosis of Interstitial Lung Disease","Robotic-Assisted Versus Conventional Bronchoscopy for Cryobiopsy in the Diagnosis of Interstitial Lung Disease: A Randomized Controlled Trial","RAB-ILD-RCT","Inclusion Criteria:\n\n* Age ≥18 years\n* Clinical suspicion of interstitial lung disease requiring histological confirmation\n* Non-diagnostic HRCT pattern (e.g. probable UIP or indeterminate pattern)\n* Candidate for transbronchial lung cryobiopsy\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Definite UIP pattern on HRCT\n* Severe pulmonary hypertension\n* Severe hypoxemia contraindicating bronchoscopy\n* Coagulopathy or contraindication to biopsy\n* Pregnancy\n* Inability to provide informed consent","ALL",{"count":86,"type":87},30,"ESTIMATED","INTERVENTIONAL",[90],"NA","Interstitial lung disease (ILD) often requires histopathological confirmation when high-resolution computed tomography (HRCT) findings are inconclusive. Transbronchial lung cryobiopsy has emerged as a less invasive alternative to surgical lung biopsy, but diagnostic yield remains variable and dependent on biopsy location and procedural precision.\n\nRobotic-assisted bronchoscopy (RAB) combined with cone-beam computed tomography (CBCT) may allow more precise navigation to target lung segments and potentially improve biopsy quality and diagnostic yield.\n\nThis multi-center, investigator-initiated randomized controlled trial will compare conventional bronchoscopy with 2D fluoroscopy guidance versus robotic-assisted bronchoscopy with CBCT guidance for transbronchial lung cryobiopsy in patients undergoing diagnostic evaluation for suspected interstitial lung disease.\n\nParticipants will be randomized in a 1:1 ratio to undergo either conventional bronchoscopy or robotic-assisted bronchoscopy. In both groups, four cryobiopsies will be obtained from two lung lobes using a 1.7 mm cryoprobe (en-bloc removal for both study arms).\n\nThe primary endpoint is the rate of definitive histological diagnosis as determined by a blinded multidisciplinary ILD board.",[93,94],"Interstitial Lung Disease (ILD)","Lung Biopsy",[96,97,98,99,100],"Robotic-assisted Bronchoscopy","Cryobiopsy","CBCT","Interventional Pulmonology","Interstitial Lung Disease","2026-03-24",{"date":103,"type":104},"2026-03-30","ACTUAL",{"date":106,"type":104},"2026-02-01",{"date":108,"type":87},"2027-09-01",{"name":5,"class":6},2]