[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100580606":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":38,"locations":49,"responsibleParty":360,"collaborators":67,"id":362,"slug":363,"hasResults":364,"nctId":365,"briefTitle":366,"officialTitle":367,"acronym":368,"eligibilityCriteria":369,"healthyVolunteers":364,"sex":370,"minAge":371,"maxAge":372,"enrollmentInfo":373,"targetDuration":67,"studyType":376,"phases":377,"briefSummary":379,"conditions":380,"keywords":382,"overallStatus":223,"whyStopped":67,"lastUpdateSubmitDate":390,"lastUpdatePostDateStruct":391,"startDateStruct":394,"completionDateStruct":396,"leadSponsor":398,"locationsCount":399},{"fullName":5,"class":6},"IRCCS San Raffaele Roma","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental Group (EG)","EXPERIMENTAL","Participants assigned to Experimental Group (EG) will follow 18+\u002F-3sessions (from a minimum of 3 times to a maximum of 5 times\u002Fweek) of robotic-assisted treatment for upper limb rehabilitation using the Gloreha Sinfonia (R-Touch Pro; BTL Robotics, USA) robotic device in addition to the standard rehabilitation program.",[13],"Device: Robotic Assisted Upper Limb Rehabilitation",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group (CG)","ACTIVE_COMPARATOR","Participants assigned to Control Group (CG) will follow 18+\u002F-3 sessions (from a minimum of 3 times to a maximum of 5 times\u002Fweek) of conventional tratment for upper limb rehabilitation in addition to the standard rehabilitation program.",[19],"Other: Control Group (CG)",[21,29],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Robotic Assisted Upper Limb Rehabilitation","The EG will follow a mixed rehabilitation approach for the upper limb, combining Robotic Assisted Upper Limb Rehabilitation and conventional physical therapy (PT) and\u002For occupational therapy (OT) with a total daily duration of 90 minutes. The Robotic Assisted UL Rehabilitation's session will last 30 minutes, with the following procedure provided:\n\n* First week: alternate between passive mobilization exercises, bilateral mode, and therapist-driven mode.\n* Second week: alternate between therapist-driven mode and active-assisted mobilization.\n* Third week: alternate between active-assisted mobilization and active mobilization.\n* Fourth week: alternate between active-assisted mobilization and active mobilization.\n* Fifth week: exclusively perform active mobilization. However, if this proposed progression does not match the patient's motor capabilities, the therapist will optimize the therapeutic program by selecting personalized exercises, following a progressive difficulty approach.",[9],[27,28],"Gloreha Simfonia (R-TOUCH)","Robotic treatment for upper limb rehabilitation using the Gloreha Sinfonia (R-Touch)",{"type":6,"name":15,"description":30,"armGroupLabels":31,"otherNames":32},"The CG will follow a conventional occupational therapy (OT) and physical therapy (PT) program for upper limb rehabilitation, with a total daily duration of 90 minutes. Upper limb rehabilitation exercises will be performed with a therapist who will tailor the treatment according to the patient's clinical characteristics and needs. Specifically, upper limb treatment will consist of motor exercises (shoulder, elbow, wrist, and hand) through a mix of individual sessions with both passive and active interventions where possible.",[15],[33],"Conventional treatment for upper limb rehabilitation",[35],{"name":36,"affiliation":5,"role":37},"Sanaz Pournajaf, DPT, PhD","PRINCIPAL_INVESTIGATOR",[39,44],{"name":36,"role":40,"phone":41,"phoneExt":42,"email":43},"CONTACT","+39 0652252405","32405","sanaz.pournajfa@sanraffaele.it",{"name":45,"role":40,"phone":46,"phoneExt":47,"email":48},"Carrie Louise Thouant, OT, MSc","+39 0652252338","32338","carrielouise.thouant@sanraffaele.it",[50,72,87,101,115,128,144,159,174,189,204,210,222,236,250,264,273,290,307,323,341],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Jefferson Moss-Magee Rehabilitation, Department of PMR","NOT_YET_RECRUITING","Elkins Park","Pennsylvania","19027","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-75.12684,40.07706,{"lat":62,"lon":61},[65,69,71],{"name":66,"role":40,"phone":67,"phoneExt":67,"email":68},"Alberto Esquenazi, MD, PhD",null,"alberto.esquenazi@jefferson.edu",{"name":70,"role":40,"phone":67,"phoneExt":67,"email":67},"Alexey Nastaskin, OT",{"name":66,"role":37,"phone":67,"phoneExt":67,"email":67},{"facility":73,"status":52,"city":74,"state":67,"zip":75,"country":76,"countryCode":67,"cosmosGeoPoint":77,"geoPoint":81,"contacts":82},"Rehabilitation Center of Kladruby","Kladruby","257 62","Czechia",{"type":59,"coordinates":78},[79,80],12.98232,49.71498,{"lat":80,"lon":79},[83,86],{"name":84,"role":40,"phone":67,"phoneExt":67,"email":85},"Mgr. Lukas Chobot, PT","lukas.chobot@rehabilitace.cz",{"name":84,"role":37,"phone":67,"phoneExt":67,"email":67},{"facility":88,"status":52,"city":89,"state":67,"zip":90,"country":76,"countryCode":67,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"Lázně Bělohrad a.s., Centrum komplexní rehabilitace","Lázně Bělohrad","50781",{"type":59,"coordinates":92},[93,94],15.58269,50.42874,{"lat":94,"lon":93},[97,100],{"name":98,"role":40,"phone":67,"phoneExt":67,"email":99},"Kateřina Macháčková, MgR, PhD","katerina.machackova@belohrad.cz",{"name":98,"role":37,"phone":67,"phoneExt":67,"email":67},{"facility":102,"status":52,"city":103,"state":67,"zip":104,"country":76,"countryCode":67,"cosmosGeoPoint":105,"geoPoint":109,"contacts":110},"Agel Hospital Prostějov, Rehabilitation Centre, Mathonova 1, Clinical Rehabilitation Centre FZV UP, Hněvotínská 3","Olomouc","77900",{"type":59,"coordinates":106},[107,108],17.25175,49.59552,{"lat":108,"lon":107},[111,114],{"name":112,"role":40,"phone":67,"phoneExt":67,"email":113},"Petr Konečný, MD, PhD","petr.konecny@upol.cz",{"name":112,"role":37,"phone":67,"phoneExt":67,"email":67},{"facility":116,"status":52,"city":117,"state":67,"zip":67,"country":76,"countryCode":67,"cosmosGeoPoint":118,"geoPoint":122,"contacts":123},"Charles University and General University Hospital in Prague","Prague",{"type":59,"coordinates":119},[120,121],14.42076,50.08804,{"lat":121,"lon":120},[124,127],{"name":125,"role":40,"phone":67,"phoneExt":67,"email":126},"Kristýna Hoidekrová, OT, PhD","kristyna.hoidekrova@gmail.com",{"name":125,"role":37,"phone":67,"phoneExt":67,"email":67},{"facility":129,"status":52,"city":130,"state":131,"zip":67,"country":132,"countryCode":133,"cosmosGeoPoint":134,"geoPoint":138,"contacts":139},"European Society of Physical and Rehabilitation Medicine, SISC in New Technologies and Robotics in Rehabilitation","Rome","Choose One...","Italy","IT",{"type":59,"coordinates":135},[136,137],12.51133,41.89193,{"lat":137,"lon":136},[140,143],{"name":141,"role":40,"phone":67,"phoneExt":67,"email":142},"Alessandro Giustini, MD","alessandro.giustini@ntc.it",{"name":141,"role":37,"phone":67,"phoneExt":67,"email":67},{"facility":145,"status":52,"city":146,"state":147,"zip":148,"country":132,"countryCode":133,"cosmosGeoPoint":149,"geoPoint":153,"contacts":154},"San Vito Hospital, Rehabilitation Unit","San Vito sullo Ionio","CZ","88067",{"type":59,"coordinates":150},[151,152],16.40862,38.70749,{"lat":152,"lon":151},[155,158],{"name":156,"role":40,"phone":67,"phoneExt":67,"email":157},"Andrea Parente, MD","parenteandrea3@gmail.com",{"name":156,"role":37,"phone":67,"phoneExt":67,"email":67},{"facility":160,"status":52,"city":161,"state":162,"zip":67,"country":132,"countryCode":133,"cosmosGeoPoint":163,"geoPoint":167,"contacts":168},"Valduce Hospital, Villa Beretta Rehabilitation Center","Costa Masnaga","LC",{"type":59,"coordinates":164},[165,166],9.27632,45.76963,{"lat":166,"lon":165},[169,172],{"name":170,"role":40,"phone":67,"phoneExt":67,"email":171},"Eleonora Guanziroli, Ing. PhD","eleonora.guanziroli@gmail.com",{"name":173,"role":37,"phone":67,"phoneExt":67,"email":67},"Franco Molteni, MD",{"facility":175,"status":52,"city":176,"state":177,"zip":178,"country":132,"countryCode":133,"cosmosGeoPoint":179,"geoPoint":183,"contacts":184},"Department of Rehabilitative Medicine, AUSL Piacenza","Fiorenzuola d'Arda","PC","29017",{"type":59,"coordinates":180},[181,182],9.91329,44.92435,{"lat":182,"lon":181},[185,188],{"name":186,"role":40,"phone":67,"phoneExt":67,"email":187},"Gianfranco Lamberti, MD, PhD","g.lamberti2@ausl.pc.it",{"name":186,"role":37,"phone":67,"phoneExt":67,"email":67},{"facility":190,"status":52,"city":191,"state":192,"zip":193,"country":132,"countryCode":133,"cosmosGeoPoint":194,"geoPoint":198,"contacts":199},"Passignano Hospital, Department of Specialized Medicine, Usl Umbria 1","Passignano sul Trasimeno","Perugia","06065",{"type":59,"coordinates":195},[196,197],12.13535,43.19043,{"lat":197,"lon":196},[200,203],{"name":201,"role":40,"phone":67,"phoneExt":67,"email":202},"Maurizio Massucci, MD, PhD","maurizio.massucci@gmail.com",{"name":201,"role":37,"phone":67,"phoneExt":67,"email":67},{"facility":205,"status":206,"city":207,"state":208,"zip":209,"country":132,"countryCode":133,"cosmosGeoPoint":67,"geoPoint":67,"contacts":67},"Istituto Clinico Tiberino","ENROLLING_BY_INVITATION","Ummbertide","PG","06019",{"facility":211,"status":52,"city":130,"state":212,"zip":213,"country":132,"countryCode":133,"cosmosGeoPoint":214,"geoPoint":216,"contacts":217},"Fondazione Policlinico Universitario Campus Bio-Medico di Roma, UOC di Medicina Fisica e Riabilitativa-CESA","RM","00128",{"type":59,"coordinates":215},[136,137],{"lat":137,"lon":136},[218,221],{"name":219,"role":40,"phone":67,"phoneExt":67,"email":220},"Federica Bressi, MD, PhD","f.bressi@policlinicocampus.it",{"name":219,"role":37,"phone":67,"phoneExt":67,"email":67},{"facility":5,"status":223,"city":130,"state":212,"zip":224,"country":132,"countryCode":133,"cosmosGeoPoint":225,"geoPoint":227,"contacts":228},"RECRUITING","00163",{"type":59,"coordinates":226},[136,137],{"lat":137,"lon":136},[229,232,233,234],{"name":36,"role":40,"phone":230,"phoneExt":42,"email":231},"0652252405","sanaz.pournajaf@sanraffaele.it",{"name":45,"role":40,"phone":67,"phoneExt":67,"email":48},{"name":36,"role":37,"phone":67,"phoneExt":67,"email":67},{"name":45,"role":235,"phone":67,"phoneExt":67,"email":67},"SUB_INVESTIGATOR",{"facility":237,"status":52,"city":238,"state":67,"zip":239,"country":132,"countryCode":133,"cosmosGeoPoint":240,"geoPoint":244,"contacts":245},"ASST Papa Giovanni XXIII","Bergamo","24127",{"type":59,"coordinates":241},[242,243],9.66721,45.69601,{"lat":243,"lon":242},[246,249],{"name":247,"role":40,"phone":67,"phoneExt":67,"email":248},"Serena Monteleone, MD, PhD","smonteleone@asst-pg23.it",{"name":247,"role":37,"phone":67,"phoneExt":67,"email":67},{"facility":251,"status":52,"city":252,"state":67,"zip":67,"country":132,"countryCode":133,"cosmosGeoPoint":253,"geoPoint":257,"contacts":258},"University of Catanzaro \"Magna Graecia\"","Catanzaro",{"type":59,"coordinates":254},[255,256],16.60086,38.88247,{"lat":256,"lon":255},[259,262],{"name":260,"role":40,"phone":67,"phoneExt":67,"email":261},"Alessandro De Sire, MD, PhD","alessandro.desire@unicz.it",{"name":263,"role":37,"phone":67,"phoneExt":67,"email":67},"Antonio Ammendolia, MD",{"facility":265,"status":266,"city":267,"state":67,"zip":67,"country":132,"countryCode":133,"cosmosGeoPoint":268,"geoPoint":272,"contacts":67},"IRCCS Fondazione Don Gnocchi","ACTIVE_NOT_RECRUITING","Florence",{"type":59,"coordinates":269},[270,271],11.24626,43.77925,{"lat":271,"lon":270},{"facility":274,"status":52,"city":275,"state":67,"zip":276,"country":132,"countryCode":133,"cosmosGeoPoint":277,"geoPoint":281,"contacts":282},"Riuniti Hospital, Neurorehabilitation, Spinal Cord Rehab. and Functional Recovery Section","Foggia","7100",{"type":59,"coordinates":278},[279,280],15.55188,41.45845,{"lat":280,"lon":279},[283,286,288],{"name":284,"role":40,"phone":67,"phoneExt":67,"email":285},"Stefania Spina, MD, PhD","spinastefania.ss@gmail.com",{"name":287,"role":40,"phone":67,"phoneExt":67,"email":67},"Salvatore Facciorusso, MD, PhD",{"name":289,"role":37,"phone":67,"phoneExt":67,"email":67},"Andrea Santamato, MD, PhD",{"facility":291,"status":52,"city":292,"state":67,"zip":293,"country":132,"countryCode":133,"cosmosGeoPoint":294,"geoPoint":298,"contacts":299},"IRCCS Centro Neurolesi Bonino-Pulejo, Innovation Technology Laboratory","Messina","98123",{"type":59,"coordinates":295},[296,297],15.55256,38.19394,{"lat":297,"lon":296},[300,303,306],{"name":301,"role":40,"phone":67,"phoneExt":67,"email":302},"Rocco Salvatore Calabrò, MD, PhD","roccos.calabro@irccsme.it",{"name":304,"role":40,"phone":67,"phoneExt":67,"email":305},"Maria Grazia Maggio, PsyD","mariagrazia.maggio@irccsme.it",{"name":301,"role":37,"phone":67,"phoneExt":67,"email":67},{"facility":308,"status":52,"city":309,"state":67,"zip":310,"country":311,"countryCode":312,"cosmosGeoPoint":313,"geoPoint":317,"contacts":318},"Medical Centre for Rehabilitation Treatment \"Consilium\"","Moscow","141052","Russia","RU",{"type":59,"coordinates":314},[315,316],37.61781,55.75204,{"lat":316,"lon":315},[319,322],{"name":320,"role":40,"phone":67,"phoneExt":67,"email":321},"Vyacheslav Anatolievich Filimonov, MD, PhD","mcvlconsilium@mail.ru",{"name":320,"role":37,"phone":67,"phoneExt":67,"email":67},{"facility":324,"status":52,"city":325,"state":67,"zip":326,"country":327,"countryCode":328,"cosmosGeoPoint":329,"geoPoint":333,"contacts":334},"Centro Lescer, Occupational Therapy and Physical Therapy Department","Madrid","28050","Spain","ES",{"type":59,"coordinates":330},[331,332],-3.70256,40.4165,{"lat":332,"lon":331},[335,338,339],{"name":336,"role":40,"phone":67,"phoneExt":67,"email":337},"Estefania Morcillo de Mercado, OT","emorcillo@lescer.es",{"name":336,"role":37,"phone":67,"phoneExt":67,"email":67},{"name":340,"role":37,"phone":67,"phoneExt":67,"email":67},"Daniel Arturo Catillo, PT",{"facility":342,"status":52,"city":343,"state":67,"zip":344,"country":345,"countryCode":346,"cosmosGeoPoint":347,"geoPoint":351,"contacts":352},"Chiang Mai University, Department of Occupational Therapy, Faculty of Associated Medical Sciences","Chiang Mai","50200","Thailand","TH",{"type":59,"coordinates":348},[349,350],98.98468,18.79038,{"lat":350,"lon":349},[353,357,359],{"name":354,"role":40,"phone":355,"phoneExt":67,"email":356},"Sopida Apichai, OT, PhD","Jananya","sopida.apichai@cmu.ac.th",{"name":358,"role":40,"phone":67,"phoneExt":67,"email":67},"Dhippa, OT, PhD",{"name":354,"role":37,"phone":67,"phoneExt":67,"email":67},{"type":361,"investigatorFullName":67,"investigatorTitle":67,"investigatorAffiliation":67,"oldNameTitle":67,"oldOrganization":67},"SPONSOR","100580606","robotic-rehabilitation-of-the-upper-limb-in-subacute-stroke-100580606",false,"NCT06839482","Robotic Rehabilitation of the Upper Limb in Subacute Stroke","Efficacy of Robotic Rehabilitation for Neuro Recovery of the Upper Limb in Subacute Stroke Survivors: An International Multicenter Randomized Controlled Trial","GLORIA","Inclusion Criteria:\n\n* Both sexes\n* Age 18-90 years\n* Paresis of the upper limb following a recent cerebrovascular event (subacute ischemic or hemorrhagic stroke)\n* Moderate to mild muscle weakness in the thumb opponens, common finger flexors, and wrist flexors, assessed with complete joint movement in absence of gravity, Medical Research Council Scale (MRC) ≥ 2\n* Time from acute event \\\u003C90 days\n* Ability to understand and sign the study informed consent\n* Ability to perform study procedures.\n\nExclusion Criteria:\n\n* Presence of other overlapping neurological disorders\n* Presence of osteoarticular or neuromuscular disorders affecting upper limb mobility\n* Severe psychiatric disorders\n* Severe cognitive (MMSE ≤ 17) and\u002For language impairment compromising exercise comprehension\n* Botulinum toxin injection in the affected upper limb within the last 60 days or planned during the study and follow-up period\n* Open wounds, infections, or unprotected skin lesions on the upper limb\n* Severe spasticity of the upper limb (biceps and wrist and finger flexors) (MAS \\> 3)\n* Inability to adhere to the exercise program due to low compliance\n* Participants who have not signed the informed consent for the study","ALL","18 Years","85 Years",{"count":374,"type":375},130,"ESTIMATED","INTERVENTIONAL",[378],"NA","This multicenter international randomized controlled trial (RCT) evaluates the effectiveness of the Gloreha Sinfonia® robotic exoskeleton for upper limb rehabilitation in individuals with subacute post-stroke paresis. The study aims to determine whether robotic-assisted therapy improves voluntary motor control and coordination more effectively than conventional rehabilitation, as measured by the Fugl-Meyer Assessment (FMA) for the upper limb (motor component).\n\nParticipants will be randomly assigned to one of two groups:\n\n* Experimental Group (EG): Robotic-assisted upper limb rehabilitation combined with conventional therapy.\n* Control Group (CG): Conventional therapy alone including upper limb rehabilitation.\n\nClinical assessments will be conducted at baseline (T1), post-treatment (T2), and at a 3-month follow-up (T3) using remotely administered scales.\n\nSecondary objectives include evaluating improvements in muscle strength, range of motion, eye-hand coordination, manual dexterity, and functional independence. The study will also assess prognostic factors influencing response to robotic therapy, patient satisfaction, and potential adverse events.",[381],"Stroke",[381,383,384,385,386,387,388,389],"Upper Limb","Hand","Rehabilitation","Robotic- Assisted Therapy","Subacute phase","Activities of Daily Living (ADL)","Quality of Life","2026-04-20",{"date":392,"type":393},"2026-04-23","ACTUAL",{"date":395,"type":393},"2025-02-06",{"date":397,"type":375},"2028-01-31",{"name":5,"class":6},21]