[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100517976":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":19,"locations":27,"responsibleParty":42,"collaborators":10,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":10,"enrollmentInfo":53,"targetDuration":10,"studyType":56,"phases":10,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":68,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"University Hospital, Bordeaux","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"Prospective part of the study",null,[12],"Procedure: Tumor samples",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"PROCEDURE","Tumor samples","Tumor samples will be collected by the pathologist at the reception of the tumor removed during surgery",[9],[20,24],{"name":21,"role":22,"phone":10,"phoneExt":10,"email":23},"Charlotte DOMBLIDES","CONTACT","charlotte.domblides@chu-bordeaux.fr",{"name":25,"role":22,"phone":10,"phoneExt":10,"email":26},"Matthieu THUMEREL","matthieu.thumerel@chu-bordeaux.fr",[28],{"facility":29,"status":10,"city":30,"state":10,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"CHU de Bordeaux - Hôpital Saint-André, Service d'Oncologie Médicale","Bordeaux","33000","France","FR",{"type":35,"coordinates":36},"Point",[37,38],-0.58046,44.84124,{"lat":38,"lon":37},[41],{"name":21,"role":22,"phone":10,"phoneExt":10,"email":23},{"type":43,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100517976","role-of-cancer-associated-fibroblast-mdscs-and-immune-cell-interplays-in-the-resistance-of-non-small-cell-lung-cancer-to-anti-pd1pd-l1-therapies-100517976",false,"NCT06024538","Role of Cancer-associated Fibroblast, MDSCs and Immune Cell Interplays in the Resistance of Non-small Cell Lung Cancer to Anti-PD1\u002FPD-L1 Therapies","COCKPI-T","Inclusion Criteria:\n\n* consecutive patients\n* lung carcinoma surgically treated by surgery only (objectives 1a and 2), or stage III lung carcinoma treated by concomitant radiochemotherapy followed by durvalumab (maintenance) treated between September 2018 and december 2021 (objective 1b)\n\nExclusion Criteria:\n\n* patient receiving chemotherapy, radiotherapy or immunotherapy in the neoadjuvant setting (all objectives)\n* patient with previous cancer","ALL","18 Years",{"count":54,"type":55},25,"ESTIMATED","OBSERVATIONAL","Immunotherapy have revolutionized the field of oncology, but response rates are low and all patients relapse, due to cellular and soluble immunosuppressive mechanisms. These immunosuppressive mechanisms will be better characterized and their involvement in therapeutic responses in non-small cell lung cancers (NSCLC). Indeed, large transcriptomic analysis of different subsets of immunosuppressive cells will performed, correlating them to clinical outcome in a cohort of stage III disease, treated by radiochemotherapy and immunotherapy as maintenance, and stage IV treated by immunotherapy as first-line treatment. Furthermore, we will analyse cellular mechanisms by in vitro studies, assessing the effect of immunosuppressive cells, provided by fresh tumor samples, on phenotype and functions of lung cancer cell lines. The aim of this study is to better characterize immunosuppressive landscape of NSCLC and mechanisms involved in their protumor functions.",[59,60,61],"Lung Neoplasm","Cancer Associated Fibroblast","Myeloid-Derived Suppressive Cells Immunosuppression",[63,64,65,66,67],"Lung cancer","Immunosuppression","Immunotherapy","Immuno-oncology","Antitumor immune escape","NOT_YET_RECRUITING","2025-07-29",{"date":71,"type":72},"2025-07-30","ACTUAL",{"date":74,"type":55},"2025-12",{"date":76,"type":55},"2026-12",{"name":5,"class":6},1]