[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619608":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":32,"locations":39,"responsibleParty":59,"collaborators":10,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":10,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":10,"studyType":75,"phases":10,"briefSummary":76,"conditions":77,"keywords":10,"overallStatus":42,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Benha University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"T. gondii Seropositive Group",null,"Women with diagnosed psychiatric disorders (Schizophrenia, MDD, or Bipolar Disorder) who test positive for anti-Toxoplasma IgG antibodies, indicating chronic infection.",[13],"Diagnostic Test: Circulating miRNA Expression and T. gondii Serology",{"label":15,"type":10,"description":16,"interventionNames":17},"T. gondii Seronegative Group","Women with the same diagnosed psychiatric disorders who test negative for anti-Toxoplasma IgG antibodies",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","Circulating miRNA Expression and T. gondii Serology","Serology: ELISA testing to detect anti-Toxoplasma IgG (confirming chronic infection) and IgM (excluding acute infection).\n\nGenetic Analysis: Quantitative Reverse-transcriptase PCR (qRT-PCR) to measure the expression levels of a predetermined panel of plasma miRNAs.\n\nPsychiatric Evaluation: Clinical diagnosis according to DSM-5 criteria.",[15,9],[25,29],{"name":26,"affiliation":27,"role":28},"Basma Salem, MD","Assistant Professor Clinical and Chemical Pathology. Faculty of Medicine, Benha University, Egypt","PRINCIPAL_INVESTIGATOR",{"name":30,"affiliation":31,"role":28},"Dina Abd El hadi, MD","Assistant Professor Medical Parasitology. Faculty of Medicine, Benha University, Egypt",[33],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},"Heba Abo El Ela, MD","CONTACT","01062702236","+2","b.checked88@gmail.com",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Benha faculty of Medicine","RECRUITING","Banhā","El Qalyoubia","13511","Egypt","EG",{"type":49,"coordinates":50},"Point",[51,52],31.1842,30.45977,{"lat":52,"lon":51},[55],{"name":56,"role":35,"phone":57,"phoneExt":58,"email":38},"Hesham Rashid, Professor","101 497 7666","+20",{"type":28,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Heba M. Aboelela","Assistant Professor of Medical Parasitology, Faculty of Medicine, Benha University, Egypt","100619608","role-of-circulating-micrornas-in-differentiating-psychological-disorders-among-women-with-chronic-toxoplasmosis-100619608",false,"NCT07346833","Role of Circulating MicroRNAs in Differentiating Psychological Disorders Among Women With Chronic Toxoplasmosis","Deciphering The Role of Circulating MicroRNAs To Differentiate Psychological Disorders Among Women With Chronic Toxoplasmosis","Inclusion Criteria:\n\n* Confirmed psychiatric diagnosis of Schizophrenia (SCZ), Major Depressive Disorder (MDD), or Bipolar Disorder (BD) according to DSM-5 criteria.\n* Seronegative for T. gondii IgM (to ensure infection is not in the acute phase).\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Psychiatric disorders other than Schizophrenia, MDD, and Bipolar Disorder.\n\nSeropositive for T. gondii IgM (indicating acute infection).\n\nRefusal to participate.","FEMALE","18 Years","50 Years",{"count":73,"type":74},55,"ESTIMATED","OBSERVATIONAL","Chronic Toxoplasma gondii (T. gondii) infection is a widespread condition that can negatively affect brain function and is considered a risk factor for various psychiatric conditions, including depression and schizophrenia. This prospective observational study aims to investigate the expression levels of specific circulating microRNAs (miRNAs) in women diagnosed with schizophrenia, major depressive disorder, or bipolar disorder who also have chronic toxoplasmosis. By comparing these levels to patients without the infection, the study seeks to determine if these miRNAs can serve as biological markers to help differentiate between specific psychological disorders and identify the impact of chronic toxoplasmosis on mental health.",[78],"Toxoplasmosis","2026-01-08",{"date":81,"type":82},"2026-01-16","ACTUAL",{"date":84,"type":82},"2025-11-20",{"date":86,"type":74},"2026-04",{"name":5,"class":6},1]